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Diabetes - The Essential Facts - What Role Does Nutrition Play ? (15:25)

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This presentation focus on which role nutrition plays in developing diabetes and how obesity affects diabetes development. Obesity and weight gain dramatically increase the risk of developing type 2 diabetes. But it’s not only the total calorie intake and the BMI that counts, so does the distribution between fat, protein and carbohydrates, in other words the composition of nutritions. In continuation of this it will be discussed how a restricting intake of carbohydrates might be the way to reduce or even eliminate the use of medication in diabetes treatments. Narrator: Richard Steed.

Material Type: Lecture

Authors: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen, Professor Arne Astrup, Professor Jens Juul Holst, Professor Venkat Narayan

Diabetes - The Essential Facts - What is Diabetes ? (13:45)

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This presentation provides an introduction to Diabetes.What is diabetes and what happens in the body? You will learn how diabetes is a term used to describe the body’s inability to produce sufficient amounts of insulin and how insulin as a pancreatic hormone functions as a main glucose regulator, that makes sure our glucose levels are balanced. Both high and low blood glucose levels are dangerous. When you have diabetes, the lack of insulin will cause high blood glucose levels, which affects several parts of your body. Narrator: Richard Steed.

Material Type: Lecture

Authors: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen, Professor Jens Juul Holst, Professor Steven Bloom

Diabetes - The Essential Facts - What Role Does Exercise Play ? (24:17)

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This presentation talks about which role exercise plays in developing diabetes. We will describe what happens in the body when we exercise, and why these changes help us prevent and treat diabetes. In continuation of this we’ll talk about the interaction between insulin, glucose and muscle cells and how we through exercise, can change our health. Furthermore we’ll discuss how lifestyle can affect one’s future children in terms of developing diabetes later on. Narrator: Richard Steed.

Material Type: Lecture

Authors: Associate Professor Dirk Lund Christensen, Associate Professor Signe Sørensen Torekov, MD Ida Donkin, MD Nicolai Wewer Albrechtsen, Professor Jens Juul Holst, Professor Juleen Zierath

Diabetes - A Global Challenge - Treatment of Hyperglycaemia with T2D Patients Part 2 (08:25)

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This presentation discuss the new antidiabetic agents. We have the incretin based therapy which include two groups of drugs, DDP-4 inhibitors and GLP-1 receptor agonist. Furthermore we’ll provide an introduction to the hormones GLP-1 and GIP and their effect on insulin. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Sten Madsbad

Diabetes - A Global Challenge - Inflammatory Beta-cell Destruction in Diabetes Part 1 (08:34)

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This presentations discuss diabetes as an disease of the pancreatic beta cell, in continuation of this, we’ll discuss what causes beta cell failure in type 1 and type 2 diabetes. Furthermore we’ll discuss the innate immune system and the beta cell failure, and inflammatory mediators as therapeutic targets of type 1 and type 2 diabetes. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Thomas Mandrup-Poulsen

Diabetes - A Global Challenge - Genetic Aspects of Non-autoimmune Diabetes Part 1 (06:40)

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This presentation provides an introduction to the genetic aspects of non-autoimmune diabetes. First we’ll introduce the genetic basis of diabetes, then we’ll talk about methods to identify genetic loci associated with diabetes and pre-diabetic traits. In continuation of this, we’ll provide examples of monogenic forms of diabetes and finally we’ll discuss common forms of non-autoimmune diabetes. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Torben Hansen

Diabetes - A Global Challenge - Genetic Aspects of Non-autoimmune Diabetes Part 2 (08:10)

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This presentation provides an introduction to methods used to identify genetic loci affecting diabetes and pre-diabetes traits. Furthermore we’ll discuss aspects that are important when choosing and considering different methods. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Torben Hansen

Diabetes - A Global Challenge - Genetic Aspects of Non-autoimmune Diabetes Part 4 (20:39)

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This presentation provides an introduction to the genetics behind the common forms of type 2 diabetes. Furthermore we’ll provide an introduction to the Genome-Wide Association Study, this study is a hypothesis generating method that contains a discovery and a replication sample. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Torben Hansen

Diabetes - A Global Challenge - Translational Metabolism Part 1 (12:56)

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In this presentation we’ll translate our knowledge from genetics into clinically relevant patient stories. We’ll present case stories of translational metabolism, which means that we go from genotype to phenotype. Translational science is a multidisciplinary form of science that bridges the gap between basic science and applied science. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Assistant Professor Signe Torekov

Diabetes - A Global Challenge - Translational Metabolism Part 2 (07:10)

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In this presentation aim to increase the student’s knowledge about translational metabolism, in continuation of this we’ll elaborate on topics related to food ingestion, bone resorption, the intestinale hormone GIP, genetic variation in the receptor of GIP in relation to fracture risk, food availability and bone regulation, blood glucose and future treatment of osteoporosis. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Associate Professor Signe Sørensen Torekov

Diabetes - A Global Challenge - Stem Cell Based Therapy of Diabetes Part 1 (13:24)

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This presentation provides an introduction to diabetes (Type 1 and Type 2) development and how it’s a significant global burden. We’ll also discusses how stem cell based therapy can be used to treat diabetes and which advantages and disadvantages this treatments provides. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Ole Dragsbæk Madsen

Diabetes - A Global Challenge - Stem Cell Based Therapy of Diabetes Part 2 (09:29)

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This presentation provides an introduction to The Edmonton Protocol, which was published back in year 2000 from University of Edmonton. In continuation of this, we’ll talk about insulin injections and hypoglycemia. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Ole Dragsbæk Madsen

Diabetes - A Global Challenge - Muscle as an Endocrine Organ - Role in Diabetes (13:08)

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The aim of this lecture is to give the student a new perspective on the muscle, the largest organ in the body. Skeletal muscles are primary identified by the mechanical activity required for posture, movement and breathing, which depends on muscle fiber contractions. However skeletal muscle isn’t just a component in our locomotor system. Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Material Type: Lecture

Author: Professor Bente Klarlund Pedersen

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