This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Uncovering the links between microbiome profiles and host conditions is critical to understanding the roles microbes play in human health. However, analysis of microbiome profiles with traditional testing frameworks is made difficult by the high-dimensionality and sparsity of the data. Often this is addressed by incorporating information from closely related microbes. This phylogenetic information is added under the assumption that operational taxonomic units (OTUs) from related taxa will tend to behave similarly, but the complexity of microbe interactions can make this assumption invalid. The recently developed tool, Phylogeny-guided microbiome OTU-Specific association Test (POST), addresses this issue. POST determines how much, if any, information to borrow from neighboring OTUs based on phylogenetic distance and outcome-OTU association. This tool is a local collapsing test built under the kernel machine framework to accommodate complex OTU effects..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
In this lab, students will discuss their own concerns and ask for advice from their classmates. They will also read a social media post that discuss someone's worries and think about strategies that could help the person.