This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Cytotoxic T lymphocytes such as T and NK cells are critically involved in the immune response to cancer development. Their cell-surface receptors coordinate to precisely regulate their function, and dysregulation of these molecules has been linked to immune escape. A recent study identified molecules targeting one of these receptors: T cell immunoglobulin and ITIM domain (TIGIT). TIGIT is a novel immune checkpoint molecule involved in T and NK cell anergy. Binding with its ligand, PVR, can induce immune tolerance, allowing cancer cells to escape immune surveillance. To facilitate the design of inhibitors targeting TIGIT/PVR binding, researchers examined the binding interaction in silico. Their results suggested that the loops of PVR undergo a major rearrangement upon binding to TIGIT. The potential residues critical for the TIGIT/PVR interaction were discovered, and simulation analysis identified four PVR mutants with enhanced affinity to TIGIT..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

These are interactive lecture-demonstration questions probe student understanding of fundamental concepts in the photoelectric effect.

Using highly interactive learning design, this Concepts in Statistics course provides students with a strong understanding of fundamental principles that guide the study of statistical inference. Drawing from Open Learning Initiative (OLI) source content, this course’s simulations and lab-style synthesis activities invite hands-on exploration of statistical concepts. Students learn to summarize data graphically and numerically; examine relationships among quantitative data; understand the role of probability and probability distributions; link probability to statistical inference; and conduct foundational statistical calculations and analyses.

This interactive, scaffolded activity allows students to build an atom within the framework of a newer orbital model. It opens with an explanation of why the Bohr model is incorrect and provides an analogy for understanding orbitals that is simple enough for grades 8-9. As the activity progresses, students build atoms and ions by adding or removing protons, electrons, and neutrons. As changes are made, the model displays the atomic number, net charge, and isotope symbol. Try the "Add an Electron" page to build electrons around a boron nucleus and see how electrons align from lower-to-higher energy. This item is part of the Concord Consortium, a nonprofit research and development organization dedicated to transforming education through technology. The Concord Consortium develops deeply digital learning innovations for science, mathematics, and engineering. The models are all freely accessible. Users may register for additional free access to capture data and store student work products.

This interactive activity helps learners visualize the role of electrons in the formation of ionic and covalent chemical bonds. Students explore different types of chemical bonds by first viewing a single hydrogen atom in an electric field model. Next, students use sliders to change the electronegativity between two atoms -- a model to help them understand why some atoms are attracted. Finally, students experiment in making their own models: non-polar covalent, polar covalent, and ionic bonds. This item is part of the Concord Consortium, a nonprofit research and development organization dedicated to transforming education through technology.

This 90-minute activity features six interactive molecular models to explore the relationships among voltage, current, and resistance. Students start at the atomic level to explore how voltage and resistance affect the flow of electrons. Next, they use a model to investigate how temperature can affect conductivity and resistivity. Finally, they explore how electricity can be converted to other forms of energy. The activity was developed for introductory physics courses, but the first half could be appropriate for physical science and Physics First. The formula for Ohm's Law is introduced, but calculations are not required. This item is part of the Concord Consortium, a nonprofit research and development organization dedicated to transforming education through technology. The Concord Consortium develops deeply digital learning innovations for science, mathematics, and engineering.

This concept-building activity contains a set of sequenced simulations for investigating how atoms can be excited to give off radiation (photons). Students explore 3-dimensional models to learn about the nature of photons as "wave packets" of light, how photons are emitted, and the connection between an atom's electron configuration and how it absorbs light. Registered users are able to use free data capture tools to take snapshots, drag thumbnails, and submit responses. This item is part of the Concord Consortium, a nonprofit research and development organization dedicated to transforming education through technology.

In this interactive activity, learners explore factors that cause atoms to form (or break) bonds with each other. The first simulation depicts a box containing 12 identical atoms. Using a slider to add heat, students can see the influence of temperature on formation of diatomic bonds. Simulations #2 and #3 introduce learners to reactions involving two types of atoms. Which atom forms a diatomic molecule more easily, and why? The activity concludes as students explore paired atoms (molecules). In this simulation they compare the amount of energy needed to break the molecular bonds to the energy needed to form the bonds. This item is part of the Concord Consortium, a nonprofit research and development organization dedicated to transforming education through technology.

In this interactive activity, learners build computer models of atoms by adding or removing electrons, protons, and neutrons. It presents the orbital model of an atom: a nucleus consisting of protons and neutrons with electrons surrounding it in regions of high probability called orbitals. Guided tasks are provided, such as constructing a lithium atom and a carbon-12 atom in the fewest possible steps. The activity concludes with a model for building a charged hydrogen atom (an ion). Within each task, students take snapshots of their work product and answer probative questions. This item is part of the Concord Consortium, a nonprofit research and development organization dedicated to transforming education through technology.

Elementary grade students investigate heat transfer in this activity to design and build a solar oven, then test its effectiveness using a temperature sensor. It blends the hands-on activity with digital graphing tools that allow kids to easily plot and share their data. Included in the package are illustrated procedures and extension activities. Note Requirements: This lesson requires a "VernierGo" temperature sensing device, available for ~ $40. This item is part of the Concord Consortium, a nonprofit research and development organization dedicated to transforming education through technology. The Consortium develops digital learning innovations for science, mathematics, and engineering.

This activity involves an investigation into whether items in a classroom are conductors or insulators. The students predict and then test the items using a complete circuit they have built.

This activity represents a culmination project for this unit by means of which students can assess whether the IPCC prediction of increased storminess as an outcome of global warming survives testing. For the previous three weeks students will have conducted several inquiry-based group activities designed to introduce and reinforce fundamental meteorology/climatology concepts. In this 2-day project, students access online AVHRR SST imagery, as well as tabulated numeric data regarding historical North American tropical cyclones, import data into Excel for interpretation and analysis, and submit two group reports.

(Note: this resource was added to OER Commons as part of a batch upload of over 2,200 records. If you notice an issue with the quality of the metadata, please let us know by using the 'report' button and we will flag it for consideration.)

Explore how populations change over time in a NetLogo model of sheep and grass. Experiment with the initial number of sheep, the sheep birthrate, the amount of energy sheep gain from the grass, and the rate at which the grass re-grows. Remove sheep that have a particular trait (better teeth) from the population, then watch what happens to the sheep teeth trait in the population as a whole. Consider conflicting selection pressures to make predictions about other instances of natural selection.

This unit is designed to build inquiry about and interest in the themes and topics woven throughout Educurious’s multi-unit Washington State History course. To start off, students discover and share how they are connected to their classmates by participating in a “Web of Connectedness” activity. Throughout the unit, students engage in mapping, data visualization, and cost-benefit analyses in order to unpack the theme of connectedness and answer the unit driving question: How are people in Washington connected to each other and the rest of the world? As students learn about resources, economies, innovations, people, and places in Washington, they draft a series of six interactive community boards that educate others about the ways in which people are connected. For the culminating product of this unit, student teams finalize one of their six draft community boards to help students in their school make connections between themselves, Washington, and the world.

Numerical models are widely used to simulate systems ranging from climate to traffic jams, yet a high percentage of college-level students have little awareness of how they are constructed and their limitations. This activity is intended to introduce students to the construction and use of a simple conservation equation model using MATLAB. Students will construct, with the help of the instructor, a MATLAB script to simulate inputs and outputs to and from a water tank and the tracking of water volume through time. The activity includes calibration and verification of their model using data on flows observed in the water tank.

(Note: this resource was added to OER Commons as part of a batch upload of over 2,200 records. If you notice an issue with the quality of the metadata, please let us know by using the 'report' button and we will flag it for consideration.)

This lesson allows students the opporutunity to learn through hands-on investigation how to help our water sources one small change at a time. Journey with Pollution Paul and Conservation in a fun interactive story, then have fun working through the lab simulation. Don't forget to learn all about Algal Blooms with the informational Document. Aligned to Utah State SeeD Standards and Next Generation Science Standards. Although this was created for the elementary age level, it can easily be adapted to middle school and even high school. 

This simulation shows the difference between Constant Velocity vs. Constant Acceleration هذه المحاكاة تبين الفرق بين السرعه الثابته والتسارع المستمر في الفيزياء

The simulation shows five different motions in which objects experience constant acceleration, starting from rest. Although each motion is different, the underlying physics is the same. What features of the simulation reinforce the idea that the physics is the same?

An integrated language arts and social studies unit designed to develop student’s literacy skills while giving them an understanding of the general purpose of government, the structure and processes of Washington’s state government, and the rights and responsibilities of citizenship. The unit culminates with an optional mock legislature simulation that has students write and argue for a bill.

The objective of this lesson is to introduce students to rainfall-runoff modeling using machine learning algorithms. In this lesson, students will walk through the process of accessing data, visualizing the data, statistically analyzing the data and using machine learning software packages to construct rainfall-runoff models.

(Note: this resource was added to OER Commons as part of a batch upload of over 2,200 records. If you notice an issue with the quality of the metadata, please let us know by using the 'report' button and we will flag it for consideration.)