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Amping up the AMPK/SR-A1 pathway can reduce chemo-induced nerve pain
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Many patients undergoing chemotherapy for cancer develop a serious side effect called chemotherapy-induced peripheral neuropathy (CIPN). CIPN involves pain, tingling, burning, or numbness in the hands and feet and is caused by neuroinflammation triggered by the protein HMGB1, but the exact mechanisms aren’t clear. To learn more and help find a treatment, researchers recently examined the plasma of human patients and mice with oxaliplatin-induced CIPN. They found that the levels of HMGB1 and its target enzyme MMP-9 (a pain marker) were elevated in CIPN plasma and that a higher dose of oxaliplatin was associated with higher HMGB1 levels and worse pain. In cell experiments, HMGB1 was degraded—and inflammatory molecule expression was suppressed—when the enzyme AMPK was activated suggesting that AMPK activation might be beneficial for CIPN. These effects were dependent on the protein SR-A1..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/08/2023
Amy Coney Barrett
Read the Fine Print
Educational Use
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In October 2020, Amy Coney Barrett became the fifth woman confirmed to the U.S. Supreme Court.

This resource is from a collection of biographies of famous women. It is provided by the National Women's History Museum, and may include links to supplemental materials including lesson plans about the subject and related topics, links to related biographies, and "works cited" pages. The biographies are sponsored by Susan D. Whiting.

Subject:
Gender and Sexuality Studies
History
Social Science
Material Type:
Reading
Provider:
National Women's History Museum
Provider Set:
Biographies
Author:
National Women's History Museum
Date Added:
03/01/2023
Ana Laura por um mundo sustentável
Unrestricted Use
Public Domain
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A Cartilha Eletrônica de Educação Ambiental sobre Resíduos Sólidos “ANA LAURA POR UM MUNDO SUSTENTÁVEL”de autoria de Elane Alvarenga Oliveira Hora e Rosana de Oliveira Santos Batista, trata-se de um Produto Técnico Educacional apresentado ao Programa de Pós-Graduação em Rede Nacional para o Ensino das Ciências Ambientais - PROFCIAMB, Universidade Federal de Sergipe - UFS, para atender aos requisitos do Mestrado Profissional para a obtenção do título de Mestre em Ciências Ambientais. A cartilha é um importante instrumento de referência de Educação Ambiental, pois esse material didático de divulgação será utilizado para dar apoio e também sensibilizar os gestores ambientais municipais, coordenadores e equipe das Novas Salas Verdes, assim como, de seu público alvo, ou seja, alunos da Educação Básica, a comunidade em geral e demais municípios sergipanos sobre os impactos e problemáticas socioambientais relacionadas à temática de resíduos sólidos em Sergipe, em conformidade com a Política Nacional de Resíduos Sólidos Lei 12.305/2010 (BRASIL, 2010).

Subject:
Applied Science
Education
Environmental Science
Material Type:
Reading
Author:
Rosana de Oliveira Santos Batista
Elane Alvarenga Oliveira Hora
Date Added:
06/03/2020
Ana Roqué de Duprey
Read the Fine Print
Educational Use
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Ana Roqué de Duprey, a prolific educator, writer, and scientist, founded the first woman’s suffrage organization in Puerto Rico in 1917.

This resource is from a collection of biographies of famous women. It is provided by the National Women's History Museum, and may include links to supplemental materials including lesson plans about the subject and related topics, links to related biographies, and "works cited" pages. The biographies are sponsored by Susan D. Whiting.

Subject:
Gender and Sexuality Studies
History
Social Science
Material Type:
Reading
Provider:
National Women's History Museum
Provider Set:
Biographies
Author:
National Women's History Museum
Date Added:
03/01/2023
Anaesthesia and Surgery - Small Mammals
Only Sharing Permitted
CC BY-NC-ND
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Because small mammals are prey species, they do not take to intensive conditions of surgery and hospitalisation very readily. Those that are handled very frequently by their owners are more bonded with humans and better surgical subjects as a result. Rodents and rabbits are particularly susceptible to the surgical complications of dehydration (blood and fluid loss), core temperature depression, hypovolaemic shock, ileus and renal and respiratory depression.

Subject:
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Anasthesia
Date Added:
02/27/2015
Analog vs. Digital Waves
Unrestricted Use
CC BY
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This lesson follows the NGSS standards for reviewing analog and digital waves. Students will be able to review the differences and similarities of analog and digital waves. Students will also be able to review how signals sent as analog or digital waves are used. 

Subject:
Physical Science
Material Type:
Homework/Assignment
Lesson
Reading
Author:
John Newman
Date Added:
12/22/2019
Analog vs. Digital Waves
Unrestricted Use
CC BY
Rating
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This lesson follows the NGSS standards for reviewing analog and digital waves. Students will be able to review the differences and similarities of analog and digital waves. Students will also be able to review how signals sent as analog or digital waves are used. 

Subject:
Physical Science
Material Type:
Lesson
Reading
Author:
John Newman
Date Added:
12/24/2019