Background and Purpose—Preclinical research using animals often informs clinical trials. However, its …
Background and Purpose—Preclinical research using animals often informs clinical trials. However, its value is dependent on its scientific validity and reproducibility, which are, in turn, dependent on rigorous study design and reporting. In 2011, Stroke introduced a Basic Science Checklist to enhance the reporting and methodology of its preclinical studies. Except for Nature and Science journals, few others have implemented similar initiatives. We sought to estimate the impact of these journal interventions on the quality of their published reports.Methods—All articles published in Stroke, Nature Medicine, and Science Translational Medicine over 9 to 18 years and in 2 control journals without analogous interventions over a corresponding 11.5 years were reviewed to identify reports of experiments in nonhuman mammals with proposed clinical relevance. The effect of journal interventions on the reporting and use of key study design elements was estimated via interrupted time-series analyses.Results—Of 33 009 articles screened, 4162 studies met inclusion criteria. In the 3.5 to 12 years preceding each journal’s intervention, the proportions of studies reporting and using key study design elements were stable except for blinding in Stroke and randomization in Science Translational Medicine, which were both increasing. Post-intervention, abrupt and often marked increases were seen in the reporting of randomization status (level change: +17% to +44%, P≤0.005), blinding (level change: +20% to +40%, P≤0.008), and sample size estimation (level change: 0% to +40%, P≤0.002 in 2 journals). Significant but more modest improvements in the use of these study design elements were also observed. These improvements were not seen in control journals.Conclusions—Journal interventions such as Stroke’s author submission checklist can meaningfully improve the quality of published preclinical research and should be considered to enhance study transparency and design. However, such interventions are alone insufficient to fully address widespread shortcomings in preclinical research practices.
183FAM256 Keeping Up with New Mandates Course Materials Summary: This site contains …
183FAM256 Keeping Up with New Mandates Course Materials Summary: This site contains the materials for the Keeping Up with New Mandates course. There are materials that we are asking the participants to copy and bring with them to the class. There are materials that the Resource Center will provide for participants and there are materials that we are providing to participants that we ask for them to review prior to the class that do not need to be printed.
A unique perspective on the confluence of the three basic conceptual frameworks …
A unique perspective on the confluence of the three basic conceptual frameworks in human experience. Contains several studies, with data, of remarkable world views of disparate cultures based on their specific cultures language. The premise is that how people experience the world, then think about it, then create a language around it, alters their perception of the world in very fundamental ways. The radical notion is that thought and language, creates the circumstances of, and contribute to significantly different realities for different peoples.
The internalization and realization of this concept is significant and can possibly radically alter and change how different cultures assess their ability to, at the most basic levels, understand other cultures realities.
Library Carpentry lesson: An introduction to Git. What We Will Try to …
Library Carpentry lesson: An introduction to Git. What We Will Try to Do Begin to understand and use Git/GitHub. You will not be an expert by the end of the class. You will probably not even feel very comfortable using Git. This is okay. We want to make a start but, as with any skill, using Git takes practice. Be Excellent to Each Other If you spot someone in the class who is struggling with something and you think you know how to help, please give them a hand. Try not to do the task for them: instead explain the steps they need to take and what these steps will achieve. Be Patient With The Instructor and Yourself This is a big group, with different levels of knowledge, different computer systems. This isn’t your instructor’s full-time job (though if someone wants to pay them to play with computers all day they’d probably accept). They will do their best to make this session useful. This is your session. If you feel we are going too fast, then please put up a pink sticky. We can decide as a group what to cover.
Library Carpentry lesson to learn how to use the Shell. This Library …
Library Carpentry lesson to learn how to use the Shell. This Library Carpentry lesson introduces librarians to the Unix Shell. At the conclusion of the lesson you will: understand the basics of the Unix shell; understand why and how to use the command line; use shell commands to work with directories and files; use shell commands to find and manipulate data.
This is an introductory text intended for a one-year introductory course of …
This is an introductory text intended for a one-year introductory course of the type typically taken by biology majors, or for AP Physics 1 and 2. Algebra and trig are used, and there are optional calculus-based sections. My text for physical science and engineering majors is Simple Nature.
This is a textbook meant for use within The Living Arts (FINE …
This is a textbook meant for use within The Living Arts (FINE 101) -- Chapters include introductions to Painting, Sculpture, Architecture, Theatre, Music, and Dance.
Course Description: An interdisciplinary survey of human creative efforts as they relate to each other. The visual and performing arts are compared with similarities stressed.
"Future Ready: Financial Literacy" is an educational resource that focuses on teaching …
"Future Ready: Financial Literacy" is an educational resource that focuses on teaching essential money management skills. Participants will learn about budgets, financial risks, and strategies to effectively manage their finances. The course covers important concepts such as budgeting, net worth, financial goals, insurance, and saving and investing. By following the provided guidelines and tips, learners will develop a solid understanding of how to manage money in a healthy and responsible way, paving the path towards a financially secure future.
This module contains a series of demonstration videos on how to do …
This module contains a series of demonstration videos on how to do isolated smooth muscle preparation in vitro using the Harvard Kymograph simulator. This series is complementary to the video Setting Up the Harvard Kymograph.This module has been internally reviewed by a cross-disciplinary committee within KNUST prior to releasing as an Open Educational Resource.
This course covers basic topics in autonomous marine vehicles, focusing mainly on …
This course covers basic topics in autonomous marine vehicles, focusing mainly on software and algorithms for autonomous decision making (autonomy) by underwater vehicles operating in the ocean environments, autonomously adapting to the environment for improved sensing performance. It will introduce students to underwater acoustic communication environment, as well as the various options for undersea navigation, both crucial to the operation of collaborative undersea networks for environmental sensing. Sensors for acoustic, biological and chemical sensing by underwater vehicles and their integration with the autonomy system for environmentally adaptive undersea mapping and observation will be covered. The subject will have a significant lab component, involving the use of the MOOS-IvP autonomy software infrastructure for developing integrated sensing, modeling and control solutions for a variety of ocean observation problems, using simulation environments and a field testbed with small autonomous surface craft and underwater vehicles operated on the Charles River.
The structure of the course is designed to have students acquire a …
The structure of the course is designed to have students acquire a broad understanding of the field of Marine Chemistry; to get a feel for experimental methodologies, the results that they have generated and the theoretical insights they have yielded to date.
Students are introduced to classroom routines and expectations, and complete a full …
Students are introduced to classroom routines and expectations, and complete a full mathematics lesson. The class discusses how to clearly present work to classmates. Partner work is modeled, and partners then work to match numerical expressions to corresponding word descriptions. Students read and discuss a summary of the math in the lesson, and then write a reflection about their thoughts.Key ConceptsStudents match a numerical expression to its corresponding description in words. Students interpret parentheses and brackets in numerical expressions and they construct viable arguments and critique the reasoning of others. Students learn to use the exponent 2 to represent squaring.Goals and Learning ObjectivesDescribe the classroom routines and expectations.Consider how to present work clearly to classmates.Collaborate with a partner.Critique a partner’s reasoning.Connect a numerical expression to its corresponding word description.Learn to use an exponent of 2 to represent squaring.
This is a calculus-based book meant for the first semester of the …
This is a calculus-based book meant for the first semester of the type of freshman survey course taken by engineering and physical science majors. A treatment of relativity is interspersed with the Newtonian mechanics, in optional sections. The book is designed so that it can be used as a drop-in replacement for the corresponding part of Simple Nature, for instructors who prefer a traditional order of topics. Simple Nature does energy before force, while Mechanics does force before energy. Simple Nature has its treatment of relativity all in a single chapter, rather than in parallel with the development of Newtonian mechanics.
Students observe and discuss a cup and pencil model of a cyclone …
Students observe and discuss a cup and pencil model of a cyclone to better understand the science behind how this pollutant recovery method functions in cleaning industrial air pollution.
This type of physics course can easily seem to the student like …
This type of physics course can easily seem to the student like a random grab-bag of topics, consisting of everything that didn’t fit in the earlier semesters on mechanics and electromagnetism. But there is a clear organizing principle for most of what we’ll be studying. It has to do with two surprising facts about time. In particular, one of these facts leads us to the conclusion that light and matter can’t really be made of particles, as envisioned by Isaac Newton’s grand vision of the universe — they must be made of waves.
Short Description: In the face of so many unprecedented changes occurring in …
Short Description: In the face of so many unprecedented changes occurring in our lives, our ecosystems and our globe, society is more often expecting scientists to provide information that can help guide communities toward a more sustainable future. This book is our attempt to provide a framework that managers of natural resources can use to design monitoring programs that will benefit future generations by providing the information needed to make informed decisions. In addition we offer tools and approaches that engage individuals in our society in monitoring programs. We firmly believe that people and communities who are empowered in the design and implementation of monitoring programs are more likely to use the information that results from the program, and support it over time. Data dashboard
Word Count: 106934
(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)
Student groups are challenged to design and construct model towers out of …
Student groups are challenged to design and construct model towers out of newspaper. They are given limited supplies including newspaper, tape and scissors, paralleling the real-world limitations faced by engineers, such as economic restrictions as to how much material can be used in a structure. Students aim to build their towers for height and stability, as well as the strength to withstand a simulated lateral "wind" load.
Through this unit, students act as engineers who are given the challenge …
Through this unit, students act as engineers who are given the challenge to design laparoscopic surgical tools. After learning about human anatomy and physiology of the abdominopelvic cavity, especially as it applies to laparoscopic surgery, students learn about the mechanics of elastic solids, which is the most basic level of material behavior. Then, they explore the world of fluids and learn how fluids react to forces. Next, they combine their understanding of the mechanics of solids and fluids to understand viscoelastic materials, such as those found in the human body. Finally, they learn about tissue mechanics, including how collagen, elastin and proteoglycans give body tissues their unique characteristics. In the culminating hands-on activity, student teams design their own prototypes of laparoscopic surgical robots remotely controlled, camera-toting devices that must fit through small incisions, inspect organs and tissue for disease, obtain biopsies, and monitor via ongoing wireless image-taking. They use a (homemade) synthetic abdominal cavity simulator to test and iterate the prototype devices.
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