This course is offered to undergraduates and addresses several algorithmic challenges in computational biology. The principles of algorithmic design for biological datasets are studied and existing algorithms analyzed for application to real datasets. Topics covered include: biological sequence analysis, gene identification, regulatory motif discovery, genome assembly, genome duplication and rearrangements, evolutionary theory, clustering algorithms, and scale-free networks.

Bacteria often get a bad rap, but they’re some of our best partners in science and medicine! In this episode, we’ll explore what bacteria are doing with their DNA — including how they can trade it around. We’ll learn about chromosomes and plasmids, gene expression and recombinant DNA, and how E. coli are used to make insulin.
Chapters:
Introduction: The Microbiome
Prokaryotes & DNA
Plasmids & Horizontal Gene Transfer
Insulin
Gene Expression
Dr. Rebecca Lancefield
Review & Credits
Credits

Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.

By the end of this section, you will be able to:Describe how changes to gene expression can cause cancerExplain how changes to gene expression at different levels can disrupt the cell cycleDiscuss how understanding regulation of gene expression can lead to better drug design

By the end of this section, you will be able to:Explain the process of epigenetic regulationDescribe how access to DNA is controlled by histone modification

By the end of this section, you will be able to:Understand RNA splicing and explain its role in regulating gene expressionDescribe the importance of RNA stability in gene regulation

By the end of this section, you will be able to:Discuss the role of transcription factors in gene regulationExplain how enhancers and repressors regulate gene expression

By the end of this section, you will be able to:Understand the process of translation and discuss its key factorsDescribe how the initiation complex controls translationExplain the different ways in which the post-translational control of gene expression takes place

By the end of this section, you will be able to:Describe the steps involved in prokaryotic gene regulationExplain the roles of activators, inducers, and repressors in gene regulation

By the end of this section, you will be able to:Discuss why every cell does not express all of its genesDescribe how prokaryotic gene regulation occurs at the transcriptional levelDiscuss how eukaryotic gene regulation occurs at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels

Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.

By the end of this section, you will be able to:Describe how signaling pathways direct protein expression, cellular metabolism, and cell growthIdentify the function of PKC in signal transduction pathwaysRecognize the role of apoptosis in the development and maintenance of a healthy organism

The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology. The assigned readings will provide concrete examples of the experimental approaches and logic used to establish these findings. Some examples of topics include genome and systems biology, transcription, and gene expression.

This outline was created for use with my online Fundamentals of Biology course at West Hills College, Lemoore, CA. It is intended to accompany Concepts of Biology by Open Stax.