Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.
By the end of this section, you will be able to:Explain cross-reactivityDescribe the structure and function of antibodiesDiscuss antibody production
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Neutrophil extracellular traps, or NETs, are stringy chromatin networks that are ejected from immune cells to capture and neutralize harmful pathogens. But over-casting NETs can be indicative of disease, including cancer and thrombosis. As a result, NETs have become a promising non-invasive biomarker, and one way to quantify these networks is by detecting a critical component of NETs— histones whose arginine residues have been converted to citrulline, or H3Cit. These assays use antibodies to measure H3Cit in patient plasma, but a recent study shows that existing assays are limited by two important factors: Part of the problem is that available antibodies to H3Cit display low specificity, poor signal-to-noise, and lot variability. The second issue is that these assays are calibrated using enzymatically citrullinated, free histone peptides, which are unstable in human plasma and produce variable performance between batches..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.