This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"The pumping action of the heart is tightly regulated by many factors. For example, the ion channel proteins RyR2 and SERCA2a regulate cardiac contraction via the β adrenergic receptor (βAR) pathway and under stress conditions, βAR stimulation promotes the enzyme activity of PKA to ultimately enhance cardiac contraction and relaxation. However, it’s unclear exactly how βAR-stimulated PKA dynamically affects RyR2 and SERCA2a within their nano-scale subcellular domains. To learn more, researchers recently used biosensors to detect PKA activity at these nanodomains in heart cells from mice, rats, and rabbits. They found that the βAR subtype β₁AR signaled to both RyR2 and SERCA2a nanodomains via PKA, while β₂AR did not. Specifically, β₂AR signaling at these nanodomains was prevented by the enzymes PDE3 and PDE4, which controlled baseline PKA activity, but blocking an inhibitory G protein permitted β₂AR signaling at the RyR2 nanodomains..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
PDE Science Advisor David Bauman unpacks the Foundation Boxes and explains how …
PDE Science Advisor David Bauman unpacks the Foundation Boxes and explains how they support Science, Technology & Engineering, and Environmental Literacy & Sustainability instruction and curriculum development. This introduction can set the stage for educators to begin unpacking STEELS standards.
Technology & Engineering (T&E) Advisor Brandt Hutzel unpacks the T&E Standards organization and structure. Brief vignettes illustrate the relationship of the standards to the strands, the related practices, and the contexts.
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