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Apoptotic mimicry as a strategy for the establishment of parasitic infections
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Parasitic infections affect nearly 1 in 6 people worldwide. These infections thrive when parasites are able to evade, inhibit, or disrupt host defense mechanisms. One way parasites avoid the immune response is to disguise themselves as dying host cells. Normal host cells undergoing apoptosis expose a molecule called phosphatidylserine (PS) on the plasma membrane as a signal to surrounding cells. This signal is detected by phagocytic immune cells, which engulf the dying cell and reduce inflammation. The system is co-opted by parasites, who use PS as a Trojan horse to enter phagocytic immune cells, infecting the host. This process, known as “apoptotic mimicry, ”takes several forms. Classical apoptotic mimicry - where the PS comes from the challenger - is used by the parasites that cause leishmaniasis, American trypanosomiasis, and toxoplasmosis; while non-classical apoptotic mimicry, which co-opts PS exposed by dying host cells, is used by the parasites that cause malaria and amebiasis..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
10/29/2020
Apostila bolsas de Banner
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CC BY-NC-ND
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Essa apostila é fruto de uma pesquisa desenvolvida no Programa de Pós-Graduação em Ensino de Ciências Ambientais (PROFCIAMB), oferecido pela Universidade Estadual de Maringá – PR, Campus Regional de Goioerê. Apresentamos neste material métodos para elaboração de bolsas de Banner através do reaproveitamento, trabalhando conceitos de Sustentabilidade e Educação ambiental como ferramentas para a geração de renda.

Subject:
Arts and Humanities
Visual Arts
Material Type:
Homework/Assignment
Author:
Julyana Biavatti
Date Added:
03/20/2024
Apostrophes and plurals
Conditional Remix & Share Permitted
CC BY-NC-SA
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There is *one* extremely rare case in which we use apostrophes to make things plural. David and Paige, KA's resident grammarians, discuss this unusual case.

Subject:
English Language Arts
Language, Grammar and Vocabulary
Material Type:
Lesson
Provider:
Khan Academy
Provider Set:
Khan Academy
Author:
David Rheinstrom
Date Added:
07/29/2021
The Apotheosis
Unrestricted Use
Public Domain
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The print is a fragment of a larger lithograph entitled "Invasion of Cuba," composed of two panels, applauding American "filibustering" expeditions to liberate Cuba from Spain. (See also "The Great Naval Blockade of Round Island" and "Genl Lopez the Cuban Patriot Getting His Cash," nos. 1849-5 and 1850-10.) "Invasion of Cuba" evidently appeared in the wake of Lopez's second failed invasion of Cuba in August 1851. The left panel, "The Expedition," expresses sympathy with American intervention there in defiance of Great Britain. Our panel criticizes the Fillmore administration's conciliatory attitude toward Cuba, and alignment of the island's Spanish rule with the Catholic Church and other conservative powers in Europe. Spanish governor Jose Gutierez de la Concha sits on a throne in the center of a crowded scene, his left foot on the face of the recumbent female figure of Cuba, as he decorates American consul A. F. Owen, who kneels at left. In the right foreground American Secretary of State Daniel Webster holds a "Secret Treaty with Spain" in one hand and behind his back clasps hands with Britain, represented by a lion in sailor's costume. Nearby stands a fox in uniform, probably representing France. To the right of the throne stand various prelates, bishops, and the pope, along with several beasts wearing crowns. On the left of the throne are ministers with star-shaped heads, in a state of agitation. In the left foreground Brother Jonathan, smoking a cigar and waving a saber, carries off a Cuban flag. Above Gutierez's throne are several smaller scenes of Spanish atrocities. On the left is the execution by a Cuban firing squad of American volunteers under W. H. Crittenden in Havana, August 16, 1851. The captive Americans are bound and kneeling. In the center, expedition commander Narciso Lopez is garroted by a black man, as he sits in a chair decorated with a small cross (an anti-Catholic reference). The scene on the right shows two ships, one American and one Cuban, and has the date August 13. It may represent the capture of Crittenden's retreating forces on the high seas. Below the print is the caustic commentary: "Our Consul at Havana decorated by Don Quixote with the Order of the Golden Fleeze for his Neutrality in the Cuba Question under the Applause of the Absolute Powers! The Stars in Consternation. Jonathan runs off swearing: 'Cuba must be smoked' anyhow!"|Signed with monogram: AW.|Title appears as it is written on the item.|Murrell, p. 188-189 (reproduces the complete print).|Weitenkampf, p. 104.|Forms part of: American cartoon print filing series (Library of Congress)|Published in: American political prints, 1766-1876 / Bernard F. Reilly. Boston : G.K. Hall, 1991, entry 1851-4.

Subject:
History
U.S. History
Material Type:
Diagram/Illustration
Primary Source
Provider:
Library of Congress
Provider Set:
Library of Congress - Cartoons 1766-1876
Date Added:
06/13/2013
App Authors
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CC BY-NC-SA
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The App Authors program helps librarians and K-12 educators make coding and app production part of their curriculum.
Our App Authors curriculum provides lesson plans and app development activities that can be used in a seven-week sequential course, in a seven-week semi-sequential course, or in one-time learning sessions.

Subject:
Applied Science
Material Type:
Activity/Lab
Date Added:
04/17/2018
App EcoGuardiões da Comunidade
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CC BY-NC-ND
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O app EcoGuardiões da Comunidade parte da necessidade de se criar uma ferramenta lúdica e acessível de promoção da Educação Ambiental e de cadeias econômicas de Turismo de Base Comunitária, integrando comunidades e escolas. O aplicativo possibilita o entretenimento educativo com o Quiz Ecológico e Dica EcoGuardiã, reunir informações locais e globais para sensibilização sobre a temática ambiental e sobre roteiros, produtos e atrativos deste turismo voltado ao bem viver, com espaços para avaliação e agendamento de visitas às comunidades periféricas e/ou tradicionais, criar uma Rede de Guardiões Socioambientais para articulações, denúncias ambientais e alimentação do próprio app através do elo entre comunidades e escolas, auxiliando assim no fortalecimento da participação coletiva, identificação e pertencimento com a estes espaços.

Subject:
Applied Science
Environmental Science
Material Type:
Game
Interactive
Author:
Anézia Maria Fonsêca Barbosa
Marcio Eric Figueira dos Santos
Date Added:
06/10/2022
App GeoSensor
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CC BY-NC-ND
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O aplicativo GeoSensor é o produto técnico da dissertação de mestrado intitulada: App GeoSensor, Geotecnologias Aplicadas ao Ensino das Ciências Ambientais, apresentada ao Programa de Pós-Graduação em Rede Nacional para Ensino das Ciências Ambientais – Profciamb, núcleo UFPA. O app foi concebido como uma forma de disseminar conhecimentos em Geotecnologias, de maneira didática e acessível, além de fazer paralelo com conhecimentos de disciplinas curriculares, como matemática, física e química, de modo a servir como incentivo ao Ensino de Ciências Ambientais, despertando o interesse dos alunos, utilizando exemplos de aplicações práticas de conceitos vistos em sala de aula, além de possibilitar aos educadores demonstrar as aplicações do conhecimento obtido em sala na vida de todos.
O aplicativo foi desenvolvido tendo como público-alvo discentes e docentes do ensino médio, com possibilidades de aplicação também a partir do ensino fundamental 2, bem como em níveis técnico e superior.

Subject:
Geology
Physical Science
Material Type:
Diagram/Illustration
Lesson
Author:
João Paulo Abreu Almeida
Date Added:
01/17/2022
Apparel Measurements for Fashion Design
Conditional Remix & Share Permitted
CC BY-NC-SA
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Throughout this lesson, the students will learn how to correctly take measurements to create a fitted garment. Students will begin with brainstorming measuring tools. Next, they will discuss fabric sizing as a class. Students will learn about the history of measurements and why it is important to take measurements. Individuals will team up in pairs to practice taking measurement. Finally, students will apply the measurements by comparing and contrasting them with a home-sew pattern.  This lesson could be used before a student begins creating a garment for themselves, especially in Intro to Design or an Apparel Production & Construction course.

Subject:
Architecture and Design
Career and Technical Education
Material Type:
Lesson Plan
Author:
Audrey Foster
Date Added:
06/08/2023
Appeal From John Redmond, M.P., to the People of Ireland
Unrestricted Use
Public Domain
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Title from item. Poster is text only, with lengthy message encouraging enlistment and support of the war effort.

Subject:
History
U.S. History
Material Type:
Diagram/Illustration
Primary Source
Provider:
Library of Congress
Provider Set:
Library of Congress - World War I Posters
Date Added:
06/18/2013
Appeal to Women. Make Every Penny Do the Work of Two. Put Your Savings in the War Loan
Unrestricted Use
Public Domain
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Poster showing ribbons linking Wedgewood-style plaques depicting soldiers. Title from item. Poster no. 5. W.6398, 20M - 7/15.

Subject:
History
U.S. History
Material Type:
Diagram/Illustration
Primary Source
Provider:
Library of Congress
Provider Set:
Library of Congress - World War I Posters
Date Added:
06/18/2013
Appearance and Reality
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CC BY
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PowerPoint slides with a small biography of Russell Bertrand and some of his thoughts on apperance and reality. There are also some slides where I give my interpretations on some of Russell's thoughts.

Subject:
Philosophy
Material Type:
Homework/Assignment
Author:
Michael Rauschenbach
Date Added:
12/07/2022
Appearance vs. Reality
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CC BY-NC-SA
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Students will consider the difference what is shared online and what might be going unshared.  What you see is not always what is real.  This lesson is part of a media unit curated at our Digital Citizenship website, "Who Am I Online?".

Subject:
Communication
English Language Arts
Material Type:
Activity/Lab
Lesson
Lesson Plan
Author:
Dana John
Beth Clothier
John Sadzewicz
Angela Anderson
Date Added:
06/14/2020