This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Accurate identification of medical alarm sounds can be life-saving, but current standard alarms are difficult to learn. One issue is that these alarms, despite having different melodies, possess highly similar tonal qualities. This makes it hard to distinguish, for example, an alarm indicating an abnormal heart rate from one denoting abnormal oxygen saturation. To ease interpretation, researchers have developed new auditory icon alarms. These real-world sounds are associated with the processes they represent, such as the sound made by pills rattling in a bottle to indicate a drug administration issue or the sound of assisted breathing to denote abnormal ventilation parameters. The intuitive reaction to such sounds should make the icon alarms easier to identify than standard alarms, creating new possibilities to improve patient safety. The team tested the usability of the icons in a simulated intensive care unit..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Delirium, or a confused or disoriented state that can affect attention, awareness and cognition, is common in elderly patients following surgery -- and is a leading cause of postoperative complications among elderly hospitalized patients. But it’s not clear why this happens or which patients are at especially high risk. In particular, certain electroencephalogram (E-E-G) patterns during anesthesia known as burst-suppression have been associated with postoperative delirium. These patterns are characterized by spikes in electrical activity, or bursts, alternating with longer periods of no activity. But whether burst-suppression plays a causal role in delirium isn’t known. A study, now published in the journal Anesthesiology by researchers in Boston, finds that in elderly patients undergoing cardiopulmonary bypass, burst-suppression is associated with delirium. The project was a sub-study of the ongoing MINDDS trial, and retrospectively looked at the outcomes of 159 patients over the age of 60..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"An international team of researchers is looking at ways to prevent cognitive impairment following the use of general anesthetics. Their work could lead to better outcomes for the over 312 million surgical patients who undergo anesthesia each year. General anesthetics are associated with the occurrence of postoperative delirium. This complication – often marked by inattention, memory disturbances and confusion – makes it hard for surgical patients to resume daily living activities, and has even been linked to an increased risk of death. The drug dexmedetomidine helps prevent postoperative delirium, but the biological basis for this protection isn’t clear. The researchers previously reported that a single exposure to the common anesthetic etomidate can trigger long-lasting changes to an inhibitory receptor in the brains of mice. Specifically, etomidate increased the number of α5 GABAA receptors expressed on the surface of neurons..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"It may be surprising to learn that drugs like morphine can actually make it harder to heal from injuries, including surgery. Researchers report that using opioids to manage this type of acute pain can make the pain last longer, potentially drawing out the need for pain relief. Although it’s unclear exactly why this happens, scientists are beginning to uncover some of the physiological causes of this delayed healing. And they think it has something to do with the brain’s immune system. That conclusion comes from an in-depth look at how morphine affects recovery in mice. Using a mouse model of orthopedic surgery, researchers looked at the consequences of postoperative morphine use. Mice were subjected to tibial fracture and repair and given a 7-day course of either morphine or an inactive vehicle. Some mice underwent a sham operation – they were anesthetized and received skin incisions, but no bone fracture – followed by the same treatment regimen..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.