Limiting the debilitating consequences of ageing is a major medical challenge of our time. Robust pharmacological interventions that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathways. Here we report results from the Caenorhabditis Intervention Testing Program in assessing longevity variation across 22 Caenorhabditis strains spanning 3 species, using multiple replicates collected across three independent laboratories. Reproducibility between test sites is high, whereas individual trial reproducibility is relatively low. Of ten pro-longevity chemicals tested, six significantly extend lifespan in at least one strain. Three reported dietary restriction mimetics are mainly effective across C. elegans strains, indicating species and strain-specific responses. In contrast, the amyloid dye ThioflavinT is both potent and robust across the strains. Our results highlight promising pharmacological leads and demonstrate the importance of assessing lifespans of discrete cohorts across repeat studies to capture biological variation in the search for reproducible ageing interventions.

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Introducción al español comercial

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There seems to be little resistance to the idea that children and teens learn in public library spaces. However, many public librarians do not see themselves as teachers. This implies that much of the learning that happens in public libraries is incidental—tangential to the “real” purpose and design of these spaces and programs.

In this book, we make the case that public librarians should embrace an explicit instructional role as a core part of their professional practice. Inside, you’ll find both a comprehensive review of what is known so far about instruction for youth in public libraries and a primer on core educational concepts and frameworks for current and future public librarians. Each chapter includes real-world examples of libraries and librarians who are already practicing powerful teaching.

We hope that this text will inspire a new group of students, practitioners, and researchers to expand on our ideas, create innovative forms of teaching and learning that are unique to public libraries, and engage all children and teens in powerful and meaningful learning experiences.

This course is a study of the history of theater art and practice from its origins to the modern period, including its roles in non-western cultures. Special attention is given to the relationship between the literary and performative dimensions of drama, and the relationship between drama and its cultural context.

An introductory course on teaching and learning science and mathematics in a variety of K-12 settings. Topics include education and media, education reform, the history of education, simulations, games, and the digital divide.

Data Carpentry lesson to understand data structures and common storage and transfer formats for spatial data. The goal of this lesson is to provide an introduction to core geospatial data concepts. It is intended for learners who have no prior experience working with geospatial data, and as a pre-requisite for the R for Raster and Vector Data lesson . This lesson can be taught in approximately 75 minutes and covers the following topics: Introduction to raster and vector data format and attributes Examples of data types commonly stored in raster vs vector format Introduction to categorical vs continuous raster data and multi-layer rasters Introduction to the file types and R packages used in the remainder of this workshop Introduction to coordinate reference systems and the PROJ4 format Overview of commonly used programs and applications for working with geospatial data The Introduction to R for Geospatial Data lesson provides an introduction to the R programming language while the R for Raster and Vector Data lesson provides a more in-depth introduction to visualization (focusing on geospatial data), and working with data structures unique to geospatial data. The R for Raster and Vector Data lesson assumes that learners are already familiar with both geospatial data concepts and the core concepts of the R language.

Data Carpentry lesson to open, work with, and plot vector and raster-format spatial data in R. The episodes in this lesson cover how to open, work with, and plot vector and raster-format spatial data in R. Additional topics include working with spatial metadata (extent and coordinate reference systems), reprojecting spatial data, and working with raster time series data.

Pneumonia still kills almost a million children each year, making it the biggest child killer. Most of its victims are less than 2 years old. Learn more about pneumonia and how to prevent it here.
Get transcript for video here: https://www.oercommons.org/courseware/module/58789/overview

Diarrheal diseases are easy to prevent, but is still one of the biggest child killers. In the past few years there has been a reduction in diarrheal deaths, in part thanks to the new Rota vaccine.
Get transcript for video here: https://www.oercommons.org/courseware/module/58789/overview

Even though malaria cases have gone down in the past 20 years, the battle is still not won, and in some places there's a backlash. There is also the threat of drug resistance that can revert this positive trend. Learn more about our third biggest child killer - malaria.
Get transcript for video here: https://www.oercommons.org/courseware/module/58789/overview

Vaccination is one of the main successes in public health. Learn more about common childhood vaccinations, both old and new.
Get transcript for video here: https://www.oercommons.org/courseware/module/58789/overview

The goal of this lesson is to provide an introduction to R for learners working with geospatial data. It is intended as a pre-requisite for the R for Raster and Vector Data lesson for learners who have no prior experience using R. This lesson can be taught in approximately 4 hours and covers the following topics: Working with R in the RStudio GUI Project management and file organization Importing data into R Introduction to R’s core data types and data structures Manipulation of data frames (tabular data) in R Introduction to visualization Writing data to a file The the R for Raster and Vector Data lesson provides a more in-depth introduction to visualization (focusing on geospatial data), and working with data structures unique to geospatial data.

In this activity, students are introduced to the methods of inquiry in the Earth sciences and how they differ from what is classically taught in school science.

In this field activity students will discover some of the factors that influence weathering of rock by making observations, asking questions and completing an investigation of their own design in a local cemetery.

This activity is a field investigation where students will be able to observe sinkholes located in the southeastern Minnesota area and a cave system in Forestville State Park which will assist them in defining Karst topography.

This set of activities is designed to help students develop an understanding of scale/distance and ordering the planets from the sun, understanding Earth's position in the solar system, and developing new ways of determining "order."

Students will investigate how sounds are made and changed, record their findings in their journal, share these findings with the class, and develop further questions about sound.