This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Certain gut microbes and their metabolites contribute to the progression of benign colorectal adenoma (CRA) into colorectal cancer (CRC), but the specific microbes, metabolites, and mechanisms involved are unclear. To learn more, researchers recently analyzed stool samples from patients with CRA or CRC and normal control (NC) subjects. The levels of certain stool metabolites significantly differed among the groups. For example, myristic acid and norvaline became more abundant with progression from health to CRC. The CRC-associated metabolites were largely branched- chain amino acids and aromatic amino acids and were involved in aminoacyl-tRNA biosynthesis pathways. A metabolite “signature” distinguished CRC samples from NC samples and CRC samples from CRA samples and the relationships among CRC-related metabolites and gut bacteria differed in the different sample types..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

An interactive applet and associated web page that demonstrate the alternate exterior angles that are formed where a transversal crosses two lines. The applets shows the two possible pairs of angles alternating when in animation mode. By dragging the three lines, it can be seen that the angles are congruent only when the lines are parallel. When not in animated mode, there is a button that alternates the two pairs of angles. The text on the page discusses the properties of the angle pairs both in the parallel and non-parallel cases. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

An interactive applet and associated web page that demonstrate the alternate interior angles that are formed where a transversal crosses two lines. The applets shows the two possible pairs of angles alternating when in animation mode. By dragging the three lines, it can be seen that the angles are congruent only when the lines are parallel. When not in animated mode, there is a button that alternates the two pairs of angles. The text on the page discusses the properties of the angle pairs both in the parallel and non-parallel cases. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

This study used an organizational socialization lens to examine factors influencing participants’ choice to pursue the principalship and an alternate administration certification program. Through an analysis of participants’ interviews, factors emerged from the codes that were compared with dimensions of a socialization framework. A key finding from this study is the intersection of socializing factors that influenced participants’ decisions to pursue the principalship and their decision to pursue an alternative preparation programs. This intersection impacted how these aspiring and current principals came to participate in the alternate preparation program.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Autophagy is an important cellular recycling process that degrades misfolded proteins and damaged organelles. In typical (“canonical”) autophagy, membranes derived from the endoplasmic reticulum surround damaged materials that need to be degraded, and the proteins Atg5 and Atg7 help form specialized digestion compartments (autophagosomes), but another type of autophagy, called alternative autophagy, was recently discovered. In alternative autophagy, the membranes that envelop the damaged materials are derived from the trans-Golgi membrane, and Atg5 and Atg7 do not participate in autophagosome formation. Alternative autophagy seems to be activated primarily under conditions of cell stress, and it plays roles in many diseases, such as heart disease, neurodegenerative disease, cancer, inflammatory bowel disease, and bacterial infection..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The gut microbiome interacts intimately with its human host, both in health and in disease. A recent study examined how different states of the gut microbiome might be linked to varying degrees of disease in rats. Researchers exposed rats to different concentrations of dextran sodium sulfate (DSS), a polysaccharide known to induce human-like colitis. The effects on the intestinal microbiome over time were tracked by gene profiling. The results provide some of the first experimental evidence of “alternative states” in the rat intestinal ecosystem. These are distinct microbial profiles related to markers of disease. Importantly, these alternative states were found to be tied to both the host and microbiome, rather than one or the other. That led to a conceptual model of how host inflammatory status and microbiome status interact and how the whole ecosystem may slip into and out of different states of disease..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Since its appearance in late 2019, COVID-19 has caused well over one million deaths worldwide. Large-scale testing and contact tracing remain critical for controlling viral spread. Complying with the US CDC and WHO protocols for sample collection requires a ready supply of inexpensive swabs and collection reagents. Unfortunately, CDC-approved clinical-grade sampling supplies are expensive, and additionally, current methods prevent further analysis of the microbiome due to the presence of antibiotics in viral transport media. Researchers sought out new testing supplies in a recent study comparing five consumer-grade swabs and one clinical-grade swab. They found that using 95% ethanol instead of viral transfer media reduced RNase activity, preserving samples for microbiome analysis, and extracting directly from the swab head instead of the surrounding liquid resulted in 2-4x higher RNA recovery than the clinical standard..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is published by Altice USA. The Digital Smarts Blog resource is a weekly summary of articles related to digital safety including information on digital resources on media literacy, digital safety, misinformation, and other topics that parents and teachers need to stay abreast of. 

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"When patients undergo general anesthesia, there’s a shift in the distribution of ventilation and perfusion throughout the lung, with more areas of the lung getting too much air, relative to the amount of blood flow, and others getting too little. This type of scatter is traditionally described by Riley’s three-compartment model, in which high-ratio lung regions getting less blood flow produce increases in the alveolar deadspace. But new work published in the journal Anesthesiology shows that this model fails to account for different blood solubilities of various anesthetics -- and shows how multicompartment models better predict what is happening in the lungs. The researchers extended an earlier study in anesthetized patients that found that partial pressure measurements of inhaled anesthetic in the lungs did not match those made for carbon dioxide -- and were inconsistent with the three-compartment theory..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Glioma is the most common and lethal form of brain cancer. Among patients with the highest grade of glioma, fewer than 6% survive up to 5 years after diagnosis. Interestingly, glioma is extremely rare in one large population of patients patients with Alzheimer’s disease. That suggests that an anti-glioma molecule could play a critical role in the development of Alzheimer’s. In a recent study, researchers assessed one possible candidate: presenilin-1. Presenilin-1 is a protein that assists the formation of amyloid beta, the main component of the hallmark plaques found in the brains of patients with Alzheimer’s. Experiments showed that high presenilin-1 levels in glioma tissue from patients correlated with low tumor proliferation. Closer examination revealed that presenilin-1 kept cancer from spreading by preventing tumor cells from replicating their DNA. This mechanism could explain the poor prognosis of glioma patients with low levels of presenilin-1..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"There may be a silver lining for those at high risk for Alzheimer’s: as the chance of getting the disease goes up, certain treatments may become more effective. The risk of developing Alzheimer’s largely relies on a gene called APOE, with different variants conferring more or less risk. Usually, having a high-risk allele is bad news, but a group of researchers from New York University has reported that carrying the high-risk allele could actually boost responsiveness to immunotherapy, a promising new treatment option. The APOE gene helps determine how much beta-amyloid accumulates in the brain. Beta-amyloid starts as small misfolded bits of protein that clump together to form the plaques that are the hallmark of Alzheimer’s. As the plaques appear, the brain deteriorates, particularly in regions associated with memory. One way to potentially halt this process is to use antibodies that recognize beta-amyloid. The antibodies bind to the protein and signal to the immune system to clear it out..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Amanda Blackhorse has always seen Native American women fighting against injustice. Blackhorse, member of the Navajo, a social worker and mother of two, served as the named plaintiff in the 2006 lawsuit Blackhorse et al v. Pro-Football Inc.

This resource is from a collection of biographies of famous women. It is provided by the National Women's History Museum, and may include links to supplemental materials including lesson plans about the subject and related topics, links to related biographies, and "works cited" pages. The biographies are sponsored by Susan D. Whiting.