This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Healthy corneas are clear and lack blood vessels, but injuries like alkali burns can trigger neovascularization. This serious complication reduces the patient’s vision and is the leading cause of failure in corneal transplants. Previous studies have suggested that AIP1 (Apoptosis signal-regulating kinase 1-interacting protein) is involved in inflammatory neovascularization induction and that NOX4 (NADPH oxidase 4) is activated by alkali burns. NOX4 can produce reactive oxygen species (ROS) which unbalance the expression of the inflammation-related proteins NLRP3 and NLRP6 (NLR family pyrin domain containing 3 and 6). Researchers recently used a mouse model to examine how AIP1 and NOX4 are related to NLRP3/NLRP6 after corneal alkali burns. Corneal alkali burns decreased AIP1 expression and increased the expression of two pro-angiogenic proteins, clv-IL-1β (cleaved interleukin-1β) and VEGFa (vascular endothelial growth factor A)..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
aiEDU's AI Toolkits are materials designed to support teachers, parents and other community …
aiEDU's AI Toolkits are materials designed to support teachers, parents and other community champions to share the importance of artificial intelligence education and support its adoption in your learning spaces.
This resource includes traditional writing prompts as well as prompts and assignments …
This resource includes traditional writing prompts as well as prompts and assignments that utilize AI-generated text. It covers the fields of Creative Writing, Composition, and Business and Technical Writing.
World Education's AI for Learning and Work initiative is dedicated to exploring the intersection …
World Education's AI for Learning and Work initiative is dedicated to exploring the intersection of artificial intelligence and education, and how it can shape the future of the way we live and work. On this page, you can access open resources, professional development offerings and opportunities to get involved.
AI and education are not just topics for industry. The education system …
AI and education are not just topics for industry. The education system should be prepared to identify how best to make use of AI in the classroom, reassure teachers, make them responsible users and start an effective teacher-training program. The goal of this textbook is to give teachers the knowledge necessary for deciding if, where and how AI can help. • How can artificial intelligence impact learning and teaching in my classroom? • Can it help me do what I want to do with my students? • How can it change the dynamics and interactions I have with my students? • How do I even know when it is being used correctly or incorrectly? • And, what should I be aware of if I want to put it to good use? Available in English, French, German, Italian, and Slovenian
Garnet Valley School District in PA established a deep commitment to open …
Garnet Valley School District in PA established a deep commitment to open education when it first joined the #GoOpen Network over eight years ago to advance an OER initiative. Still on an innovative journey to transform teaching and learning, the district’s Director of Technology and Online Learning and Founder and Executive Director of nonprofit Edvative Learning, Sam Mormando is actively exploring the rapidly evolving landscape of AI technology and reflecting on ways it may be advantageous for education, and specifically, for OER.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Some proteins are central to many cell signaling processes. One of these key molecules is AKT2. An important kinase involved in cell survival, growth, and metabolism, it has ties to insulin-induced signaling and cancer. AKT2 has a critical role in immune cells such as neutrophils and macrophages; however, although AKT2 is expressed in antibody-producing immune cells called B cells, its function in B cells isn’t clear. In a recent study, researchers sought to understand the role of AKT2 in B cells using AKT2-deficient mice. They found that mice lacking AKT2 had impaired B-cell differentiation. B cells from these mice were not able to form a cluster of molecules called a signalosome in response to B-cell receptor (BCR) signaling, resulting in poor BCR signaling and impaired B cell activation and spreading. These results suggest that as a central orchestrator of signaling, AKT2 function is critical for proper BCR signaling and B cell development, ensuring a functional antibody-mediated immune response..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Gq protein-coupled receptors (GqPCRs) are membrane bound proteins that transmit signals from outside the cell to internal signaling pathways. One of these pathways is the PI3K/AKT pathway, which plays roles in cellular proliferation, survival, metabolism, and differentiation. PI3K/AKT dysregulation is also often implicated in cancers. A previous study determined that activating GqPCRs in certain cells inactivated AKT, which led to a specific type of cell death, JNK-dependent apoptosis. This unique signal seems to play an important role in physiological and pathological events like pituitary development and cardiac hypertrophy. Now, a new study determined that the mechanism of this AKT inactivation relies on another signaling-related protein, PP2A. When the GqPCRs are not activated, a fraction of PP2A "c" subunit is in a dimer complex with another protein, IGBP1 and they are bound to the p85 subunit of PI3K, causing its activation..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
ALAMOSE aims to educate undergraduate and graduate students on (i) what categories …
ALAMOSE aims to educate undergraduate and graduate students on (i) what categories of security weaknesses appear for artifacts used in DevOps, and (ii) how identified security weaknesses can be detected. ALAMOSE is funded by the U.S. National Science Foundation (NSF), and spearheaded by Akond Rahman at Auburn University. Please contact him with questions at akond@auburn.edu.
The standard citation style guide book for the fields of business, education, …
The standard citation style guide book for the fields of business, education, health science, public service, and social science is the Publication Manual of the American Psychological Association, 6th edition, 2010. The American Psychological Association (APA) publishes the manual. We commonly refer to it as "the APA Manual".
The business, education, health science, public service, and social science departments at IRSC recommend APA format for papers written in these fields.
Two types of citations are included in most research papers: citations within the text of the document and a list of reference citations at the end of the paper.
In-Text Citations:
The APA Manual uses the author-date citation system for in-text citations.
Reference Citations:
The sources you use in your work are included as a separate list at the end of the paper. The APA Manual suggests using the title, References, for the list.
This textbook introduces students to the application methods of control charts to …
This textbook introduces students to the application methods of control charts to improve quality in health care. The textbook is written to be accessible to any student in the areas of health information management, health care informatics, and health care industrial engineering. Having a basic background in statistics would be beneficial, but such training is not a prerequisite to understanding how to apply the techniques discussed here. Several How-To sections are included to demonstrate the implementation of the given control charts using software such as Minitab and Excel. Additionally, samples of a Python code are included and can directly be accessed in a Jupyter Notebook at https://github.com/JeromeNN/Applications-Control-Charts-Quality-Improvement-Health-Care
this document contains usses of polymers in various parts of the automobile …
this document contains usses of polymers in various parts of the automobile and respective examples with the requirement of material to make product and polymers selected with similar properties.
In the last two decades, research in various aspects of mobile ad-hoc …
In the last two decades, research in various aspects of mobile ad-hoc networks, MANETs, has been very active, motivated mainly by military, disaster relief and law enforcement scenarios. More recently, location information has become increasingly available; partially prompted by the emerging trend to incorporate location or position sensing into personal handheld devices. An evolutionary natural step is to adopt such position-based operation in MANETs. This results in what we call position-based MANETs. In such settings, devices are equipped with position-sensing capabilities and rely on position information in their operation. The main distinguishing feature of the envisaged position-based MANET environment is the communication paradigm based not on permanent or semi-permanent identities, addresses or pseudonyms, but on instantaneous node locations or positions. In some application settings, such as: military, law enforcement and search-and-rescue, node identities are not nearly as important as node positions. Such settings have certain characteristics in common. First, node position is very important: knowledge of the physical, as opposed to logical or relative topology, makes it possible to avoid wasteful communication and focus on nodes located within a specific area. Thus, the emphasis is not on the longterm node identity, but rather on current node position. Second, critical environments face security and privacy attacks. Security attacks aim to distribute false location and network ing control information, e.g., routing control messages, or impede the propagation of genuine information. The goal of privacy attacks is to track nodes as they move. Third, when the operating environment is hostile, as is the case in military and law enforcement settings, node identities must not be revealed. We use the term hostile to mean that communication is being monitored by adversarial entities that are not part of the MANET. The need to hide node identities becomes more pressing if we further assume that MANET nodes do not trust each other, due to a suspicious environment where nodes can be compromised. In such an environment, it is natural for node movements to be obscured, such that tracking a given node is impossible or, at least, very difficult. While we do not claim that such suspicious and hostile location-based MANET environments are commonplace, they do occur and require high security and privacy guarantees. While doing all these;there is a challenge for nodes to maintain anonymity protection from outside observers or malicious attackers. Full anonymity protection can be achieved only when ;sources,destinations and routes all are protected. In this work, to offer better anonymity protection, we propose an Anonymous Position-based Security Aware Routing Protocol (APSAR). Experimental results exhibit consistency with the theoretical analysis, and show that APSAR achieves better route anonymity protection compared to other anonymous routing protocols. Also, APSAR achieves comparable routing efficiency to the GPSR geographical routing protocol. The work in this thesis addresses a number of security and privacy issues arising in position-based MANETs. models. We address the problem of position based security aware routing in consideration with better anonymity protection .
Diese Mini Lecture untersucht die Beziehungen von Arbeitsproduktivität und Niedriglohnsektor mit O-Tönen …
Diese Mini Lecture untersucht die Beziehungen von Arbeitsproduktivität und Niedriglohnsektor mit O-Tönen von Christopher Pissarides, Peter Diamond, Robert Solow und James Mirrlees.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Immune checkpoints are an effective way that cancers evade the immune system, but they're not the only one. In the case of pancreatic ductal carcinoma, or PDAC, tumor fibrosis also plays an important role. To understand how fibrosis might translate to poor outcomes among patients with PDAC, researchers examined the ARF6-AMAP1 molecular pathway, which research suggests is activated during fibrosis. Findings revealed that AMAP1 correlated with elevated expression of PD-L1, a molecule that tumor cells present on their surface to elude attack by the immune system. AMAP1 was also linked to elevated fibrosis. Consistently, silencing AMAP1 in a mouse model of human PDAC reduced PD-L1 and fibrosis in their tumors. Suppressing the ARF6-AMAP1, therefore, could be one way to ensure that PDAC tumors can’t hide from immune defenses, offering the prospect of more effective immunotherapies for patients with pancreatic ductal carcinoma..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
Poor research reporting is a major contributing factor to low study reproducibility, …
Poor research reporting is a major contributing factor to low study reproducibility, financial and animal waste. The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines were developed to improve reporting quality and many journals support these guidelines. The influence of this support is unknown. We hypothesized that papers published in journals supporting the ARRIVE guidelines would show improved reporting compared with those in non-supporting journals. In a retrospective, observational cohort study, papers from 5 ARRIVE supporting (SUPP) and 2 non-supporting (nonSUPP) journals, published before (2009) and 5 years after (2015) the ARRIVE guidelines, were selected. Adherence to the ARRIVE checklist of 20 items was independently evaluated by two reviewers and items assessed as fully, partially or not reported. Mean percentages of items reported were compared between journal types and years with an unequal variance t-test. Individual items and sub-items were compared with a chi-square test. From an initial cohort of 956, 236 papers were included: 120 from 2009 (SUPP; n = 52, nonSUPP; n = 68), 116 from 2015 (SUPP; n = 61, nonSUPP; n = 55). The percentage of fully reported items was similar between journal types in 2009 (SUPP: 55.3 ± 11.5% [SD]; nonSUPP: 51.8 ± 9.0%; p = 0.07, 95% CI of mean difference -0.3–7.3%) and 2015 (SUPP: 60.5 ± 11.2%; nonSUPP; 60.2 ± 10.0%; p = 0.89, 95%CI -3.6–4.2%). The small increase in fully reported items between years was similar for both journal types (p = 0.09, 95% CI -0.5–4.3%). No paper fully reported 100% of items on the ARRIVE checklist and measures associated with bias were poorly reported. These results suggest that journal support for the ARRIVE guidelines has not resulted in a meaningful improvement in reporting quality, contributing to ongoing waste in animal research.
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