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Antibiotic exposure disrupts the metabolic development of the microbiome in preterm infants
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The period shortly after birth is a critical window for microbiome establishment. Antibiotics can impact this process, often negatively, but most of the research to date has been conducted on full-term infants and has rarely included infants that never received antibiotics, complicating the analysis. A recent study sought to close these gaps and examined the skin and gut microbiomes of preterm infants. While gestational age at birth had some influence on the maturation of the microbiome, postnatal age had a stronger impact. But brief exposure to antibiotics reversed the maturation trajectory between weeks one and three after birth, and antibiotic exposure impacted the abundance of potentially beneficial gut microbes. Some bacteria in our microbiome generate short-chain fatty acids, like butyrate and acetate, that our cells can use, but at three weeks after birth, the antibiotic-exposed infants had an altered microbiome with reduced capacity to produce these important metabolites..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
04/14/2023
Bacteria and viruses are not inherited equally from mother to child at birth
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The birth of a child involves many big transitions, but one of these changes occurs inside the child, who transitions from the sterile womb to an outside environment full of microbes. While this has lasting effects on growth, inflammation, and immunity, remarkably little is known about how gut bacteria and viruses are acquired by infants. Recently, researchers used next-generation sequencing to evaluate microbes from the guts of 28 pairs of twins and their mothers. They found that the majority of the infant’s gut bacteria were similar to their mother’s gut bacteria. Viruses were less similar, suggesting they might be transmitted through other routes. Twins also shared more of their gut microbiota with each other, emphasizing the strong effect of environmental exposure, and mode of delivery had very little effect on how much of the infants’ gut microbiome was inherited from their mothers..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/05/2020
Early Childhood Curriculum Models
Conditional Remix & Share Permitted
CC BY-NC-SA
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This lesson introduces students to different curriculum models, Montessori and HighScopes, used in early childhood settings. Students will identify important details to each model, then identify similarities and differences in curriculum as the child ages. Students will end the lesson by developing an opinion on which model they believe to be the best.

Subject:
Career and Technical Education
Early Childhood Development
Material Type:
Activity/Lab
Lesson Plan
Author:
Sarah Hubel
Date Added:
07/23/2023
Not all antibiotics increase fungi in the gut: Focus on amoxicillin-clavulanic acid
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antibiotics are known to impact the bacteria in our gut microbiome, but their impact on gut fungi has been understudied. It is thought that antibiotics increase the fungal population by decreasing the competition from bacteria for nutrients. But a recent study found that the antibiotic amoxicillin-clavulanic acid has the opposite effect. By examining samples from mice and a small number of human infants, researchers found that this treatment triggered a decrease in intestinal fungi. The treatment also led to a total remodel of the fungal and bacterial population structures in the mouse gut microbiomes. Specifically, the fungal community gained a higher proportion of Aspergillus, Cladosporium, and Valsa groups, and the bacterial community had an increase in bacteria belonging to Enterobacteriaceae. Many Enterobacteriaceae reduce the fungal growth but among them E. hormaechei was particularly active in vitro and in vivo..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
04/17/2023