Anxiety is a natural part of life and, at normal levels, helps us to function at our best. However, for people with anxiety disorders, anxiety is overwhelming and hard to control. Anxiety disorders develop out of a blend of biological (genetic) and psychological factors that, when combined with stress, may lead to the development of ailments. Primary anxiety-related diagnoses include generalized anxiety disorder, panic disorder, specific phobia, social anxiety disorder (social phobia), post traumatic stress disorder, and obsessive-compulsive disorder. In this module, we summarize the main clinical features of each of these disorders and discuss their similarities and differences with everyday experiences of anxiety.

Using the context of apples, students will apply their knowledge of heredity and genetics to distinguish between sexual and asexual reproduction as they explain how new varieties of apples are developed and then propagated to meet consumer demand for a tasty, uniform, consistent product. Photo by Sokmean Nou on Unsplash

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Acute hepatopancreatic necrosis disease (AHPND) is an important bacterial disease of shrimp caused by some Vibrio species and has severe negative impacts on shrimp aquaculture globally. Antibiotics are commonly used prophylactically against such diseases but can cause bacterial antibiotic resistance and microbiome impairment. Given the risk of antibiotics to human and environmental health, the application of probiotics is a promising approach, but whether these probiotics affect the shrimp gut microbiome remains unknown. Recently, researchers examined how the shrimp gastrointestinal microbiota responded to the ILI strain, a Vibrio strain that also serves as an effective shrimp probiotic. The ILI strain was effective not only in preventing AHPND and promoting shrimp survival but also in maintaining a healthy gut microbiome..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

The eBook “Applications of Plant Pathology in Genebank Collections” was developed in part by USDA-ARS and by grant 2020-70003-30930 from the USDA-NIFA-Higher Education Challenge Grant Program. Additional chapters will be added to this eBook when they are available. This eBook contains chapters that can be accessed in any order. Click on “Contents” in the upper left corner and then expand “Main Body” to access chapter titles; scrolling may be necessary to view all chapter titles. Chapters can also be navigated by using arrows at the bottom of each page. Each chapter has text, video and/or interactive content on a single page.

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The current edition of the book may be downloaded from the Applied Bioinformatics site. Traffic analytics interactive report

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The primary learning objective of this textbook is to introduce the reader to the fundamental statistical methods and basic analytical procedures associated with processing data in regard to healthcare research. It is intended that by working through the applications and practice problems, readers should be able to understand and apply some of the methods for developing, implementing, and applying healthcare statistic principles in research.

Using the Hardy-Weinberg equation to calculate allele and genotype frequencies. Created by Sal Khan.

This video segment adapted from NOVA features a variety of scientific perspectives on the age old question, "Are we alone in the universe?" Animations make vivid the improbability that we could intercept a radio wave signaling extra terrestrial intelligence.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"It’s a feared moment for every scientist: the discovery that years of painstaking research has led to results that can't be repeated. Many think that poorly characterized antibodies have contributed to this reproducibility crisis more than any other laboratory tool. A new study published in Molecular Cell supports this hypothesis, at least in the context of chromatin immunoprecipitation. Although accurate ChIP interpretation depends on near-perfect antibody specificity, the report shows that many of these reagents are far less capable than their advertising suggests, which calls into question several widely accepted paradigms on genomic regulation. The study focused on histone post-translational modifications; specifically all three methylation states of lysine 4 on histone H3. Through ChIP experiments, H3K4 methylation has been strongly linked to transcriptional control..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Deep-sea hydrothermal vent ecosystems host an array of macrofauna, including many invertebrates. These animals adapt to the extreme conditions by forging endosymbiotic relationships with chemoautotrophic bacteria. Phages, viruses that infect prokaryotes, can fundamentally affect endosymbiotic bacteria, but their specific roles in deep-sea vent endosymbionts are not yet known. A recent study utilized metagenomics, transcriptomics, and proteomics to examine the endosymbiotic phages associated with the deep-sea vent snail Gigantopelta aegis. These phages infected methane- and sulfur-oxidizing bacteria, and there was evidence of both lysogenic and lytic lifecycles. The genomes also showed evidence of an arms race between bacteria and phages, with the bacteria encoding defense systems like CRISPR–Cas to break down phage DNA and the phages encoding their own anti-defense mechanisms. The phages also had horizontally acquired auxiliary metabolic genes, which could benefit replication..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Ernst Haeckel is a medical doctor, artist, philosopher, and naturalist of the late 1800s/early 1900s who beautifully and accurately depicted sea animal and plant life using color illustrations; you can find many examples of his sketches online through websites such as this one (Kuriositas, January 2012)and in his published works like Art Forms of Nature (1899). He promoted Darwin's theory of natural selection and created many words in the study of biology such as phylogeny and protist. I can see his work being used to inspire student observations, which are the basis of scientific discovery and study and as a supplement within specific units of biology including classification and evolution studies. I can also envision them being used during curriculum development within a professional development setting for teachers or a collaborative project integrating art and science instruction.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The tick-borne parasite Theileria annulata can cause life-threatening illness in cows. Buparvaquone is the only available drug treatment, but the incidence of buparvaquone (BPQ) resistance is increasing so alternative therapies are needed. To help, researchers recently tested the efficacy of the anti-malaria drug artemisinin and its derivatives against T. annulata infection. Artemisinin itself wasn’t effective, but all of its derivatives were able to selectively kill parasite-infected cells. Artesunate (ARS) and dihydroartemisinin (DHART) were especially potent and either drug could act synergistically with BPQ, enhancing the parasite-killing effects of the individual compounds. Investigation of the mechanism revealed that ARS and DHART caused oxidative stress and DNA damage in the infected cells which activated the protein p53 and the caspase-dependent cell death pathway..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This course introduces representations, techniques, and architectures used to build applied systems and to account for intelligence from a computational point of view. This course also explores applications of rule chaining, heuristic search, logic, constraint propagation, constrained search, and other problem-solving paradigms. In addition, it covers applications of decision trees, neural nets, SVMs and other learning paradigms.

This video segment explores the benefits and pitfalls of cloning as a means of reproduction. From Evolution: "Why Sex?"

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Microbial metagenomes are like a blueprint of all the functions performed by a microbial community. Some microbes can't be grown in the lab, so metagenomics is important for investigating otherwise-unknown microbial "dark matter". Short-read sequencing provides large amounts of data, but it's hard to assemble into complete genomes. A recent study combined short-read data with nanopore long-read data using Iterative Hybrid Assembly (IHA). The researchers reconstructed 49 metagenome-assembled genomes (MAGs), including some with very low coverage. In total, 34 MAGs did not belong to any known genus, representing unknown microbe groups. The IHA method revealed more of the genes present than a short-read-only approach and showed that the anammox genome of genus Ca. Brocadia contains two identical hydrazine synthase genes. The current method is best for enriched microbial communities and will be extended to high-complexity samples in the future..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Astronomy Notes is a website with a brief overview of astronomy's place in the scientific endeavor, the philosophy of science and the scientific method, astronomy that can be done without a telescope, a history of astronomy and science, Newton's law of gravity and applications to orbits, Einstein's Relativity theories, electromagnetic radiation, telescopes, all the objects of the solar system, solar system formation, determining properties of the stars, the Sun, fusion reactions, stellar structure, stellar evolution, the interstellar medium, the structure of the Milky Way galaxy, extra-galactic astronomy including active galaxies and quasars, cosmology, and extra-terrestrial life. This site also has pages giving angular momentum examples, a quick mathematics review, improving study skills, astronomy tables, and astronomy terms

This course provides a graduate-level introduction to stellar astrophysics. It covers a variety of topics, ranging from stellar structure and evolution to galactic dynamics and dark matter.