This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Alirocumab, a drug that inhibits PCSK9 and helps clear the blood of atherogenic lipids, may be of benefit for individuals with type 2 diabetes who are most at risk of cardiovascular disease. According to the International Diabetes Federation, heart disease is the leading cause of death among people with type 2 diabetes. One factor that might contribute to that grim statistic is the high mixed dyslipidemia prevalence in this population. Mixed dyslipidemia is characterized by elevated triglycerides, and hence high triglyceride-rich lipoprotein, or remnant cholesterol, and high cholesterol levels; and low serum levels of high-density lipoprotein cholesterol, or HDL-C. Despite treatment with statins and other lipid-lowering therapies targeting atherogenic lipoproteins, management of mixed dyslipidemia remains challenging, especially among individuals with diabetes..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.

By the end of this section, you will be able to:Describe the four major types of lipidsExplain the role of fats in storing energyDifferentiate between saturated and unsaturated fatty acidsDescribe phospholipids and their role in cellsDefine the basic structure of a steroid and some functions of steroidsExplain the how cholesterol helps to maintain the fluid nature of the plasma membrane

By the end of this section, you will be able to:Describe the four major types of lipidsExplain the role of fats in storing energyDifferentiate between saturated and unsaturated fatty acidsDescribe phospholipids and their role in cellsDefine the basic structure of a steroid and some functions of steroidsExplain the how cholesterol helps to maintain the fluid nature of the plasma membrane

By the end of this section, you will be able to:Explain why carbon is important for lifeDescribe the role of functional groups in biological molecules

By the end of this section, you will be able to:Explain why carbon is important for lifeDescribe the role of functional groups in biological molecules

This module provides an introdcution to the concepts of fats and proteins. The basic chemical structure of fats as triglycerides is reviewed, and an introduction to protein structure, including the peptide bond is given.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The gut microbiota influences many physiological processes in mammals, and disruption of this diverse bacterial community can impair liver function, leading to disease. However, the molecular mechanisms of gut microbiota–intestine–liver communication are unclear. By analyzing public hepatic transcriptomics datasets, researchers recently identified pregnane X receptor (PXR) as a regulator of many differentially expressed genes in microbe-free vs. normal mice. The PXR target genes were largely associated with xenobiotic metabolism. Additional experiments in mice revealed that PXR deletion induced sex-specific changes in gut microbiota composition and hepatic gene expression. Microbiota depletion with antibiotics also induced PXR-dependent alterations in hepatic gene expression that differed between male and female mice. Further studies in male mice confirmed that elimination of the microbiota altered hepatic lipid and xenobiotic metabolism, and this effect was dependent on the presence of PXR..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.