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CK-12 Biology (CA Textbook)
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Submitted as part of the California Learning Resource Network (CLRN) Phase 3 Digital Textbook Initiative (CA DTI3), CK-12 Foundation’s high school Biology FlexBook covers cell biology, genetics, evolution, ecology, botany, zoology, and physiology. This digital textbook was reviewed for its alignment with California content standards.

Subject:
Biology
Ecology
Genetics
Life Science
Material Type:
Textbook
Provider:
CK-12 Foundation
Provider Set:
CK-12 FlexBook
Author:
Douglas Wilkin Ph.D.
Date Added:
02/16/2011
CLONING
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CC BY-NC-ND
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cloning is the process of producing similar populations of genetically identical individuals that occurs in nature when organisms such as bacteria, insects or plants reproduce asexually.
Advantages and Disadvantages of cloning.

Subject:
Applied Science
Material Type:
Assessment
Date Added:
11/15/2017
Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students
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Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students (2021) is an undergraduate medical-level resource for foundational knowledge across the disciplines of genetics, cell biology and biochemistry. This USMLE-aligned text is designed for a first-year undergraduate medical course that is delivered typically before students start to explore systems physiology and pathophysiology. The text is meant to provide the essential information from these content areas in a concise format that would allow learner preparation to engage in an active classroom. Clinical correlates and additional application of content is intended to be provided in the classroom experience. The text assumes that the students will have completed medical school prerequisites (including the MCAT) in which they will have been introduced to the most fundamental concepts of biology and chemistry that are essential to understand the content presented here. This resource should be assistive to the learner later in medical school and for exam preparation given the material is presented in a succinct manner, with a focus on high-yield concepts.

The 276-page text was created specifically for use by pre-clinical students at Virginia Tech Carilion School of Medicine and was based on faculty experience and peer review to guide development and hone important topics.

Available Formats
978-1-949373-42-4 (PDF)
978-1-949373-43-1 (ePub) [coming soon]
978-1-949373-41-7 (Pressbooks) https://pressbooks.lib.vt.edu/cellbio
Also available via LibreTexts: https://med.libretexts.org/@go/page/37584

How to Adopt this Book
Instructors reviewing, adopting, or adapting parts or the whole of the text are requested to register their interest at: https://bit.ly/interest-preclinical.

Instructors and subject matter experts interested in and sharing their original course materials relevant to pre-clinical education are requested to join the instructor portal at https://www.oercommons.org/groups/pre-clinical-resources/10133.

Features of this Book
1. Detailed learning objectives are provided at the beginning of each subsection
2. High resolution, color contrasting figures illustrate concepts, relationships, and processes throughout
3. Summary tables display detailed information
4. End of chapter lists provide additional sources of information
5. Accessibility features including structured heads and alternative-text provide access for readers accessing the work via a screen-reader

Table of Contents
1. Biochemistry basics
2. Basic laboratory measurements
3. Fed and fasted state
4. Fuel for now
5. Fuel for later
6. Lipoprotein metabolism and cholesterol synthesis
7. Pentose phosphate pathway (PPP), purine and pyrimidine metabolism
8. Amino acid metabolism and heritable disorders of degradation
9. Disorders of monosaccharide metabolism and other metabolic conditions
10. Genes, genomes, and DNA
11. Transcription and translation
12. Gene regulation and the cell cycle
13. Human genetics
14. Linkage studies, pedigrees, and population genetics
15. Cellular signaling
16. Plasma membrane
17. Cytoplasmic membranes
18. Cytoskeleton
19. Extracellular matrix

Suggested Citation
LeClair, Renée J., (2021). Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students, Blacksburg, VA: Virginia Tech Publishing. https://doi.org/10.21061/cellbio. Licensed with CC BY NC-SA 4.0.

About the Author
Renée J. LeClair is an Associate Professor in the Department of Basic Science Education at the Virginia Tech Carilion School of Medicine, where her role is to engage activities that support the departmental mission of developing an integrated medical experience using evidence-based delivery grounded in the science of learning. She received a Ph.D. at Rice University and completed a postdoctoral fellowship at the Maine Medical Center Research Institute in vascular biology. She became involved in medical education, curricular renovation, and implementation of innovative teaching methods during her first faculty appointment, at the University of New England, College of Osteopathic Medicine. In 2013, she moved to a new medical school, University of South Carolina, School of Medicine, Greenville. The opportunities afforded by joining a new program and serving as the Chair of the Curriculum committee provided a blank slate for creative curricular development and close involvement with the accreditation process. During her tenure she developed and directed a team-taught student-centered undergraduate medical course that integrated the scientific and clinical sciences to assess all six-core competencies of medical education.

Accessibility Note
The University Libraries at Virginia Tech and Virginia Tech Publishing are committed to making its publications accessible in accordance with the Americans with Disabilities Act of 1990. The HTML (Pressbooks) and ePub versions of this book utilize header structures and include alternative text which allow for machine-readability.

Please report any errors at https://bit.ly/feedback-preclinical

Subject:
Applied Science
Health, Medicine and Nursing
Life Science
Material Type:
Textbook
Provider:
Virginia Tech
Provider Set:
VTech Works
Author:
Renee LeClair
Date Added:
11/20/2021
Cellular Metabolism and Cancer: Nature or Nurture?
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CC BY-NC-SA
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In this course we will explore how altered metabolism drives cancer progression. Students will learn (1) how to read, discuss, and critically evaluate scientific findings in the primary research literature, (2) how scientists experimentally approach fundamental issues in biology and medicine, (3) how recent findings have challenged the traditional “textbook” understanding of metabolism and given us new insight into cancer, and (4) how a local pharmaceutical company is developing therapeutics to target cancer metabolism in an effort to revolutionize cancer therapy.

Subject:
Applied Science
Biology
Genetics
Health, Medicine and Nursing
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Lau, Allison
Lien, Evan
Date Added:
09/01/2018
Chapter 8 Outline
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CC BY-NC-SA
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This outline was created as a lecture outline for my online Fundamentals of Biology course to accompany Concepts of Biology by Open Stax.

Subject:
Biology
Life Science
Material Type:
Lecture Notes
Date Added:
12/24/2018
Chemical brain drain
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CC BY-NC-ND
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Brain development can be damaged by environmental chemicals.
Philippe Grandjean, University of Southern Denmark and Harvard School of Public Health, explains the erroneous assumptions made over time about this. Studies from Faroe Islands, where people have been exposed to toxic agents, shows how this affects brains of children and their IQ levels.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Lecture
Author:
Philippe Grandjean
Date Added:
11/18/2019
Chemicals in the Environment: Toxicology and Public Health (BE.104J)
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CC BY-NC-SA
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This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making. Throughout the term, students consider case studies of local and national interest.

Subject:
Applied Science
Atmospheric Science
Biology
Engineering
Environmental Science
Health, Medicine and Nursing
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Green, Laura
Sherley, James
Tannenbaum, Steven
Date Added:
02/01/2005
Chemicals in the Environment: Toxicology and Public Health (BE.104J)
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CC BY-NC-SA
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This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making. Throughout the term, students consider case studies of local and national interest.

Subject:
Applied Science
Environmental Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
James Sherley
Date Added:
01/01/2005
Children’s health - Risks to brain development from exposure to environmental chemicals
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A presentation with Professor Philippe Grandjean about the dangers of chemical interference with the developing brain. This presentation, “Children’s health - Risks to brain development from exposure to environmental chemicals”, presented on 6th November, 2019, meeting of the French High Council for Public Health (Haut Conseil de la Santé Publique, HCSP), at the Ministry for Solidarity and Health in Paris.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Lecture
Author:
Professor Philippe Grandjean
Date Added:
11/18/2019
Chromosomes, Genes, and Traits: An Introduction to Genetics
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This resource is intended for an introductory or intermediate-level college genetics course. It begins with an exploration of DNA and genome structure and continues with a study of the molecular mechanisms that drive gene expression. Concepts of classical transmission genetics are linked to the molecular mechanisms that underlie observable phenotypes. It concludes with specific topics that synthesize information from both molecular and transmission genetics, including consideration of topics like epigenetics, cancer biology, and evolution. Examples of both historical and current problems in genetics are presented, along with conversations of the relationship between genetics and society.

Subject:
Genetics
Life Science
Material Type:
Full Course
Provider:
Remixing Open Textbooks through an Equity Lens (ROTEL) Project
Author:
Amanda Simons
Date Added:
06/05/2024
Cindy Sheets: Keeping One Step Ahead of Her Gifted Students
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In this online article, from the museum's Musings newsletter for educators, a resource teacher for gifted children discusses how she keeps one step ahead of her students. Cindy Sheets offers tips on devising a dynamic curriculum tackling the ever-changing field of genetics.

Subject:
Education
Genetics
Life Science
Material Type:
Data Set
Provider:
American Museum of Natural History
Provider Set:
American Museum of Natural History
Author:
Cindy Sheets
Date Added:
10/15/2014
Classifying Animals by Appearance Versus DNA Sequence
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The topic of this video module is how to classify animals based on how closely related they are. The main learning objective is that students will learn how to make phylogenetic trees based on both physical characteristics and on DNA sequence. Students will also learn why the objective and quantitative nature of DNA sequencing is preferable when it come to classifying animals based on how closely related they are. Knowledge prerequisites to this lesson include that students have some understanding of what DNA is and that they have a familiarity with the base-pairing rules and with writing a DNA sequence.

Subject:
Biology
Genetics
Life Science
Material Type:
Lecture
Provider:
MIT
Provider Set:
MIT Blossoms
Author:
Megan E. Rokop
Date Added:
06/11/2012
Computation for Biological Engineers
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CC BY-NC-SA
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This course covers the analytical, graphical, and numerical methods supporting the analysis and design of integrated biological systems. Topics include modularity and abstraction in biological systems, mathematical encoding of detailed physical problems, numerical methods for solving the dynamics of continuous and discrete chemical systems, statistics and probability in dynamic systems, applied local and global optimization, simple feedback and control analysis, statistics and probability in pattern recognition.
An official course Web site and Wiki is maintained on OpenWetWare: 20.181 Computation for Biological Engineers.

Subject:
Applied Science
Biology
Computer Science
Engineering
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Alm, Eric
Endy, Andrew
Date Added:
09/01/2006
Concepts of Biology by Rice University Textbook Resources for Biology I
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CC BY-NC-SA
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This is information to be used for a General Biology I (or Introduction to Biology) course for non-science majors.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Full Course
Homework/Assignment
Lecture
Lecture Notes
Lesson Plan
Module
Reading
Student Guide
Syllabus
Teaching/Learning Strategy
Unit of Study
Date Added:
08/10/2019
Conversations with History: Revolution in the Biological Sciences, with Sir John Gurdon
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Host Harry Kreisler Welcomes Professor Sir John Gurdon for a discussion of advances in research on cell biology. Sir John reflects on his career as a scientist including his path breaking research on cloning. He offers insights into the implications of the revolution in the biological sciences.(46 min)

Subject:
Arts and Humanities
Biology
Genetics
Life Science
Material Type:
Lecture
Provider:
UCTV Teacher's Pet
Date Added:
06/13/2010
Crispr Cas9
Unrestricted Use
CC BY
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Precise modification of faulty genes for repair has been one of the most important goals in medicine. It is now finally within the realm of possibility thanks to the gene editing tool CRISPR. This microbial adaptive immune system can copy and cut specific DNA sequences. This animation provides a visual introduction of this revolutionary genetic tool.

Subject:
Applied Science
Genetics
Health, Medicine and Nursing
Life Science
Material Type:
Lecture
Provider:
CUNY Academic Works
Provider Set:
City College
Author:
Chen, Ching-jung
Cheng, Katie
Chowdhury, Abanti Deb
Eng, Timmy
Estevez, Irving
Malik, Rafay
Ndjiharine, Vitjitua
Oviedo, Hysell V.
Date Added:
06/16/2022
DNA Build
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Educational Use
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Students reinforce their knowledge that DNA is the genetic material for all living things by modeling it using toothpicks and gumdrops that represent the four biochemicals (adenine, thiamine, guanine, and cytosine) that pair with each other in a specific pattern, making a double helix. They investigate specific DNA sequences that code for certain physical characteristics such as eye and hair color. Student teams trade DNA "strands" and de-code the genetic sequences to determine the physical characteristics (phenotype) displayed by the strands (genotype) from other groups. Students extend their knowledge to learn about DNA fingerprinting and recognizing DNA alterations that may result in genetic disorders.

Subject:
Applied Science
Engineering
Genetics
Life Science
Material Type:
Activity/Lab
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Denise W. Carlson
Janet Yowell
Malinda Schaefer Zarske
Megan Schroeder
Date Added:
09/18/2014
DNA Forensics and Color Pigments
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Educational Use
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Students perform DNA forensics using food coloring to enhance their understanding of DNA fingerprinting, restriction enzymes, genotyping and DNA gel electrophoresis. They place small drops of different food coloring ("water-based paint") on strips of filter paper and then place one paper strip end in water. As water travels along the paper strips, students observe the pigments that compose the paint decompose into their color components. This is an example of the chromatography concept applied to DNA forensics, with the pigments in the paint that define the color being analogous to DNA fragments of different lengths.

Subject:
Applied Science
Engineering
Genetics
History
History, Law, Politics
Life Science
Physical Science
Physics
Material Type:
Activity/Lab
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Mircea Ionescu
Myla Van Duyn
Date Added:
09/18/2014