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Serotonin activates pro-cancer cell signaling and drives progression in colorectal cancer
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"While best known for its role in the brain, serotonin does more in our body than influence mood. There is even growing evidence that it is involved in tumor development. However, little is known about its role in colorectal cancer. In a recent study, researchers found that serotonin promotes colon cancer cell growth in cell culture and animal models. Further tests revealed that serotonin is moved into colorectal cancer cells via its transporter SERT and that once the serotonin is inside the cancer cells, the enzyme TG2 links serotonin to the protein RhoA, activating it. Through down-stream signaling mediators, activated RhoA increases expression of the known cancer-promoting protein YAP. Blocking SERT from transporting serotonin with citalopram reversed the serotonin-induced YAP expression and cell proliferation increases and blocked serotonin’s effects on tumor formation in mice..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Life Science
Material Type:
Research Square
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Video Bytes
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