This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A critical cellular process that occurs in the wake of a stroke in mice could hint at how to salvage otherwise compromised brain tissue. Strokes happen when the flow of blood to the brain is blocked, most often by a blood clot in a vessel. This creates two zones of injury: a central core and a radiating penumbra. Deprived of oxygen and glucose, brain cells in the core can die within minutes. Those in the penumbra are not as severely damaged. But if blood flow isn’t re-established within hours, those cells will succumb too. That’s why fast responses to strokes are so important—especially among the elderly, who are less resilient than younger sufferers of stroke. New research shows that that disparity between aged and young brains could be due to differences in calcium ion activity brought on by stroke. After inducing stroke in old and young mice, researchers found that spontaneous calcium activity was reduced in the brains of young mice, whereas it was increased in the brains of old mice..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Accumulating evidence suggests that psilocybin – the primary psychedelic compound found in so-called magic mushrooms – can be used to safely treat a range of psychiatric conditions. Prior studies have shown that just one or two doses of psilocybin can have a rapid and lasting positive impact on mental health, but the associated brain mechanisms aren’t well understood. Now, researchers based in the United Kingdom have used functional magnetic resonance imaging to map the brain activity of nineteen patients with treatment-resistant major depression who were given psilocybin. The results shed light on how the compound changes human brain function. The patients were dosed with the drug as part of an open-label clinical trial. Before and one day after treatment, the researchers used fMRI to look at cerebral blood flow and brain functional connectivity – a measure of how different regions of the brain interact..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new clinical trial suggests levosimendan could improve respiratory function in patients with amyotrophic lateral sclerosis. ALS is an adult-onset neurodegenerative disease that results in progressive weakness. Those affected by the disease typically die within three to four years of diagnosis due to respiratory failure commonly resulting from weakening of the diaphragm. Prior studies indicate that levosimendan – a calcium sensitizer on the market since 2000 for the treatment of acute worsening of severe heart failure – can also boost the force and efficiency with which the diaphragm contracts. This prompted researchers to investigate whether levosimendan is clinically beneficial to those with ALS. The phase 2 trial used a randomized, double-blind, placebo-controlled, crossover design to evaluate the efficacy and safety of oral levosimendan in 66 patients with ALS..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Much research on epilepsy treatment has focused on properly identifying the epileptogenic zone, the area of the brain where a seizure initiates. This zone, previous studies have found, can potentially be recognized by high-frequency activity, or “fast activity,” that occurs in a brain area right after seizure onset. However, this method does not accurately delineate the epileptogenic zone from other normal brain tissues. A new paper published in Human Brain Mapping examines how a different marker, or “fingerprint,” can be used to accurately identify the epileptogenic zone, whether this fingerprint can be seen in different types of brainwaves, and, finally, how the method compares to using fast activity. The study builds on a previous paper published by the authors, in which the fingerprint itself was identified as a specific pattern of brain activity observed in seizure patients..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

The last epic tale of a lost soul

Word Count: 23878

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

A poster presented at the BioQUEST Wicked Problems Workshop Summer 2018 on a case study in progress.

Short Description:
Visual depictions of the health care professions often do not include ethnoculturally diverse therapists and patients. Stock videos and photos can also be expensive, limiting access to high quality resources to those who can afford to pay. We developed an online library to house photos that depict therapists and patients from diverse backgrounds performing physiotherapy skills and engaging in healthcare-related activities. The Diversity Exchange is one way to enhance teaching and learning by integrating anti-racist and anti-oppressive pedagogy ensuring our culture and practices resist and dismantle institutional racism, rather than reproducing it.

Word Count: 4666

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Recent studies have shown that all-inside repair of meniscal ramp lesions can restore normal knee motion. But it has remained unclear how ramp lesion repairs affect ACL in situ forces and bony contact forces. To remedy that, researchers from the University of Pittsburgh recently used a robotic system to examine these forces in intact knees, knees with ramp lesions, and knees with ramp lesion repairs. Their findings, reported in the November issue of the American Journal of Sports Medicine, suggest that the indications for ramp lesion repair may be limited. The team looked at nine knees from human cadavers, each tested using a six-degree-of-freedom robotic system. The knees were continuously flexed from full extension to 90° under five different loads: an anterior load, an external-rotation torque, a combined anterior and compression load, and a combination of external- or internal-rotation torque and compression..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The timing of return to play is one of the most critical decisions made following ACL reconstruction. Returning too early carries the risk of graft failure, while returning too late could cost patients financial and athletic opportunities. Unfortunately, no universal, objective method exists to determine the best time for athletes to resume full activities. But according to a new study reported in The American Journal of Sports Medicine, such methods could be on the horizon, with the help of MRI technology. One promising marker for estimating the best time for athletes to return to play is ACL graft maturation. That’s the process by which a surgical graft makes the transformation from tendon tissue into a substance similar to a normal ACL. The problem is that this transformation is difficult to track over time. Tissue biopsies are currently the gold standard, but are invasive and, in most cases, impractical to perform..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In this lesson, students will closely analyze the structure of their document, identifying claims, reasons, evidence, and implied or explicit counterarguments. They'll also evaluate the argument made.

The health of the watershed has a direct impact on the health of those that use it. This unit introduces students to the concept that imbalances and contaminants in the watershed can cause disease and infection in humans. The first part of this unit begins with an introduction to the major concept of a watershed and how humans can have a direct impact on the chemicals and organic matter that are carried within. Students study how chemical contaminants including mercury, nitrogen, arsenic, and lead are introduced into the watershed and the clinical presentation of these contaminants in humans. Each contaminant includes real-world case studies—including the arsenic ground-water contamination in Bangladesh and the lead pipe incident in Washington DC.

Students will also learn about microbial pathogens including coliform bacterial species, Naegleria fowleri , and Cryptosporidium . All pathogens include examples of how they are introduced into the watershed, how they infect humans, and how to remediate these pathogens. Sample case study formats for the presentation of this material are included in the activities section, along with labs that students can perform.

Introduction to the egg, sperm, and fertilization. Created in collaboration between the Association of American Medical Colleges and Khan Academy.

With the emerging genetic testing companies such as “23 and Me” and “Ancestry”, it is becoming more popular and accessible for families to test their own genes rather than from a primary care provider. The purpose of this activity is to analyze multiple angles of genetic testing. Students will look at multiple areas of health including mental, emotional, and physical health and how it can impact their personal health and the health of loved ones.

This multimodal text set is designed to help middle school learners work toward mastering the grade-level moderately complex Anchor Text “Vaping: Not for the Young Heart”, adapted from a published study that discusses the cardiovascular risk associated with vaping (Moheimani RS, Bhetraratana M, Yin F, et al., 2017 & Middlekauff, H. R., 2019).

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Light-responsive proteins have revolutionized our understanding of the brain. By introducing the genes encoding these proteins into neurons and then exciting the cells using lasers – a technique known as optogenetics – individual cells can be rapidly turned on or off, enabling exquisitely sensitive investigations of brain function. But a fundamental limitation of the method is that light doesn’t travel very far through brain tissue, which has hampered the study of more buried – and often vital – structures. Now, researchers at the RIKEN Center for Brain Science have developed a way to extend the reach of optogenetics by nearly an order of magnitude, providing new possibilities for deep-brain stimulation. The team accomplished this using a special type of nanoparticle known as an upconversion nanoparticle, so named for its ability to transform – or “upconvert” – near-infrared light into visible output..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This video presents the structure and functions of ligaments, joints, and tendons. Created by Tracy Kim Kovach.

In this video we explore the organization of the nervous system, and its division into the central nervous system and peripheral nervous system. Created by Matthew Barry Jensen.

Innate vs. adaptive immunity. Humoral adaptive immunity vs. cell-mediated adaptive immunity. Created by Sal Khan.

Introduction to the human reproductive system. Created in collaboration between the Association of American Medical Colleges and Khan Academy.