Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students (2021) is an undergraduate medical-level resource for foundational knowledge across the disciplines of genetics, cell biology and biochemistry. This USMLE-aligned text is designed for a first-year undergraduate medical course that is delivered typically before students start to explore systems physiology and pathophysiology. The text is meant to provide the essential information from these content areas in a concise format that would allow learner preparation to engage in an active classroom. Clinical correlates and additional application of content is intended to be provided in the classroom experience. The text assumes that the students will have completed medical school prerequisites (including the MCAT) in which they will have been introduced to the most fundamental concepts of biology and chemistry that are essential to understand the content presented here. This resource should be assistive to the learner later in medical school and for exam preparation given the material is presented in a succinct manner, with a focus on high-yield concepts.

The 276-page text was created specifically for use by pre-clinical students at Virginia Tech Carilion School of Medicine and was based on faculty experience and peer review to guide development and hone important topics.

Available Formats
978-1-949373-42-4 (PDF)
978-1-949373-43-1 (ePub) [coming soon]
978-1-949373-41-7 (Pressbooks) https://pressbooks.lib.vt.edu/cellbio
Also available via LibreTexts: https://med.libretexts.org/@go/page/37584

How to Adopt this Book
Instructors reviewing, adopting, or adapting parts or the whole of the text are requested to register their interest at: https://bit.ly/interest-preclinical.

Instructors and subject matter experts interested in and sharing their original course materials relevant to pre-clinical education are requested to join the instructor portal at https://www.oercommons.org/groups/pre-clinical-resources/10133.

Features of this Book
1. Detailed learning objectives are provided at the beginning of each subsection
2. High resolution, color contrasting figures illustrate concepts, relationships, and processes throughout
3. Summary tables display detailed information
4. End of chapter lists provide additional sources of information
5. Accessibility features including structured heads and alternative-text provide access for readers accessing the work via a screen-reader

Table of Contents
1. Biochemistry basics
2. Basic laboratory measurements
3. Fed and fasted state
4. Fuel for now
5. Fuel for later
6. Lipoprotein metabolism and cholesterol synthesis
7. Pentose phosphate pathway (PPP), purine and pyrimidine metabolism
8. Amino acid metabolism and heritable disorders of degradation
9. Disorders of monosaccharide metabolism and other metabolic conditions
10. Genes, genomes, and DNA
11. Transcription and translation
12. Gene regulation and the cell cycle
13. Human genetics
14. Linkage studies, pedigrees, and population genetics
15. Cellular signaling
16. Plasma membrane
17. Cytoplasmic membranes
18. Cytoskeleton
19. Extracellular matrix

Suggested Citation
LeClair, Renée J., (2021). Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students, Blacksburg, VA: Virginia Tech Publishing. https://doi.org/10.21061/cellbio. Licensed with CC BY NC-SA 4.0.

About the Author
Renée J. LeClair is an Associate Professor in the Department of Basic Science Education at the Virginia Tech Carilion School of Medicine, where her role is to engage activities that support the departmental mission of developing an integrated medical experience using evidence-based delivery grounded in the science of learning. She received a Ph.D. at Rice University and completed a postdoctoral fellowship at the Maine Medical Center Research Institute in vascular biology. She became involved in medical education, curricular renovation, and implementation of innovative teaching methods during her first faculty appointment, at the University of New England, College of Osteopathic Medicine. In 2013, she moved to a new medical school, University of South Carolina, School of Medicine, Greenville. The opportunities afforded by joining a new program and serving as the Chair of the Curriculum committee provided a blank slate for creative curricular development and close involvement with the accreditation process. During her tenure she developed and directed a team-taught student-centered undergraduate medical course that integrated the scientific and clinical sciences to assess all six-core competencies of medical education.

Accessibility Note
The University Libraries at Virginia Tech and Virginia Tech Publishing are committed to making its publications accessible in accordance with the Americans with Disabilities Act of 1990. The HTML (Pressbooks) and ePub versions of this book utilize header structures and include alternative text which allow for machine-readability.

Please report any errors at https://bit.ly/feedback-preclinical

This textbook was written for collegiate Cell and Molecular Biology courses and may be appropriate at both an introductory level and also as a resource for more advanced courses.

In The Centrality of Style, editors Mike Duncan and Star Medzerian Vanguri argue that style is a central concern of composition studies even as they demonstrate that some of the most compelling work in the area has emerged from the margins of the field. Calling attention to this paradox in his foreword to the collection, Paul Butler observes, "Many of the chapters work within the liminal space in which style serves as both a centralizing and decentralizing force in rhetoric and composition. Clearly, the authors and editors have made an invaluable contribution in their collection by exposing the paradoxical nature of a canon that continues to play a vital role in our disciplinary history."

The Changing Story gives you assignments, resources, and examples to use in your teaching and learning. It will also help you think of ways digital stories can be used in your teaching, and help students harness the power of visual storytelling.

Chapeau! is a first-year college text. Although it may appear, at first glance, to move very fast and introduce a large amount of material early, the vocabulary and grammatical structures that we expect students to control actively by the end of the year are limited in accord with our notion of a reasonable application of the ACTFL proficiency guidelines. As a result, while some instructors may be surprised at such things as the absence of the possessive pronoun, no insistence on the use of optional subjunctives, and no active treatment of the relative dont, others may be disturbed by what we still include in a first-year text. What we do expect students to acquire (which is quantitatively less than what we present in the text for them to know about), we believe they will acquire well, providing a sound basis for further study (formal or informal) and permitting us to say to them, both during and at the end of the course, "Chapeau!"

Short Description:
Proteins play vital roles in most biological processes; these roles include acting as catalysts for physiological reactions, as regulators for those reactions, or as structural framework around which these processes can occur. Proteins’ complex organization of diverse functionality in 3D space leads to an astonishing range of function for living organisms. Understanding this intimate relationship between structure and function is the backbone of understanding the natural world and is the key to controlling it. Data dashboard

Word Count: 13793

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

This course uses an open textbook University of Michigan Chemical Engineering Process Dynamics and Controls. The articles in the open textbook (wikibook) are all written by teams of 3-4 senior chemical engineering students, and are peer-reviewed by other members of the class. Using this approach, the faculty and Graduate Student Instructors (GSIs) teaching the course act as managing editors, selecting broad threads for the text and suggesting references. In contrast to other courses, the students take an active role in their education by selecting which material in their assigned section is most useful and decide on the presentation approach. Furthermore, students create example problems that they present in poster sessions during class to help the other students master the material.

Chemistry is designed to meet the scope and sequence requirements of the two-semester general chemistry course. The textbook provides an important opportunity for students to learn the core concepts of chemistry and understand how those concepts apply to their lives and the world around them. The book also includes a number of innovative features, including interactive exercises and real-world applications, designed to enhance student learning.

Chemistry: Atoms First is a peer-reviewed, openly licensed introductory textbook produced through a collaborative publishing partnership between OpenStax and the University of Connecticut and UConn Undergraduate Student Government Association.

This title is an adaptation of the OpenStax Chemistry text and covers scope and sequence requirements of the two-semester general chemistry course. Reordered to fit an atoms first approach, this title introduces atomic and molecular structure much earlier than the traditional approach, delaying the introduction of more abstract material so students have time to acclimate to the study of chemistry. Chemistry: Atoms First also provides a basis for understanding the application of quantitative principles to the chemistry that underlies the entire course.

Chemistry Techniques and Explorations (2023) by Dr. Daniel R. Albert is an eTextbook laboratory manual for first semester introductory chemistry courses. The manual includes two different types of experiments (Technique and Exploration) designed to engage students in chemistry laboratory practices. Technique laboratories are designed for students to learn and practice chemistry laboratory skills that are utilized in a wide variety of disciplines. Exploration laboratories provide freedom and time for students to use previously acquired skills toward answering a new application focused question. Exploration laboratories help build the scientific thinking skills necessary to approach novel problems. The goal of this lab manual is to build both fundamental techniques and problem-solving skills that aid students in becoming practicing scientists.

People around the world are fascinated about the preparation of food for eating. There are countless cooking books, TV shows, celebrity chefs and kitchen gadgets that make cooking an enjoyable activity for everyone. The chemistry of cooking course seeks to understand the science behind our most popular meals by studying the behavior of atoms and molecules present in food. This book is intended to give students a basic understanding of the chemistry involved in cooking such as caramelization, Maillard reaction, acid-base reactions, catalysis, and fermentation. Students will be able to use chemistry language to describe the process of cooking, apply chemistry knowledge to solve questions related to food, and ultimately create their own recipes.

Over the years researchers have found the necessity to develop theories of behavior that are specific to family settings. These theories have been developed by people with a variety of areas of emphasis, from family therapists to gerontologists to child development specialists. In this chapter we will briefly discuss six such theories: Bioecological Model, Family Systems, Functionalism, Conflict Theory, Symbolic Interactionism, and Psychological Perspectives.

Welcome to Child Growth and Development. This text is a presentation of how and why children grow, develop, and learn. We will look at how we change physically over time from conception through adolescence. We examine cognitive change, or how our ability to think and remember changes over the first 20 years or so of life. And we will look at how our emotions, psychological state, and social relationships change throughout childhood and adolescence.

Children, Families, Schools, and Communities is an introductory text in the field of Child and Family Studies. It provides a lens for understanding the evolving definition of “family”. It promotes strategies for culturally sustaining and deeply collaborative relationships. Children, Families, Schools, and Communities is an adapted OER text from Rebecca Laff’s and Wendy Ruiz’s "Child, Family, and Community".

The authors of Chinese Rhetoric and Writing offer a response to the argument that Chinese students' academic writing in English is influenced by "culturally nuanced rhetorical baggage that is uniquely Chinese and hard to eradicate." Noting that this argument draws from "an essentially monolingual and Anglo-centric view of writing," they point out that the rapid growth in the use of English worldwide calls for "a radical reassessment of what English is in today's world." The result is a book that provides teachers of writing, and in particular those involved in the teaching of English academic writing to Chinese students, an introduction to key stages in the development of Chinese rhetoric, a wide-ranging field with a history of several thousand years. Understanding this important rhetorical tradition provides a strong foundation for assessing and responding to the writing of this growing group of students.

Choosing & Using Sources presents a process for academic research and writing, from formulating your research question to selecting good information and using it effectively in your research assignments. Additional chapters cover understanding types of sources, searching for information, and avoiding plagiarism. Each chapter includes self-quizzes and activities to reinforce core concepts and help you apply them. There are also appendices for quick reference on search tools, copyright basics, and fair use.

A Holiday Ghost Story by Charles Dickens with Illustrations by John Leech

Short Description:
This version of the classic holiday story has been slightly abridged and lightly adapted for advanced students of English language. The text includes comprehension checks, discussion questions, and collaborative activities. Order a print copy: https://www.lulu.com/en/us/shop/timothy-krause/a-christmas-carol/paperback/product-vqrgq7.html

Long Description:
This version of the classic holiday story has been slightly abridged and lightly adapted for advanced students of English language. The text includes comprehension checks, discussion questions, and collaborative activities.

Word Count: 11147

ISBN: 978-1-63635-010-3

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

This resource is intended for an introductory or intermediate-level college genetics course. It begins with an exploration of DNA and genome structure and continues with a study of the molecular mechanisms that drive gene expression. Concepts of classical transmission genetics are linked to the molecular mechanisms that underlie observable phenotypes. It concludes with specific topics that synthesize information from both molecular and transmission genetics, including consideration of topics like epigenetics, cancer biology, and evolution. Examples of both historical and current problems in genetics are presented, along with conversations of the relationship between genetics and society.

Looting, despoiling temples, attempted rape and judicial murder: these are just some of the themes of this classic piece of writing by one of the world's greatest orators. This particular passage is from the second book of Cicero's Speeches against Verres, who was a former Roman magistrate on trial for serious misconduct. Cicero presents the lurid details of Verres' alleged crimes in exquisite and sophisticated prose.

This volume provides a portion of the original text of Cicero's speech in Latin, a detailed commentary, study aids, and a translation. As a literary artefact, the speech gives us insight into how the supreme master of Latin eloquence developed what we would now call rhetorical "spin". As an historical document, it provides a window into the dark underbelly of Rome's imperial expansion and exploitation of the Near East.

Ingo Gildenhard's illuminating commentary on this A-Level set text will be of particular interest to students of Latin at both high school and undergraduate level. It will also be a valuable resource to Latin teachers and to anyone interested in Cicero, language and rhetoric, and the legal culture of Ancient Rome.

In republican times, one of Rome's deadliest enemies was King Mithridates of Pontus. In 66 BCE, after decades of inconclusive struggle, the tribune Manilius proposed a bill that would give supreme command in the war against Mithridates to Pompey the Great, who had just swept the Mediterranean clean of another menace: the pirates. While powerful aristocrats objected to the proposal, which would endow Pompey with unprecedented powers, the bill proved hugely popular among the people, and one of the praetors, Marcus Tullius Cicero, also hastened to lend it his support. In his first ever political speech, variously entitled pro lege Manilia or de imperio Gnaei Pompei, Cicero argues that the war against Mithridates requires the appointment of a perfect general and that the only man to live up to such lofty standards is Pompey. In the section under consideration here, Cicero defines the most important hallmarks of the ideal military commander and tries to demonstrate that Pompey is his living embodiment.

This course book offers a portion of the original Latin text, study aids with vocabulary, and a commentary. Designed to stretch and stimulate readers, the incisive commentary will be of particular interest to students of Latin at both AS and undergraduate level. It extends beyond detailed linguistic analysis and historical background to encourage critical engagement with Cicero's prose and discussion of the most recent scholarly thought.