Epigenetics - our epigenome - controls how our genes behave without altering their sequence. Just about everything affects it, from nutrition, drugs, and toxins to child rearing, culture, and society. Many diseases, from obesity to addiction to cancer, can be linked to epigenetic modifications. Furthermore, throughout development and life, from conception to death, the exposures you have will not only affect your own epigenome, but potentially also your child’s, and your grandchild’s. This rapidly expanding field of biological, physiological, sociological, and psychological research could be key to discovering why, and more importantly how, we are the way we are.

Epigenetics has consequences for medicine, pregnancy, childcare, law and how we live on an everyday basis. This book will provide a comprehensive introduction to the mechanisms and real-life consequences of epigenetics, and will arm the reader with the knowledge necessary to make informed decisions about the future of epigenetics in modern society. This is a call for serious consideration about the effects of epigenetics on society.

This resource, provided by Wisconsin Fast Plants and CurrikiStudio, contains a set of six different learning activities that can be implemented in classrooms to teach natural selection. Organized in playlists, these interactive lessons guide students through understanding and applying knowledge of natural selection. The specific playlists and modules include: Population Pre-think for discussion: Factors that affect traits in populations Checking for understanding: Investigating Change Over Time in Populations Exploring Selection Models Looking for Evidence in Data Selection Models Genetics Review The Language of Genetics Looking for Patterns and Analyzing Population Data

The purpose of this lesson is to research artificial selection. During this lesson, we will use fast growing plant crossing to model traditional agricultural practices and we will use Punnett squares to predict plant crossing outcomes. We will also use online simulations to learn about current biotechnology techniques used to make genetically modified crops. We will compare traditional agriculture to current biotechnology techniques that are being used to create pest resistant crops. We will discuss how artificial selection such as selective breeding and genetic engineering can impact organisms over time.

A hypothetical scenario is introduced in which the class is asked to apply their understanding of the forces that drive natural selection to prepare a proposal along with an environmental consulting company to help clean up an area near their school that is contaminated with trichloroethylene (TCE). Students use the Avida-ED software application to test hypotheses for evolving (engineering) a strain of bacteria that can biodegrade TCE, resulting in a non-hazardous clean-up solution. Conduct this design challenge activity after completion of the introduction to digital evolution activity, Studying Evolution with Digital Organisms.

In this class, students engage in independent research projects to probe various aspects of the physiology of the bacterium Pseudomonas aeruginosa PA14, an opportunistic pathogen isolated from the lungs of cystic fibrosis patients. Students use molecular genetics to examine survival in stationary phase, antibiotic resistance, phase variation, toxin production, and secondary metabolite production.
Projects aim to discover the molecular basis for these processes using both classical and cutting-edge techniques. These include plasmid manipulation, genetic complementation, mutagenesis, PCR, DNA sequencing, enzyme assays, and gene expression studies. Instruction and practice in written and oral communication are also emphasized.
WARNING NOTICE
The experiments described in these materials are potentially hazardous and require a high level of safety training, special facilities and equipment, and supervision by appropriate individuals. You bear the sole responsibility, liability, and risk for the implementation of such safety procedures and measures. MIT shall have no responsibility, liability, or risk for the content or implementation of any of the material presented.
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This project-based laboratory course provides students with in-depth experience in experimental molecular genetics, using modern methods of molecular biology and genetics to conduct original research. The course is geared towards students (including sophomores) who have a strong interest in a future career in biomedical research. This semester will focus on chemical genetics using Caenorhabditis elegans as a model system. Students will gain experience in research rationale and methods, as well as training in the planning, execution, and communication of experimental biology.
WARNING NOTICE
The experiments described in these materials are potentially hazardous and require a high level of safety training, special facilities and equipment, and supervision by appropriate individuals. You bear the sole responsibility, liability, and risk for the implementation of such safety procedures and measures. MIT shall have no responsibility, liability, or risk for the content or implementation of any of the material presented.
Legal Notice

Download this complete and coherently designed, middle school level unit to teach fundamental concepts that underpin the theory of evolution. The unit was collaboratively designed by teachers, college faculty & staff, and the Fast Plants Program at UW-Madison to support student-centered inquiry-based learning. The unit's storyline is underpinned by the 5E model. Like three dimensional learning as described by the Next Generation Science Standards, this unit is designed for students to learn academic content by working like scientists: making observations, asking questions, doing further investigations to explore and explain natural phenomena, and communicating results based on evidence. Immersion Units are intended to support teachers in building a learning culture in their classrooms to sustain students’ enthusiasm for engaging in scientific habits of thinking while learning rigorous science content.

Why do some organisms go extinct? What impact do humans play in the extinction of animals? What can we do about it? If something is extinct is it truly gone forever? These are some of the major questions that conservation biologists are currently asking. Extinction is when a species no longer has any living members in the wild or in captivity. Extinction can happen for a number of reasons including habitat loss, overhunting, and climate change. Mass extinction is widespread extinction across many species. Right now, we are experiencing the sixth mass extinction event on Earth and it has been primarily caused human activity. Conservation biologists have been hard at work coming up with solutions to prevent extinction of organisms at risk, however, extinction still occurs. But does it have to be permanent? This module walks students through the major processes that cause extinction, what strategies conservation has used so far to prevent extinction, what de-extinction is, and what consequences de-extinction may have through the use of videos, research, and a class debate. 

Studying the Fibonacci Sequence is our entry point for studying Heredity: Inheritance and variation of traits.

Sign up for a free account on the Gizmo website (https://www.explorelearning.com/index.cfm?method=Controller.dspFreeAccount) for free access to two simulations that were collaboratively developed by the teams at Explore Learning and the Wisconsin Fast Plants Program of the University of Wisconsin-Madison. These simulations replace those previously available on our website that were developed nearly two decades ago and no longer function on modern operating systems. Fast Plants Gizmos were created as a collaboration between ExploreLearning and the Wisconsin Fast Plants Program of the University of Wisconsin-Madison. They weredesigned to support many of the experiments that students can do using Fast Plants seeds and plants. By using these Gizmos in combination with firsthand experiences growing Fast Plants, students can compare simulated growth, development and reproduction with observations of living Fast Plants. In addition, the Gizmos genetic simulation makes it possible for students to gather data from a significantly larger plant population than is typically grown in classrooms. These Gizmos also stand alone, supporting topics both in plant life cycles and Mendelian genetics and can be used by any student. Simulation, Simulations, Genetics, Inheritance

Instructional video on the formation of catenane after replication of circular bacterial chromosome.

Although textbooks describe this process and show illustrations, it is difficult to grasp without seeing a live demonstration.

Created for Biology 41 General Genetics at Tufts University.

Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick, the information on detailed molecular structures of DNA and RNA, namely, the foundation of genetic material, has expanded rapidly. This discovery is the beginning of the “Big Bang” of molecular biology and biotechnology. In this seminar, students discuss, from a historical perspective and current developments, the importance of pursuing the detailed structural basis of genetic materials.

For more than two decades J. Craig Venter and his research teams have been pioneers in genomic research. Regarded as one of the leading scientist of the 21st century, Venter discusses how he is applying tools and techniques developed to sequence the human genomes to discover new genes of microbes from around the world. (57 minutes)

Introduction to gel electrophoresis. How it's used to separate DNA fragments or other macromolecules.

This problem challenges students to design experiments using techniques measuring gene expression (reverse transcriptase PCR, microarrays, in situ hybridization).

Express yourself through your genes! See if you can generate and collect three types of protein, then move on to explore the factors that affect protein synthesis in a cell.

Build a gene network! The lac operon is a set of genes which are responsible for the metabolism of lactose in some bacterial cells. Explore the effects of mutations within the lac operon by adding or removing genes from the DNA.

Build a gene network! The lac operon is a set of genes which are responsible for the metabolism of lactose in some bacterial cells. Explore the effects of mutations within the lac operon by adding or removing genes from the DNA.

An integrated course stressing the principles of biology. Life processes are examined primarily at the molecular and cellular levels. Intended for students majoring in biology or for non-majors who wish to take advanced biology courses.