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In this module, students use several online databases and bioinformatics tools to study the evolutionary conservation of a protein of their choice. Students are first introduced to amino acid chemistry and to some of the theory underlying sequence comparisons. In the exercises, students:learn how amino acid side chain chemistries are reflected in the BLOSUM62 matrix used to identify conserved regions of protein sequencesuse the BLASTP algorithm to compare two homologous protein sequencesconstruct a multiple sequence alignment that compares homologous proteins from multiple speciesThis module is part of a semester-long introductory laboratory course, Investigations in Molecular Cell Biology, at Boston College.
- Subject:
- Biology
- Computer Science
- Genetics
- Material Type:
- Module
- Author:
- Clare OConnor
- Date Added:
- 09/03/2018