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"Bariatric surgeries like gastric bypass are often used for weight loss, but they can also help protect patients from fatal heart attacks, possibly by altering the levels of gut-derived metabolic hormones like GLP-1, leptin, ghrelin, and insulin, which are known to affect heart tissue, or by acting on heart tissue directly. Researchers recently investigated the mechanisms by performing three common bariatric surgeries on non-obese, non-diabetic rats. Ten weeks later, the researchers subjected the rats to simulated heart attacks by restricting and reestablishing their cardiac blood flow. Both Roux-en-Y gastric bypass and sleeve gastrectomy, but not ileal transposition surgery, reduced the size of the damaged area in the heart and the no-reflow area to which blood flow couldn’t be restored. Gastric bypass and sleeve gastrectomy also increased GLP-1 and leptin levels, while sleeve gastrectomy reduced ghrelin levels. In contrast, none of the surgeries affected insulin levels..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.