UniProt is a high quality, comprehensive protein resource. Next to expert curation, one of the core activities at UniProt is to develop computational methods for the functional annotation of protein sequences. In this webinar, we will be introducing our functional annotation system UniFire that can be used by the community to share and run rule-based automatic annotation systems to add functional information to proteins.

Who is this course for?
No prior knowledge of bioinformatics is required, but an undergraduate level knowledge of biology would be useful.

Outcomes
By the end of the webinar you will be able to:

Outline the types of data available in UniProt
Describe the automatic annotation systems used in UniProt
Describe the UniFire platform for sharing and utilising UniProt’s automatic annotation systems

The Ensembl VEP is a powerful tool that allows you to input a list of genetic variants and determines which genes are affected and how. In this webinar, you’ll learn how to use the online VEP tool, which is suitable for analysing short lists of genetic variants, and the offline tool, which allows you to annotate whole genome variant calls.

Who is this course for?
This webinar is suitable to any clinical or research scientists who are interested in exploring genetic variants and their effect. In this webinar we will use examples from human clinical data but the VEP tool is available for other species too.

Outcomes
By the end of the webinar you will be able to:

Describe the application of VEP
Analyse short lists of genetic variants using VEP
Annotate variation data

This series of visualizations show the annual Arctic sea ice minimum from 1979 to 2015. The decrease in Arctic sea ice over time is shown in an animation and a graph plotted simultaneously, but can be parsed so that the change in sea ice area can be shown without the graph.

The annual percentage rate (APR) that you are charged on a loan may not be the amount of interest you actually pay. The amount of interest you effectively pay is greater the more frequently the interest is compounded. In this video, we calculate the effective APR based on compounding the APR daily. Created by Sal Khan.

Poster showing a soldier blowing a bugle. Poster no. 21. W. 8.790/174. 25M. 12/14. Title from item.

Poster showing a Marine carving a notch in the stock of his rifle. Title from item.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A recent study published in Acta Neuropathologica Communications has found a potential mechanism for the initiation and development of Parkinson’s disease and it appears red blood cells may be partly to blame. Parkinson’s is a chronic and progressive neurodegenerative disorder commonly associated with tremors, muscle stiffness, and impaired movement. While these symptoms are caused by the deterioration of nerve cells in the brain, the precise cause of the disease is still not fully understood. What is known is that the development of Parkinson’s is associated with the aggregation of toxic forms of a protein named alpha-synuclein (or alpha-syn, for short) in the brain. Recent evidence, however, suggests alpha-syn found in the blood can also be problematic and this has been implicated as a contributor to brain-cell breakdown..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In 1943, Ansel Adams (1902-1984), America's best-known photographer, documented the Manzanar War Relocation Center in California and the Japanese Americans interned there during World War II. The collection presents for the first time side-by-side digital scans of both Adams's 242 original negatives and his 209 photographic prints, allowing viewers to see his darkroom technique and in particular how he cropped his prints. Adams's Manzanar work is a departure from his signature style of landscape photography. Although a majority of the photographs are portraits, the images also include views of daily life, agricultural scenes, and sports and leisure activities.