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Analysis of Biological Networks (BE.440)
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This class analyzes complex biological processes from the molecular, cellular, extracellular, and organ levels of hierarchy. Emphasis is placed on the basic biochemical and biophysical principles that govern these processes. Examples of processes to be studied include chemotaxis, the fixation of nitrogen into organic biological molecules, growth factor and hormone mediated signaling cascades, and signaling cascades leading to cell death in response to DNA damage. In each case, the availability of a resource, or the presence of a stimulus, results in some biochemical pathways being turned on while others are turned off. The course examines the dynamic aspects of these processes and details how biochemical mechanistic themes impinge on molecular/cellular/tissue/organ-level functions. Chemical and quantitative views of the interplay of multiple pathways as biological networks are emphasized. Student work culminates in the preparation of a unique grant application in an area of biological networks.

Subject:
Applied Science
Biology
Engineering
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Essigmann, John
Sasisekharan, Ram
Date Added:
09/01/2004
The Brain and Cognitive Sciences I
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CC BY-NC-SA
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Survey of principles underlying the structure and function of the nervous system, integrating molecular, cellular, and systems approaches. Topics: development of the nervous system and its connections, cell biology or neurons, neurotransmitters and synaptic transmission, sensory systems of the brain, the neuro-endocrine system, the motor system, higher cortical functions, behavioral and cellular analyses of learning and memory. First half of an intensive two-term survey of brain and behavioral studies for first-year graduate students.

Subject:
Biology
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Brown, M.
Graybiel, Ann
Miller, Earl
Schiller, Peter
Wilson, Matt
Date Added:
09/01/2002
Cell and Molecular Neurobiology
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CC BY-NC-SA
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This course explores the major areas of cellular and molecular neurobiology, including excitable cells and membranes, ion channels and receptors, synaptic transmission, cell-type determination, axon guidance, neuronal cell biology, neurotrophin signaling and cell survival, synapse formation and neural plasticity. Material includes lectures and exams, and involves presentation and discussion of primary literature. It focuses on major concepts and recent advances in experimental neuroscience.

Subject:
Biology
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Constantine-Paton, Martha
Quinn, William
Sheng, Morgan
Date Added:
02/01/2008
Exercise and the Brain
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CC BY-NC-SA
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This chapter covers the correlation between exercise and brain function. It focuses on how different fitness levels can create postiive and negative variations in brain function as well as changes in brain function over the lifespan. It mentions many different topics of neuroscience and references numerous articles related to the subject matter, including some detailed descriptions of the study's procedure and findings. It is text-book format. 

Subject:
Biology
Health, Medicine and Nursing
Life Science
Material Type:
Textbook
Unit of Study
Author:
Mercedes Clark
Mason Shepard
Qiansheng Zhan
Robert Pearce
Date Added:
05/04/2023
Gastroenterology
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CC BY-NC-SA
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The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, with emphasis on integrating the molecular, cellular and pathophysiological aspects of the disease processes to their related symptoms and signs.

Subject:
Anatomy/Physiology
Applied Science
Health, Medicine and Nursing
Life Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Carey, Martin
Chung, Daniel
Chung, Raymond
Glickman, Jonathan
Date Added:
09/01/2005
High levels of the protein SIX1 indicate that gastric cancer has grown deadly
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Researchers have identified a gene important to the growth and spread of gastric cancer, opening the door to new understanding of this deadly disease. The gene, known as SIX1, has been implicated in disease progression in several cancers, but its link to gastric cancer wasn’t clear. This ambiguity prompted researchers at China Medical University to take a closer look at the role of SIX1 in gastric cancer cells. The team started by measuring SIX1 protein expression in gastric tumors and adjacent non-tumor tissue collected from 208 patients. They found high levels of SIX1 in nearly half the tumor samples and virtually none in the non-cancerous tissue – a pattern suggesting that SIX1 is an important biomarker for gastric cancer. This notion was supported by the finding that patients with higher levels of SIX1 had more advanced disease than those with moderate SIX1 expression..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/20/2019
Neural Plasticity in Learning and Development
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CC BY-NC-SA
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Roles of neural plasticity in learning and memory and in development of invertebrates and mammals. An in-depth critical analysis of current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Discussion of original papers supplemented by introductory lectures.

Subject:
Biology
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Liu, Guosong
Miller, Earl
Quinn, William
Tonegawa, Susumu
Wilson, Matt
Date Added:
02/01/2002
Pulling a Car With Yucca
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CC BY
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Can you pull a car with cordage made just from a plant? We put it to the test! This clip with Jefferson Patterson Park and Museum's Educator Nate Salzman provides a simple demonstration proving that a cell's microscopic structure affects its macroscopic properties. Included in the video is the very simple method needed to produce and test cordage from yucca leaves on your own.

If you're thinking of using this in a classroom, considering pairing this exploration of cells' structures with an engineering challenge! Yucca fiber can be made without boiling the leaves, if needed: students can either pound/mash leaves to isolate fibers or fibers can be peeled from wet leaves and used while still "green" (any cordage made from green fibers will loosen as it dries, however).

This resource is part of JPPM’s open educational resources project providing education content from our in-house educators, horticulturalists, curators, and conservationists at our 560 acre public park. The grounds have provided a home for different peoples for over 10,000 years and includes extensive archaeological sites, multiple ecosystems, and a 1930s farmstead designed by architect Gertrude Sawyer for the park’s namesake, Jefferson Patterson.

Subject:
Applied Science
Biology
Botany
Engineering
Environmental Science
Life Science
Material Type:
Activity/Lab
Lecture
Provider:
Jefferson Patterson Park and Museum
Author:
JPPM Admin
Date Added:
10/01/2021