This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Traumatic brain injury (TBI), or brain damage caused by a sudden blow or jolt to the head, is a leading cause of death and disability worldwide. The mechanisms are complex and differ among patients, making TBI difficult to treat, and anti-inflammatory agents that are effective in animal models have been less promising in human trials, indicating that better treatments are needed. To explore new strategies, a recent study investigated the effect of the anti-inflammatory compound ACT001 on TBI. In mice, ACT001 reduced brain damage and improved motor function after TBI by reducing trauma-induced activation of microglia, which are immune cells of the central nervous system. In vitro, ACT001 also reduced activation of mouse and rat microglia induced by the bacterial toxin lipopolysaccharide (LPS) and downregulated LPS-induced secretion of proinflammatory molecules in a mouse microglial cell line..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Traumatic brain injury (TBI) is a leading cause of fatality and disability worldwide. Despite immense clinical efforts, treatments for TBI remain limited, and better understanding is needed. While most treatments have targeted neuronal cells, another cell type may also have an important role in TBI. Astrocytes, a subtype of brain-resident glial cells, help to control blood flow and maintain homeostasis in the central nervous system. These important cells have dual roles after TBI which must be better understood to improve treatment. During TBI, mechanical damage to neurons and blood vessels occurs instantly. This is followed by pathological processes - neuroinflammation and cell stress - mediated by astrocytes, among others. The astrocyte response is initiated to protect the central nervous system and promote wound healing but may become maladaptive over time as astrocytes can play bidirectional roles in plasticity and reconstruction after TBI..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Medicine has a big data problem. National healthcare registries provide invaluable data about patients and the reasons why they visit clinics and hospitals. Unfortunately, there’s so much of it, and relatively little has been done to organize it in a way that’s meaningful for understanding patient experiences. That makes probing by traditional research methods virtually impossible. How are researchers addressing this problem? One team has drawn inspiration from genomics. Using an algorithm routinely applied to study co-expression patterns of multiple genes, they’ve identified patterns in the circumstances surrounding people experiencing a traumatic brain injury. This approach could help clinicians spot markers of an impending injury before it happens. The team started with population-wide healthcare data spanning 9 year for residents of Ontario, Canada..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBI’s mechanism is complex, but it may involve a particular type of cell death called pyroptosis, especially among brain cells known as microglia. Mesenchymal stem cells (MSCs), such as the stem cells in umbilical cords, have recently been found to regulate pyroptosis, but it’s unclear whether transplanted MSCs could help alleviate pyroptosis after TBI. To find out, researchers recently administered human umbilical cord MSCs and the MSC-secreted protein TSG-6 into the brains of mice with induced TBI. Both the MSCs and the TSG-6 protein alleviated neurological deficits in the TBI mice. They also reduced inflammatory molecule expression and inhibited microglial pyroptosis in the cerebral cortex. The MSCs’ beneficial effects were weakened when TSG-6 expression was inhibited, confirming the importance of this molecule..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
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