Biology is designed for multi-semester biology courses for science majors. It is …
Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.
By the end of this section, you will be able to:Explain how …
By the end of this section, you will be able to:Explain how the binding of a ligand initiates signal transduction throughout a cellRecognize the role of phosphorylation in the transmission of intracellular signalsEvaluate the role of second messengers in signal transmission
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Phosphorylated STAT1 (P-STAT1) is an important mediator of interferon-induced antiviral immunity. During interferon signaling, P-STAT1 dimerizes and accumulates in the nucleus with the help of the protein importin to affect gene transcription and elicit immune responses. In a positive feedback loop, P-STAT1 also induces further STAT1 expression, thereby increasing the cytoplasmic levels of unphosphorylated STAT1 (U-STAT1), a protein that regulates apoptotic cell death. However, the impact of U-STAT1 on the P-STAT1-mediated immune response is unclear. To learn more, researchers recently cotransfected cells with wild-type P-STAT1 and a permanently unphosphorylated U-STAT1 mimic. Interestingly, the U-STAT1 mimic prevented nuclear accumulation of P-STAT1 during interferon gamma (IFNγ) stimulation, but it didn’t impair downstream P-STAT1 signaling, indicating that some P-STAT1 could still enter the nucleus to exert its effects..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
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