This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The development of long-read sequencing has allowed for the generation of more complete and contiguous genomes in metagenomics studies. However, long-reads are more prone to sequencing errors than short-reads, and these errors can end up incorporated in the draft genomes. Combining short- and long-reads can overcome such errors, but is computationally taxing. To avoid this, researchers developed the ‘Hierarchical Clustering Based Hybrid Assembly (HCBHA) approach.’ This approach first groups the long- and short-reads into candidate bacterial haplotypes and then assembles each group separately, which reduces the computational demand . Researchers tested this framework on a microbiome from activated sludge, an important part of wastewater treatment. The highly complex microbiomes found in activated sludge remove pollutants from wastewater..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Instructions on how to extract DNA from students cheek cells. Includes follow-up questions.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Bacteria and viruses are locked in a perpetual arms race. As bacterial viruses continuously try to penetrate and infect bacteria, bacteria are endlessly evolving anti-viral defense systems. Understanding how this struggle unfolds is critical, as bacteria are a vital component of many emerging biotechnologies and foods we eat. Scientists recently explored the battles that take place in cheese, where the presence of only a few species of bacteria makes an ideal, simple, and reproducible model system. The communities they analyzed harbored highly diverse defense mechanisms, even among nearly identical strains, suggesting rapid evolution. Additionally, the abundances of CRISPR spacers and their phage targets were correlated, suggesting that bacteria have genetic mechanisms for effectively defending against viral foes..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Short Description:
Proteins play vital roles in most biological processes; these roles include acting as catalysts for physiological reactions, as regulators for those reactions, or as structural framework around which these processes can occur. Proteins’ complex organization of diverse functionality in 3D space leads to an astonishing range of function for living organisms. Understanding this intimate relationship between structure and function is the backbone of understanding the natural world and is the key to controlling it. Data dashboard

Word Count: 13793

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Brain development can be damaged by environmental chemicals.
Philippe Grandjean, University of Southern Denmark and Harvard School of Public Health, explains the erroneous assumptions made over time about this. Studies from Faroe Islands, where people have been exposed to toxic agents, shows how this affects brains of children and their IQ levels.

This kit is a historical overview of American representations of chemicals from the three sisters to the Love Canal. It compares conflicting constructions about nuclear reactor safety, depleted uranium, Rachel Carson and DDT. Through analyzing diverse historic and contemporary media messages, students understand changing public knowledge, impressions and attitudes about chemicals in the environment.

This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making. Throughout the term, students consider case studies of local and national interest.

Une anthologie de L’Entraide missionnaire

Short Description:
CETTE ANTHOLOGIE PRESENTE 60 TEXTES CLASSES CHRONOLOGIQUEMENT REFLETANT DES PREOCCUPATIONS SOCIALES, POLITIQUES ET SPIRITUELLES EN EVOLUTION. CES TEXTES SONT MAJORITAIREMENT DES CONFERENCES QUI ONT ETE PRONONCEES LORS DU CONGRES ANNUEL DE L’ENTRAIDE MISSIONNAIRE JUSQU'EN 2015, OFFRANT UN ECHANTILLON DES TRESORS QUI SE TROUVENT DANS SES ARCHIVES.

Long Description:
Incorporé en 1958, L’Entraide missionnaire a réalisé un parcours remarquable au service de la solidarité internationale grâce à l’engagement soutenu de ses membres, des personnes responsables de la permanence et un grand nombre de collaboratrices et collaborateurs à travers le monde. En 2015, suite à une lecture collective des signes des temps, les membres de L’Entraide missionnaire ont pris la décision d’entamer un processus de transmission d’héritage avant de fermer l’organisme au printemps 2018.

En offrant un échantillon, certes très limité, des trésors qui se trouvent dans les archives de L’Entraide missionnaire, cette anthologie présente 60 textes classés chronologiquement reflétant des préoccupations sociales, politiques et spirituelles en évolution. L’essentiel de ces textes sont des conférences qui ont été prononcées lors du Congrès annuel de l’Entraide missionnaire, véritable lieu de rassemblement, d’échanges, de réflexions et de critiques sociales.

À la lumière de l’introduction et à travers les lectures sélectionnées, on découvre, même dans les textes écrits sur du vieux papier, des archives qui sont toujours en conversation avec le présent, attentives aux signes des temps. Nous y découvrons des brèches de résistance et d’affirmation de vie et d’humanité solidaire contre les obstacles qui nous confrontent. Nous y trouvons une continuité jusqu’au dernier geste de transmission du legs : un engagement profond et réfléchi qui exige de l’audace, de l’indignation face à l’injustice et de l’espérance pour la transformation du monde.

Word Count: 265162

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

In this syllabus from Fall 2022, Dr. Breeyawn Lybbert provides an outline of the semester using a revised open text from Saylor Academy.

Lesson 1: Intro to Chemistry, Matter, Numbers, & Calculations; Lesson 2: Elements, Atoms, & the Periodic Table; Lesson 3: Ionic & Covalent bonds and compounds; Lesson 4: Chemical Equations & Calculations (firsthalf - 4A); Lesson 4: Chemical Equations & Calculations (second half - 4B); Lesson 5: Intermolecular Forces,Solutions, Energy & Equilibrium; Lesson 6: Acid-Base Chemistry; Lesson 7: Introduction to Organic Chemistry (first part - A); Lesson 7: Introduction to Organic Chemistry (first part - B); Lesson 8: Carbohydrates & Lipids; Lesson 9: Amino Acids, Proteins, & Enzymes; Lesson 10: Nucleic Acids, DNA/RNA; Lesson 10: Nucleic Acids, DNA/RNA; Lesson 11: Metabolism (Part A)- Metabolism Intro, Glycolysis, Krebs Cycle; Lesson 11: Metabolism (Part B)
- Electron Transport Chain, Urea Cycle, B-oxidation

A presentation with Professor Philippe Grandjean about the dangers of chemical interference with the developing brain. This presentation, “Children’s health - Risks to brain development from exposure to environmental chemicals”, presented on 6th November, 2019, meeting of the French High Council for Public Health (Haut Conseil de la Santé Publique, HCSP), at the Ministry for Solidarity and Health in Paris.

This week we're headed to China to learn about the ancient origins of theater there. We'll look at the early days of wizard theater (not a typo), the development of classical Chinese theater, and the evolution of Beijing Opera.

China’s rise as a great power raises important questions about how that power might be used in its relations with other states. Nowhere are such questions more salient than in the future trajectory of China’s conflict behavior, including its approach to deterrence, crisis management and the use of force. To explore these important questions in China’s international relations, this seminar examines the evolution of Chinese strategic thought, in primary sources as well as its reflection in the interactions among Chinese states and between China and other states.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Most microbial biomass in the ocean is found in the deep sea. Deep-sea microbes are important agents for organic matter (OM) recycling and storage, but it’s unclear how these organisms cope with the fluctuating OM supply in the deep ocean, especially in the deepest areas: the hadal trenches. To learn more, a new study examined the metabolic potential of microbes in the phylum Chloroflexi using sediment samples from the Mariana Trench. Metagenomic sequencing revealed 6 novel species, 4 novel genera, 1 novel family, and 1 novel order of Chloroflexi in the sediment. Based on the sequences, the associated microbes were primarily OM consumers that could degrade various organic carbon (OC), sulfur, and halogenated compounds and could even metabolize degradation-resistant types of OM, such as polyaromatic hydrocarbons (PAHs)..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is intended for an introductory or intermediate-level college genetics course. It begins with an exploration of DNA and genome structure and continues with a study of the molecular mechanisms that drive gene expression. Concepts of classical transmission genetics are linked to the molecular mechanisms that underlie observable phenotypes. It concludes with specific topics that synthesize information from both molecular and transmission genetics, including consideration of topics like epigenetics, cancer biology, and evolution. Examples of both historical and current problems in genetics are presented, along with conversations of the relationship between genetics and society.

LEARNING OUTCOMESDifferentiate between two kinds of chromosomes: autosomes and sex chromosomesUnderstand how DNA is protected and compacted inside cells

Overview of DNA transcription, translation, and replication during mitosis and meiosis. Learn about chromosomes, chromatids, and chromatin.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Osteoarthritis is the most common form of joint disease, affecting hundreds of millions of people worldwide. One promising therapeutic target is TGF-β signaling. Studies have shown that blocking this signaling pathway can slow the progression of osteoarthritis. The problem is that TGF-β signaling is also critical for repairing the cartilage cells that are degraded in osteoarthritis. To help separate the bad from the good, researchers recently examined the genetic blueprints that control TGF-β signaling. They discovered a key player in circPhf21a, a type of rare genetic material known as circular RNA. Initially believed to be misshapen RNA, circular RNA is being revealed as an important mediator of disease. In the current study, the team found that overexpression of circPhf21a led to the growth of fewer-than-normal cartilage cells in mice. And in mice with osteoarthritis, levels of circPhf21a were found to be significantly increased..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

lab assignments intended to teach the basics of reading phylogenetic diagrams and parsimony optimization.

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The topic of this video module is how to classify animals based on how closely related they are. The main learning objective is that students will learn how to make phylogenetic trees based on both physical characteristics and on DNA sequence. Students will also learn why the objective and quantitative nature of DNA sequencing is preferable when it come to classifying animals based on how closely related they are. Knowledge prerequisites to this lesson include that students have some understanding of what DNA is and that they have a familiarity with the base-pairing rules and with writing a DNA sequence.

If you'd visited Tuolumne Meadows in Yosemite National Park 100 years ago, you probably would have encountered the alpine chipmunk, Tamias alpinus. Today, however, park visitors will have to hike up a nearby mountain to see one of these critters. That's because this species is sensitive to temperature and over the last hundred years of global climate change, Yosemite has warmed by about 5.5 degrees Fahrenheit. As the temperature increased, the chipmunks retreated to higher and higher elevations where it was cooler. Today, they occupy a fraction of their original range. If climate change continues, they could be squeezed right off the tops of their mountains and out of existence.