In this presentation we’ll present a genetic atlas of the non-autoimmune diabetes and describe monogenic forms of diabetes.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Limiting the debilitating consequences of ageing is a major medical challenge of our time. Robust pharmacological interventions that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathways. Here we report results from the Caenorhabditis Intervention Testing Program in assessing longevity variation across 22 Caenorhabditis strains spanning 3 species, using multiple replicates collected across three independent laboratories. Reproducibility between test sites is high, whereas individual trial reproducibility is relatively low. Of ten pro-longevity chemicals tested, six significantly extend lifespan in at least one strain. Three reported dietary restriction mimetics are mainly effective across C. elegans strains, indicating species and strain-specific responses. In contrast, the amyloid dye ThioflavinT is both potent and robust across the strains. Our results highlight promising pharmacological leads and demonstrate the importance of assessing lifespans of discrete cohorts across repeat studies to capture biological variation in the search for reproducible ageing interventions.

By the end of this section, you will be able to:Explain transformation of DNADescribe the key experiments that helped identify that DNA is the genetic materialState and explain Chargaff’s rules

Genetic Engineering interactive learning website that includes:
Journey of a Gene - Learn the steps of genetic engineering to help us make soybeans that are resistant to Soybean Sudden Death Syndrome.
Enviropig - Learn the steps of genetic engineering to help us make environmentally friendly pigs.
Genetic Engineering: Oomycete - Learn the steps of genetic engineering used in the process of developing oomycete resistant soybean.
Farmers, Consumers, and GMOs - The world in which we live is constantly changing. Farmers and consumers need to adapt in order to deal with those changes. The use of genetically modified organisms (GMOs) is one way to help them with adapting. The purpose of this learning environment is to provide the knowledge necessary to assist farmers and consumers to navigate through our changing world.

In this video collaboration from Khan Academy and 23andMe, you'll learn how chromosomes and genes are passed down from parent to child.

This presentation provides an introduction to the genetics behind the common forms of type 2 diabetes. Furthermore we’ll provide an introduction to the Genome-Wide Association Study, this study is a hypothesis generating method that contains a discovery and a replication sample.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This blog post, written by Frieda Reichsman, discusses how educators can implement three-dimensional teaching methods into classrooms and meet the Next Generation Science Standards. The article introduces the 3D Teacher Moves Table, a lesson-planning tool created by Hedi Lauffer at Wisconsin Fast Plants, as a guide for high school biology teachers to use when developing lessons and curricula to support students' data analysis skills. Additionally, this article introduces a lesson investigation using Fast Plants and data analysis, where educators can implement the 3D Teacher Moves Table. The Biological Variation in Fast Plants Lesson Plan can be available to view separately.

In this video collaboration from Khan Academy and 23andMe, you'll learn how chromosomes and genes are passed down from parent to child.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Medulloblastoma accounts for one-quarter of all pediatric brain tumors. A recent study urges genetic and transcriptomic analyses to reveal pathways driving tumor growth and possible resistance to conventional therapy. The team behind the study tracked the evolution of medulloblastoma in two pediatric patients one with familial adenomatous polyposis (FAP) and the other with Li-Fraumeni syndrome (LFS). The patient with FAP was originally diagnosed with the classical variant nonWNT/nonSHH medulloblastoma and received standard radiation therapy followed by chemotherapy. Approximately four years after radiotherapy, the patient showed an epidural mass. Approximately four years after radiotherapy, the patient showed an epidural mass. Similarly, the patient with LFS showed a tumor treated as a high-risk medulloblastoma. Ten months after receiving radiation therapy, the patient developed a sarcoma that showed signs of being caused by that very therapy..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

By the end of this section, you will be able to:Explain the relationship between genotypes and phenotypes in dominant and recessive gene systemsDevelop a Punnett square to calculate the expected proportions of genotypes and phenotypes in a monohybrid crossExplain the purpose and methods of a test crossIdentify non-Mendelian inheritance patterns such as incomplete dominance, codominance, recessive lethals, multiple alleles, and sex linkage

By the end of this section, you will be able to:Explain systems biologyDescribe a proteomeDefine protein signature

By the end of this section, you will be able to:List the different steps in prokaryotic transcriptionDiscuss the role of promoters in prokaryotic transcriptionDescribe how and when transcription is terminated

This document uses headings to allow students to begin the search with either the codon or the amino acid.

By the end of this section, you will be able to:Explain pharmacogenomicsDefine polygenic

By the end of this section, you will be able to:List the steps in eukaryotic transcriptionDiscuss the role of RNA polymerases in transcriptionCompare and contrast the three RNA polymerasesExplain the significance of transcription factors

By the end of this section, you will be able to:Describe the scientific reasons for the success of Mendel’s experimental workDescribe the expected outcomes of monohybrid crosses involving dominant and recessive allelesApply the sum and product rules to calculate probabilities