This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Calcium ions (Ca²⁺) are critical secondary messengers in our cells, shuttling messages from outside cells to within. Ca²⁺ signaling depends on transport proteins to move ions across membranes. Store-operated channels (SOCs) are one particularly important class of transporters for Ca²⁺ signaling. SOCs allow Ca²⁺ signaling to continue by refilling critical Ca²⁺ stores in a process called store-operated Ca²⁺ entry (SOCE). Our cardiovascular system is particularly dependent on Ca²⁺ signaling, even in non-excitable (i.g., non-muscle) cells like vascular endothelial cells. Growing evidence suggests that malfunctions in SOCs and the SOCE process contribute to many cardiovascular diseases. But the exact roles of SOCs and SOCE are not fully understood. A recent review examined the current literature on SOC function in the vasculature and what is currently known about SOCs' role in cardiovascular disease..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.