This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Chronic infection with the hepatitis C virus is a major cause of chronic liver disease, even after the virus has been eradicated by antiviral treatment. The problem appears to lie in the lingering activation of harmful Wnt/β-catenin signaling, which active viruses exploit for replication. A new study suggests the enzyme PKA could play a role. PKA is part of a signaling cascade that is activated during hepatitis C infection. To determine its role, researchers prevented PKA activation by treating cells with a PKA inhibitor. Inhibition was found to be beneficial. Inhibiting PKA reduced cells’ capacity to support both the hepatitis C virus and Wnt/β-catenin signaling, as mediated by another enzyme, GSK-3β. Interestingly, similar benefits were observed when another harmful effect of viral infection was repressed, namely, endoplasmic reticulum stress..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 05/15/2023