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Slc2a6 regulates myoblast differentiation by targeting LDHB
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Type 2 diabetes mellitus often leads to muscle atrophy driven by diminished differentiation capacity in myoblasts. Myogenesis is complex, and while many involved pathways have been described, there may still be yet undiscovered therapeutic targets. With this goal in mind, a recent study combined experiments in diabetic mice and cultured myoblasts to identify key proteins in diabetes-induced atrophy. The gene for the relatively undescribed solute carrier Slc2a6, also known as glut6, was up-regulated during myogenic differentiation and down-regulated during diabetes-induced myopathy. Silencing Slc2a6 with RNAi in cell culture impaired differentiation and myotube formation. Transcriptomics and metabolomics revealed that Slc2a6 silencing disproportionally impacted the glycolysis pathway . Further experiments and analysis determined that Slc2a6 regulates myogenic differentiation in cultured myoblasts and that this regulation was partly through the glycolysis pathway..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
04/14/2023
Torts and Regulation: Cases, Principles, and Institutions
Conditional Remix & Share Permitted
CC BY-NC-SA
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Torts and Regulation: Cases, Principles, and Institutions (TRCPI) is designed to bring together common law principles in the field of torts with related statutory and regulatory materials. The aim is to provide a text that introduces students to key tort principles and the way in which those tort principles have in part shaped the regulatory state and in part been supplanted by the regulatory state.

This casebook increases the role of statutes and regulations in the material. In addition, it offers a major innovation by leading the students into the ways in which basic tort doctrine animate fields of statutory law. In particular, the book adopts a series of “modules” that follow the adoption and adaptation of tort principles in the law of employment discrimination.

The book borrows substantially from a torts casebook co-authored by the author and Karen Tani of the University of California at Berkeley. That book, Torts: Cases, Principles, and Institutions (4th ed., 2019), supplies much of the basic tort material that follows here in TRCPI.

Subject:
Law
Material Type:
Textbook
Provider:
The Center for Computer Assisted Legal Instruction (CALI)
Provider Set:
The eLangdell Bookstore
Author:
John Witt
Date Added:
08/01/2019
Transportation Law and Policy
Conditional Remix & Share Permitted
CC BY-NC
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This OER provides a substantial set of readings on transportation law and policy, suitable for use in a variety of disciplines and educational settings, including law, economics, urban planning, history, engineering, sociology, and more.

Subject:
General Law
Law
Material Type:
Syllabus
Provider:
University of Iowa
Provider Set:
Iowa Research Online
Author:
Gregory H. Shill
Date Added:
06/12/2023
Using Microcontrollers to Model Homeostasis
Read the Fine Print
Educational Use
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Students learn about homeostasis and create models by constructing simple feedback systems using Arduino boards, temperature sensors, LEDs and Arduino code. Starting with pre-written code, students instruct LEDs to activate in response to the sensor detecting a certain temperature range. They determine appropriate temperature ranges and alter the code accordingly. When the temperature range is exceeded, a fan is engaged in order to achieve a cooling effect. In this way, the principle of homeostasis is demonstrated. To conclude, students write summary paragraphs relating their models to biological homeostasis.

Subject:
Biology
Career and Technical Education
Life Science
Material Type:
Activity/Lab
Provider:
TeachEngineering
Author:
Aaron Lamplugh
Date Added:
02/07/2017
Wetlands Law: A Course Source
Conditional Remix & Share Permitted
CC BY-NC-SA
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The Wetlands Law Course Source can be used as the primary text for a two credit seminar or as a supplemental text to cover wetlands material in an environmental law, natural resources law, or water law course. In addition, the administrative law chapter can be used as a supplement in a range of administrative law-related courses, such as environmental law, health law, labor law, immigration law, and others, to introduce basic administrative law concepts.

Unlike traditional casebooks or coursebooks, a “course source” includes resources to train students in all three apprenticeships identified by the Carnegie Foundation in its influential report on legal education, Educating Lawyers: Preparation for the Profession of Law. To address the knowledge apprenticeship, the Wetlands Law Course Source includes all of the traditional elements of a casebook or coursebook (cases, commentary, notes and questions) and includes several hypotheticals and problem exercises that focus on reinforcing wetlands law. In addition, as one of the many forms of summative and formative assessment included in the book, every chapter includes one or more CALI exercise as a “quiz” to reinforce the material covered in the chapter. To address the skills apprenticeship, the Wetlands Law Course Source includes sixteen separate legal research exercises, several drafting exercises, a negotiation exercise, and an interviewing and counseling exercise. To address the values apprenticeship, the Course Source includes several professionalism scenarios, with questions related to the scenarios.

Subject:
Law
Material Type:
Textbook
Provider:
The Center for Computer Assisted Legal Instruction (CALI)
Provider Set:
The eLangdell Bookstore
Author:
Stephen M. Johnson
Date Added:
12/03/2019