This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Neddylation is the process by which the molecule NEDD8 is attached to cellular proteins. Elevated neddylation in the body has been linked to various cancers. Inhibiting this protein modification has therefore become a promising anticancer strategy. A new study describes how researchers used this anti-neddylation approach to kill esophageal cancer cells. The team treated lab-grown esophageal cancer cells with MLN4924, a known neddylation inhibitor. They found that MLN4924 indirectly led to the programmed cell death, or apoptosis, of the cancer cells. By reducing neddylation, MLN4924 actually promoted a cell survival mechanism known as autophagy. Autophagy keeps cells healthy and alive by clearing harmful debris. Interestingly, it also gave the researchers access to a “kill switch” for diverting from autophagy to apoptosis. That switch came in the form of the protein ATF3, which can be silenced to cause cell death..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 10/28/2020
