Students learn how engineers apply their understanding of DNA to manipulate specific genes to produce desired traits, and how engineers have used this practice to address current problems facing humanity. They learn what genetic engineering means and examples of its applications, as well as moral and ethical problems related to its implementation. Students fill out a flow chart to list the methods to modify genes to create GMOs and example applications of bacteria, plant and animal GMOs.

The MIT Biology Department core Introductory Biology courses, 7.012, 7.013, 7.014, 7.015, and 7.016 all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. The focus of 7.013 is on genomic approaches to human biology, including neuroscience, development, immunology, tissue repair and stem cells, tissue engineering, and infectious and inherited diseases, including cancer.

The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.
7.014 focuses on the application of these fundamental principles, toward an understanding of microorganisms as geochemical agents responsible for the evolution and renewal of the biosphere and of their role in human health and disease.
Acknowledgements
The study materials, problem sets, and quiz materials used during Spring 2005 for 7.014 include contributions from past instructors, teaching assistants, and other members of the MIT Biology Department affiliated with course 7.014. Since the following works have evolved over a period of many years, no single source can be attributed.

The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. 7.013 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), developmental biology, neurobiology and evolution.
Biological function at the molecular level is particularly emphasized in all courses and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.

This exercise is designed to help undergraduates understand cellular macromolecules and the monomer/polymer relationships important for cells. The exercise is designed to be performed in class, and includes a guided note-taking table and some short-answer questions that students complete independently to evaluate the structures of sugars and DNA.

This lesson uses the fundamentals of protein synthesis as a context for investigating the closest living relative to Tyrannosaurus rex and evaluating whether or not paleontologist and dinosaur expert, Jack Horner, will be able to "create" live dinosaurs in the lab. The first objective is for students to be able to access and properly utilize the NIH's protein sequence database to perform a BLAST, using biochemical evidence to determine T rex's closest living relative. The second objective is for students to be able to explain and evaluate Jack Horner's plans for creating live dinosaurs in the lab. The main prerequisite for the lesson is a basic understanding of protein synthesis, or the flow of information in the cell from DNA to RNA during transcription and then from RNA to protein during translation

This course introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, rigorous data analysis, and scientific communication form the underpinnings of this subject. Three discovery-based experimental modules focus on genome engineering, expression engineering, and biomaterial engineering.
This OCW site is based on the source OpenWetWare class Wiki, found at 20.109(F07): Laboratory Fundamentals of Biological Engineering.

One of the fastest-growing areas of medical research is that of genetic testing and gene therapy. This chapter introduces students to this area of DNA research and helps them explore the related ethical issues. Scientists have recently completed a preliminary ‰ŰĎmap‰Ű of all the genes in the human body. This is also known as the Human Genome Project and consists of all the sequences of DNA chemical units that tell a cell how to behave. This accomplishment has incredible benefits. However, it also raises new, complex issues that society cannot ignore.

Rather than focus on the scientific details of this discovery, this chapter gives an overview of the important concepts related to DNA's initial discovery and later research conducted in this field. Teachers can use the lesson plans and materials to help students understand these fundamental concepts and gain a command of the vocabulary necessary to discuss them. Given the amazing advances in biological research and the new knowledge that has become available to human beings about their own biological makeup, it is important for students to know basic concepts related to DNA research and the human genome project. This following lesson provides a basic introduction to this topic in an interactive fashion.

Biotechnology is perhaps the most rapidly advancing area in science today. The Advances in Biotechnology volume has been created to provide language teachers with resources about breakthroughs in biotechnology. Each chapter of the volume highlights one aspect of research in the field of DNA and genetics along with its applications to and implications for society. The chapters feature relevant background information on each topic, interactive and communicative classroom activities, and a list of related print and Internet resources that will allow teachers to expand the lesson further.

Roles of DNA polymerase, primase, ligase, helicase and topoisomerase in DNA replication. An explanation of leading and lagging strands.

In this activity on page 1 of the PDF, learners compare the relative sizes of biological objects (like DNA and bacteria) that can't be seen by the naked eye. Learners will be surprised to discover the range of sizes in the microscopic world. This activity can be followed up with a second activity, "What's in a microbe?", located on page 3 in the same resource.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Hydrothermal vents in the deep sea spew noxious chemicals like hydrogen sulfide at temperatures of up to 750°F, and yet they’re teeming with life. But what happens when these underwater chimneys stop smoking? That’s what researchers exploring vents in the Eastern Pacific set out to discover. The team compared DNA between microbes inhabiting an active sulfide chimney, and microbes colonizing a chimney that went extinct in 2006 due to a volcanic eruption. A look at the genes responsible for converting fuel (energy) into food revealed a crucial distinction. While the live chimney was dominated by microbes feeding on chemicals in the super-hot fluid, the dormant chimney was rich with microbes metabolizing solid minerals. Remarkably, that dietary switch appeared to flip within the first few years of the chimney’s extinction and could likely remain stable for thousands of years..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Endometrial cancer is the most common form of uterine cancer and is most frequently diagnosed in women over 55. A new study proposes a key mechanism that promotes the formation of endometrial tumors. It starts with ERα, one of two receptors activated by the sex hormone estrogen. Experiments on human cancer cells showed that activating ERα significantly increased the expression of the protein PIWIL1, which is detected in different forms of cancer in both men and women. A closer look revealed that ERα binds to a unique site of the PIWIL1 gene known as a half-ERE. That binding signals the expression of the PIWIL1 protein and thereby promotes tumor growth. Understanding how this estrogen-stimulated pathway works in the female body could help researchers and clinicians expand treatment options available to women with endometrial cancer..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In this activity, learners explore the "nuts and bolts" of gene chips. Learners construct a simple model of a DNA microarray (also known as gene chips) and learn how microarrays can be used to identify and treat disease--including cancer. This resource includes references and an explanation of microarrays.

At the beginning of a DNA, DNA replication, and mitosis unit, students are given a short science news article summarizing a recent research paper. This assignment links the article to figures and key techniques from a related journal article, requiring students to apply and transfer the knowledge they gained in the unit.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Wastewater treatment plants are a critical piece of infrastructure that depend on microbes, both resident and incoming. Incoming microbes can be beneficial but may include parasites that need to be removed. Resident microbes, meanwhile, help break down organic waste. While much is known about bacteria in wastewater treatment plants, eukaryotes are frequently overlooked. Recently, researchers examined the whole microbiome of 10 wastewater treatment plants in Switzerland. They utilized metagenomics to measure which microbes were present and metatranscriptomics to analyze their activity. Bacteria were the most numerous— but eukaryotes, particularly protists, showed the most activity, and there was a surprising number and range of active parasites, which were particularly prevalent in the inflow. Network analysis suggested predation by resident microbes likely helped remove parasites..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Students will breed fruit flies through several generations and record their data using mathematical models in order to demonstrate the inheritance of trait variations.

Discover what controls how fast tiny molecular motors in our body pull through a single strand of DNA. How hard can the motor pull in a tug of war with the optical tweezers? Discover what helps it pull harder. Do all molecular motors behave the same?