Diabetes - The Essential Facts - What Role Does Overweight and Obesity Play ? (17:27)

(View Complete Item Description)

This presentation address how being overweight and obese is considered one of the strongest predictors, regarding the development of type 2 diabetes. Almost 85 % of people living with diabetes type 2, are either overweight or obese. This is an important aspect, because globally we have a lot of overweight people, in fact in 2014, one in three adults was overweight and one in eight was obese. But why do the numbers keep growing and what’s causing this epidemic growth of obesity? Narrator: Richard Steed.

Material Type: Lecture

Authors: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen, Professor Arne Astrup, Professor Jens Juul Holst, Professor Steven Bloom

Diabetes - A Global Challenge - Physical Inactivity - A Major Risk Factor for Diabetes (16:46)

(View Complete Item Description)

This presentation aims to increase the students knowledge of physical inactivity and how it’s a major risk factor for developing diabetes, independent of body weight. Moreover we’ll discuss how we fight the global burden of a physical inactive lifestyle. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Bente Klarlund Pedersen

Diabetes - A Global Challenge - Epidemiology of Diabetes Part 3 (05:50)

(View Complete Item Description)

This presentation tries to identify the most important risk factors for developing diabetes. In order to take the next steps in planning diabetes prevention, we need to know what distinguished those at risk of developing diabetes from those who aren’t or are at lower risk within the populations. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Thorkild I. A. Sørensen

Diabetes - A Global Challenge - Physical Activity and its Influence on Obesity, Insulin Resistance and Diabetes Part 2 (22:16)

(View Complete Item Description)

This presentation provides an introduction to physical activity and its influence on obesity, insulin resistance and diabetes type 2. Furthermore we’ll talk about how we can measure body fat distribution, insulin sensitivity and insulin resistance. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Bente Stallknecht

Diabetes - A Global Challenge - Physiological Regulation of Blood Glucose Part 1 (25:57)

(View Complete Item Description)

This presentation talks about glucose regulation, how it’s possible to maintain a constant glucose level and physical regulation of plasma glucose. In continuation of this we’ll talk about diabetic complication, like neuropathy, retinopathy, nephropathy, chronic hyperglycemia, which can lead to myocardial infarction, stroke and amputations. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Jens Juul Holst

Diabetes - A Global Challenge - Physiological Regulation of Blood Glucose Part 2 (16:52)

(View Complete Item Description)

This presentation provides an introduction to the islet hormones effects on various target tissues. Insulin is such a hormone, and in continuation of this, we’ll talk about the insulin receptor signaling. Furthermore we’ll talk about liver cells, fat cells, Lipogenesis, Insulin dose-response curves, C-peptide, Glucagon and glucagon producing tumor. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Jens Juul Holst

Diabetes - A Global Challenge - Physiological Regulation of Blood Glucose Part 3 (09:47)

(View Complete Item Description)

This presentation focus' on glucose and insulin, and how these are integrated in the intact organism, in continuation of this we’ll talk about, insulin and glucagon secretion, hepatic glucose production and plasma glucose concentrations. The purpose of this is to get an understanding of what happens in the body when you have type 2 diabetes. Furthermore we’ll talk about the possibility of developing an glucagon receptor antagonist, regarding the therapy of diabetes. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Jens Juul Holst

Diabetes - A Global Challenge - Diabetes Theraphy - Incretins and Surgery Part 2 (09:49)

(View Complete Item Description)

In this presentation we’ll talk about the effects of GLP-1 (Glucagon Like Peptide 1), GLP-1 has important actions on gastrointestinal secretion and motility, and it acts to inhibit appetite and food intake. In continuation of the effects of GLP-1, we’ll talk about GLP-1, GIP, lipids, proteins, and dipeptidyl peptidase-4. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Jens Juul Holst

Diabetes - A Global Challenge - Diabetes Theraphy - Incretins and Surgery Part 3 (18:56)

(View Complete Item Description)

This presentation talks about intravenously GLP-1 infusion to patients with type 2 diabetes. The GLP-1 infusion is capable of restoring fasting glucose concentrations during the night time and can nearly normalize the meal-induced glucose excursions after meal ingestion. GLP-1 has many attractive actions regarding diabetes type 2 treatment, which is the theme of this presentation. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Jens Juul Holst

Diabetes - A Global Challenge - Clinical Manifestation of Diabetes and Treatment Part 1 (25:27)

(View Complete Item Description)

The aim of this presentation is to address different hot topics in our current understanding of aetiology as well as of the pathophysiology of Type 2 Diabetes. We’ll address how genetic as well as epi-genetic and non-genetic mechanisms may be involved in the complex mechanisms underlying type 2 diabetes. We’ll also introduce recent data suggesting that immature stem-cell functions are likely to play an important role for development of type 2 diabetes and its associated cardiometabolic disturbances. Finally we’ll address the current treatment options of disease with respect of both pharmacological and non-pharmacological treatment modalities. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Allan Vaag

Diabetes - A Global Challenge - Clinical Manifestation of Diabetes and Treatment Part 2 (11:32)

(View Complete Item Description)

This presentation address the multifactorial etiology of type 2 diabetes. The multifactorial etiology, can be divided into three major categories, primary predisposing factors, secondary precipitating factors, as well as tertiary accelerating factors. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Allan Vaag

Diabetes - A Global Challenge - Clinical Manifestation of Diabetes and Treatment Part 3 (22:44)

(View Complete Item Description)

The aim of this presentation is to address and understand the paradigm shifting consequences of the Thrifty Phenotype Hypothesis as a conceptual framework to understand the roots of type 2 diabetes. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Allan Vaag

Diabetes - A Global Challenge - The Relation Between Obesity and Diabetes (15:06)

(View Complete Item Description)

In this presentation we’ll take a closer look at the relation between obesity and diabetes. Although it may seem simple, there are various aspects that make the relation between obesity and diabetes, more complex than at first sight. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Thorkild Sørensen

Diabetes - A Global Challenge - The Role of Inflammation in Type 2 Diabetes (14:12)

(View Complete Item Description)

In this lecture we’ll discuss the role of inflammation in type 2 diabetes. In patients with type 2 diabetes, cardiovascular complications are of particular interest, as these are mainly responsible for the increase of mortality and obesity in diabetic patients compared with healthy subjects. In continuation of this and in order to understand why diabetes is an inflammatory disease, we’ll provide an introduction to the acute phase response. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Bente Klarlund Pedersen

Diabetes - The Essential Facts - Who has Diabetes ? (15:59)

(View Complete Item Description)

In this presentation you will learn about the evolution of diabetes and how it affects the world population. Diabetes is probably recognized as one of the biggest global health challenges in the 21st century. Figures from 2012 shows that diabetes caused the death of 1.5 million people and lead to an additional 2.2 million deaths caused by higher than optimal blood glucose, which increases the risk of cardiovascular and other diseases. The prevalence of diabetes is rising in all income groups, however over the past decade it has risen faster in low and middle income countries rather than in high income countries. Narrator: Richard Steed.

Material Type: Lecture

Authors: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen, Professor Jens Juul Holst, Professor Venkat Narayan, Senior Researcher Kristine Færch

Diabetes - The Essential Facts - Surgery, Drugs and Microchips (17:12)

(View Complete Item Description)

Many people exercise and take medicine in order to delay or treat type 2 diabetes. However in most cases these interventions in one’s lifestyle fails and the person regain weight and retain their increasing blood glucose levels. Controlling one’s appetite seems to be the key, which is one of the aspects we’ll discuss in this presentation. Furthermore we’ll discuss how gastric bypass surgery helps people with diabetes type 2 controlling their appetite and make their diabetes disappear. Finally we’ll discuss how hormones such as GLP-1 can help diabetics’ control their appetite, and lose weight. Narrator: Richard Steed.

Material Type: Lecture

Authors: Associate Professor Signe Sørensen Torekov, Dr Tricia Tan, MD Nicolai Wewer Albrechtsen, Professor Jens Juul Holst, Professor Steven Bloom

Diabetes - The Essential Facts - How to Fight the Global Epidemic (12:11)

(View Complete Item Description)

This presentation discuss how we can fight the global diabetes epidemic. According to WHO (2016) the incidence and impacts of diabetes can largely be prevented or reduced with an approach that incorporates evidence-based, affordable, cost-effective, population-wide and multi-sector intervention. So which interventions should we prioritize as the most efficient interventions to fight the global diabetes epidemic? Narrator: Richard Steed.

Material Type: Lecture

Authors: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen, Professor Arne Astrup, Professor Jens Juul Holst, Professor Juleen Zierath, Professor Venkat Narayan

Diabetes - The Essential Facts - Who is at Risk ? (22:17)

(View Complete Item Description)

This presentation talks about who is at risk of developing diabetes and how diabetes will affect the future generations. You will be introduced to how the global amount of people diagnosed with diabetes, according to the WHO and the IDF, will increase from just over 400 million to 600 million by 2030. Narrator: Richard Steed.

Material Type: Lecture

Authors: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen, Professor Ib Bygbjerg, Professor Jens Juul Holst, Professor Venkat Narayan

Diabetes - The Essential Facts - Can we Cure Diabetes ? (17:02)

(View Complete Item Description)

This presentation focus on the question: can we cure diabetes? By interviewing different experts we will estimate how possible it is that we will find a cure for diabetes in the future. One of the main arguments is that we already have a cure, which is eating right and exercise, but the big question is whether people are willing to take this cure? Narrator: Richard Steed.

Material Type: Lecture

Authors: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen, Professor Jens Juul Holst, Professor Juleen Zierath, Professor Torben Hansen

Diabetes - A Global Challenge - Treatment of Hyperglycaemia with T2D Patients Part 1 (14:15)

(View Complete Item Description)

This presentation discuss how to treat hyperglycaemia in patients with type 2 diabetes. The cornerstone in the treatment is weight loss and increased physical activity, but most patients need pharmacological treatment from the time of diagnosis in order to control hyperglycemia. Furthermore we’ll discuss the use of all diabetic agents in patient with type 2 diabetes and how it’s important that the anti diabetic treatment is individualized. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Sten Madsbad