Active transport is reliant on carrier proteins and thus follows the same rules as facilitated diffusion in that they are specific have a maximum rate and are subject to competition. Crucially they transport substances against their concentration gradient and so require energy to work.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"In northern ecosystems, winter carbon loss is estimated to exceed growing season carbon uptake, primarily because of microbial decomposition. Viruses in soil alter microbial carbon cycling by affecting metabolic pathways and killing their hosts, but whether viruses are active under anoxic and sub-freezing soil conditions remains unknown. To find out, a recent study used stable isotope probing (SIP) targeted metagenomics to investigate active microbes in Alaskan Arctic peat soils under simulated winter conditions, with a particular focus on viruses and virus-host dynamics. Overall, 46 bacterial and 243 viral populations actively took up soil water labeled with ¹⁸O and respired CO₂. Active bacteria represented a small proportion of the total microbial community but were able to ferment and degrade organic matter. In contrast, a large diversity of viruses were found to be active, one-third of which were linked to active bacteria..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Some pain after a major operation is expected -- but some patients suffer more than others. More than 60% of surgical patients have moderate-to-severe postoperative pain, potentially predisposing them to persistent postsurgical pain. But who falls into which category? To better predict patients’ pain -- and thereby provide better treatment -- researchers at the University of Florida studied a large group of surgical patients to identify different pain trajectories. The team’s work published in _Anesthesiolog_y revealed five distinct patterns determined in large part by patient-specific factors such as age, sex, and psychologic features. The researchers monitored patents’ pain reports for 7 days in 360 patients recovering from a variety of different surgeries. Pain was evaluated using the [Brief Pain Inventory], which asks for a patient’s average, worst, and least pain in the last 24 hours on a scale from zero to 10..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

The Ad*Access Project presents images and database information advertisements printed in U.S. and Canadian newspapers and magazines between 1911 and 1955. This selection of ads is about trains.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Chemotherapy failure is a devastating problem that frequently results from cancer multidrug resistance (MDR). MDR is often due to overexpression of proteins called ABC transporters, which can pump chemotherapy drugs out of cancer cells. However, there are currently no effective treatments for MDR. A new study tested whether adagrasib (MRTX849), a promising anticancer drug targeting a mutant KRAS protein, can help fight MDR in cancer cell lines overexpressing the ABC transporter ABCB1 and in mice with ABCB1-overexpressing tumors. Both in vitro and in vivo, adagrasib increased the anticancer efficacy of conventional chemotherapy drugs. Adagrasib did not change the expression level or location of ABCB1 in the cells to exert its MDR- reversing effects. Rather, it suppressed the ability of ABCB1 to pump the drugs out of the cancer cells, likely by preventing binding of the energy molecule ATP, which normally powers the transporter’s pumping action..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Learn about how organisms adapt to their habitats. This video is part of The Virtual School's "Adapting and Living Together" chapter within our Ecology and Environment topic.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Cases of the fungal disease candidiasis in infants have been increasing over the past two decades, but our understanding of the behavior and evolution of Candida spp. outside laboratory models has been lacking. Researchers assembled new C. albicans and C. parapsilosis genomes using data from premature infant feces, hospital surfaces, clinical samples, and non-hospital environmental samples. Relative to an existing reference genome, the C. parapsilosis genomes analyzed had genomic “hotspots” of single nucleotide variants, and the C. parapsilosis genomes from premature infants had hotspots that matched hospital and subway surface samples, which may suggest a common ancestor. The researchers also analyzed a microbial gene expression time course in one infant being treated for Candida infection. The in situ transcriptomic profiles were highly variable relative to cultured C..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

An introduction to the chapter "Adapting and Living Together" within the Ecology and Environment topic of the virtual school GCSE Biology.

Finches on the Galapagos Islands have evolved to exploit almost every possible niche. This diagram shows the range of food sources available on the island and the different beak shapes adapted to exploit each of them.

This is a lesson for teaching 1st graders on how to use a number line to help them with number sense and understanding addition before they learn subtraction. Number lines can also aid in the concept of subraction. 

Poster showing a woman attaching a triangle to complete a five-pointed star "Victory." Woman's Committee, Liberty Loan Organization, Seventh Federal Reserve District. W.L.L.C. X5.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Many microbiome studies have matched-pair or matched-set designs, in which data naturally cluster into sets, with some within-set variation in traits of interest. Statistical methods help us make sense of these data, testing hypotheses at the community or operational taxonomic unit (OTU) level. Now, researchers present a new strategy for analyzing matched-set microbial data. The method can be used with both PERMANOVA, a commonly used distance-based method for testing hypotheses at the community level, and the linear decomposition model (LDM), which unifies the community-level and OTU-level tests into one framework. An indicator variable for each set is included as a covariate to constrain comparisons between samples within a set. Simulations using this method showed that the strategy outperformed alternative strategies in a wide range of scenarios, and the flexibility of these methods to allow discrete or continuous traits or interactions to be tested was illustrated with analysis of two real datasets..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In this episode of Crash Course Psychology, Hank has a look at that oh so troublesome time in everyone's life: Adolescence! He talks about identity, individuality, and The Breakfast Club.

In this episode of Crash Course Psychology, Hank has a look at that oh so troublesome time in everyone's life: Adolescence! He talks about identity, individuality, and The Breakfast Club.

The adrenal glands are paired bodies lying cranial to the kidneys within the retroperitoneal space. The glands consist of two layers; the cortex and medulla.

The adrenal glands are paired bodies lying cranial to the kidneys within the retroperitoneal space. The glands consist of two layers; the cortex and medulla.

U.S. Army recruiting poster showing a soldiers on horseback with team of horses pulling artillery. A.G.O.R.S. no. 212, 12-8-19.

A folding comic puzzle in which the heads of Confederate General P.G.T. Beauregard and a donkey switch bodies. An example of mass of anti-Beauregard material published in the north after the outbreak of hostilities leading to Civil War.|Published by Samuel Upham, 310 Chestnut Street, Philadelphia. Entered according to Act of Congress, in the year 1861, by Samuel C. Upham, 310 Chestnut St., Philadelphia, in the Clerk's Office of the District Court of the United States, in and of the Eastern District of Pennsylvania.|Title appears as it is written on the item.|Forms part of: American cartoon print filing series (Library of Congress)