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Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students (2021) is an undergraduate medical-level resource for foundational knowledge across the disciplines of genetics, cell biology and biochemistry. This USMLE-aligned text is designed for a first-year undergraduate medical course that is delivered typically before students start to explore systems physiology and pathophysiology. The text is meant to provide the essential information from these content areas in a concise format that would allow learner preparation to engage in an active classroom. Clinical correlates and additional application of content is intended to be provided in the classroom experience. The text assumes that the students will have completed medical school prerequisites (including the MCAT) in which they will have been introduced to the most fundamental concepts of biology and chemistry that are essential to understand the content presented here. This resource should be assistive to the learner later in medical school and for exam preparation given the material is presented in a succinct manner, with a focus on high-yield concepts.

The 276-page text was created specifically for use by pre-clinical students at Virginia Tech Carilion School of Medicine and was based on faculty experience and peer review to guide development and hone important topics.

Available Formats
978-1-949373-42-4 (PDF)
978-1-949373-43-1 (ePub) [coming soon]
978-1-949373-41-7 (Pressbooks) https://pressbooks.lib.vt.edu/cellbio
Also available via LibreTexts: https://med.libretexts.org/@go/page/37584

How to Adopt this Book
Instructors reviewing, adopting, or adapting parts or the whole of the text are requested to register their interest at: https://bit.ly/interest-preclinical.

Instructors and subject matter experts interested in and sharing their original course materials relevant to pre-clinical education are requested to join the instructor portal at https://www.oercommons.org/groups/pre-clinical-resources/10133.

Features of this Book
1. Detailed learning objectives are provided at the beginning of each subsection
2. High resolution, color contrasting figures illustrate concepts, relationships, and processes throughout
3. Summary tables display detailed information
4. End of chapter lists provide additional sources of information
5. Accessibility features including structured heads and alternative-text provide access for readers accessing the work via a screen-reader

Table of Contents
1. Biochemistry basics
2. Basic laboratory measurements
3. Fed and fasted state
4. Fuel for now
5. Fuel for later
6. Lipoprotein metabolism and cholesterol synthesis
7. Pentose phosphate pathway (PPP), purine and pyrimidine metabolism
8. Amino acid metabolism and heritable disorders of degradation
9. Disorders of monosaccharide metabolism and other metabolic conditions
10. Genes, genomes, and DNA
11. Transcription and translation
12. Gene regulation and the cell cycle
13. Human genetics
14. Linkage studies, pedigrees, and population genetics
15. Cellular signaling
16. Plasma membrane
17. Cytoplasmic membranes
18. Cytoskeleton
19. Extracellular matrix

Suggested Citation
LeClair, Renée J., (2021). Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students, Blacksburg, VA: Virginia Tech Publishing. https://doi.org/10.21061/cellbio. Licensed with CC BY NC-SA 4.0.

About the Author
Renée J. LeClair is an Associate Professor in the Department of Basic Science Education at the Virginia Tech Carilion School of Medicine, where her role is to engage activities that support the departmental mission of developing an integrated medical experience using evidence-based delivery grounded in the science of learning. She received a Ph.D. at Rice University and completed a postdoctoral fellowship at the Maine Medical Center Research Institute in vascular biology. She became involved in medical education, curricular renovation, and implementation of innovative teaching methods during her first faculty appointment, at the University of New England, College of Osteopathic Medicine. In 2013, she moved to a new medical school, University of South Carolina, School of Medicine, Greenville. The opportunities afforded by joining a new program and serving as the Chair of the Curriculum committee provided a blank slate for creative curricular development and close involvement with the accreditation process. During her tenure she developed and directed a team-taught student-centered undergraduate medical course that integrated the scientific and clinical sciences to assess all six-core competencies of medical education.

Accessibility Note
The University Libraries at Virginia Tech and Virginia Tech Publishing are committed to making its publications accessible in accordance with the Americans with Disabilities Act of 1990. The HTML (Pressbooks) and ePub versions of this book utilize header structures and include alternative text which allow for machine-readability.

Please report any errors at https://bit.ly/feedback-preclinical

A grasp of the logic and practice of science is essential to understand the rest of the world around us. To that end, the CMB3e iText (like earlier editions) remains focused on experimental support for what we know about cell and molecular biology, and on showing students the relationship of cell structure and function. Rather than trying to be a comprehensive reference book, CMB3e selectively details investigative questions, methods and experiments that lead to our understanding of cell biology. This focus is nowhere more obvious than in the chapter learning objectives and in external links to supplementary material. In the freely available Basic CMB3e, the latter include the author’s short just-in-time YouTube VOPs, embedded near relevant text.

Like most introductory science textbooks, this one opens with a discussion of scientific method. A key feature is its focus on experimental support for what we know about cell and molecular biology. Understanding how science is practiced and how investigators think about experimental results is essential to understanding the relationship of cell structure and function…, not to mention our relationship to the natural world. This is a free Open Education Resource (OER), covered by a Creative Commons CCBY license (check out the Preface!). Every chapter begins with learning objectives and links to relevant recorded lectures. As used by the author, the iText engages students with embedded “just-in-time” learning tools. These include instructor’s annotations (comments) directing students to animations or text of interest, as well as links to writing assignments and quizzes. These interactive features aim to strengthen critical thinking and writing skills necessary to understand cell and molecular biology, not to mention science as a way of thinking in general. Please excuse the marketing terms, but you can choose between Bronze, Silver, or Gold versions, reflecting increasing potential for student interaction with the iText. Download your choice of the iText or the sample chapter at one of the links below.

This textbook was written for collegiate Cell and Molecular Biology courses and may be appropriate at both an introductory level and also as a resource for more advanced courses.

Anatomy and Physiology students must know the basics of cellular metabolism. This is an introduction to cellular metabolism.

Lesson 1 in our Cellular Metabolism For Anatomy and Physiology series. This is part of our Anatomy and Physiology lecture series.

If this video helps you please be sure to LST -like subscribe and tell your friends. Your support help us make more videos. For the complete series please visit http://mrfordsclass.net/

Videos in cell biology series:
- Introduction (04:01): http://youtu.be/efzWdP-i3Jo
- Respiration Fundamentals (04:02): http://youtu.be/5BIVqFptifc

The Central Nervous System (CNS) is composed of the brain and the spinal cord. This page is specifically focussed on the histologic appearance, for anatomy see Forebrain, Midbrain, Hindbrain, Cranial Nerves, Spinal Cord and CNS Development.

Traditionally, international business textbooks have relied on academic theory to educate students. We’re offering a new novel approach—a blend of the academic and the practitioner. The overarching logic of the book is intuitive—organized around answers to the what, where, why, and how of international business.

Chansons françaises is the integrated music component of Français interactif. Chansons features a French or Francophone song, related to each chapter's cultural or pedagogical focus, presented via audio or video. Accompanying pdfs provide additional information, as well as comprehension exercises. Songs act as a portal to various Francophone cultures and musical genres. Aural comprehension and study of lyrics afford students practice with culturally authentic text and expression. Students discover yet another reason to be passionate about studying French!

Short Description:
Proteins play vital roles in most biological processes; these roles include acting as catalysts for physiological reactions, as regulators for those reactions, or as structural framework around which these processes can occur. Proteins’ complex organization of diverse functionality in 3D space leads to an astonishing range of function for living organisms. Understanding this intimate relationship between structure and function is the backbone of understanding the natural world and is the key to controlling it. Data dashboard

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Spreadsheets Across Curriculum module. Students build spreadsheets to compare the time course of a reaction that goes to completion to that of an equilibrium reaction.

We help students see the connection between college level chemistry course work and their differential equations coursework. We do this through modeling kinetics, or rates of chemical reaction. We offer many opportunities to model these chemical reactions with data, some of which comes from traditional introductory chemistry textbooks. We ask students to verify their model through parameter estimation. We use Excel’s Trendline addition to graphs/charts to select the models for the data and transformed data to take advantage of Trendline’s set function choices and we also use Mathematica’s direct nonlinear fitting capabilities.

We are now going to delve into the heart of chemistry. We learn ways of representing molecules and how molecules react. To do this, we'll even think about "how many" of a molecule we have using a quantity called a "mole".

Chemistry is designed to meet the scope and sequence requirements of the two-semester general chemistry course. The textbook provides an important opportunity for students to learn the core concepts of chemistry and understand how those concepts apply to their lives and the world around them. The book also includes a number of innovative features, including interactive exercises and real-world applications, designed to enhance student learning.

Chemistry: Atoms First is a peer-reviewed, openly licensed introductory textbook produced through a collaborative publishing partnership between OpenStax and the University of Connecticut and UConn Undergraduate Student Government Association.

This title is an adaptation of the OpenStax Chemistry text and covers scope and sequence requirements of the two-semester general chemistry course. Reordered to fit an atoms first approach, this title introduces atomic and molecular structure much earlier than the traditional approach, delaying the introduction of more abstract material so students have time to acclimate to the study of chemistry. Chemistry: Atoms First also provides a basis for understanding the application of quantitative principles to the chemistry that underlies the entire course.

Chemistry is all around us "from the air we breathe to the food we eat" to the items at the supermarket that say “no chemicals added”. In fact, it is impossible to create something without using chemistry because chemistry consists of all matter. It allows us to answer questions as simple as why a candle goes out when a glass is placed over it to more complex questions such as does a candle actually burn in zero gravity? Chemistry is the study of matter and the changes it undergoes such as ice changing from the solid to liquid to gas phase. People have used it for things such as creating metal from an ore, dying fabric and making cheese. Chemistry deals with different substances and how they can interact with each other to create a product.

As you begin your study of college chemistry, those of you who do not intend to become professional chemists may well wonder why you need to study chemistry. You will soon discover that a basic understanding of chemistry is useful in a wide range of disciplines and career paths. You will also discover that an understanding of chemistry helps you make informed decisions about many issues that affect you, your community, and your world. A major goal of this text is to demonstrate the importance of chemistry in your daily life and in our collective understanding of both the physical world we occupy and the biological realm of which we are apart.

People around the world are fascinated about the preparation of food for eating. There are countless cooking books, TV shows, celebrity chefs and kitchen gadgets that make cooking an enjoyable activity for everyone. The chemistry of cooking course seeks to understand the science behind our most popular meals by studying the behavior of atoms and molecules present in food. This book is intended to give students a basic understanding of the chemistry involved in cooking such as caramelization, Maillard reaction, acid-base reactions, catalysis, and fermentation. Students will be able to use chemistry language to describe the process of cooking, apply chemistry knowledge to solve questions related to food, and ultimately create their own recipes.

A workbook designed by Nemours, to be used by child care providers, families and communities as a reference to tool to raise fit, happy children.

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Over the years researchers have found the necessity to develop theories of behavior that are specific to family settings. These theories have been developed by people with a variety of areas of emphasis, from family therapists to gerontologists to child development specialists. In this chapter we will briefly discuss six such theories: Bioecological Model, Family Systems, Functionalism, Conflict Theory, Symbolic Interactionism, and Psychological Perspectives.