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Activating KLF4 to restore MICA levels increases the “killability” of acute myeloid leukemia cells
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Acute myeloid leukemia (AML) is a type of blood and bone marrow cancer with a low survival rate. One reason AML is so deadly is because it can evade the immune system, in part by downregulating proteins like MICA, which normally marks damaged or cancerous cells in the body for immune destruction. To improve treatment prospects, researchers recently searched for molecules that can restore MICA levels in AML cells. They found that the transcription factor KFL4 is involved in MICA expression. In addition, treating cultured AML cells with the KLF4-activating compound APTO253 successfully induced MICA expression, while inhibiting the expression of the cancer gene MYC. These changes made the AML cells more susceptible to being killed by immune cells. Although studies in animals and humans are still needed, these findings reveal that APTO253 can improve immune cells’ ability to detect and kill AML cells and suggest that targeting KFL4/MICA is a promising option for AML treatment..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/08/2023
Active Bystander Intervention: Training and Facilitation Guide
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CC BY
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Training for Preventing and Responding to Sexual Violence in B.C. Post-Secondary Institutions

Short Description:
A workshop and facilitation guide to support B.C. post-secondary institutions to prevent and respond to sexual violence and misconduct. Active Bystander Intervention is a 90-minute workshop for all members of the campus community: students, faculty, administrators, and staff. This training helps learners acquire the knowledge and skills needed to recognize and intervene in an incident of sexual violence as well as discuss strategies for creating a safer campus community. Uses the 4D’s (Direct, Distract, Delegate, Delay) Active Bystander Intervention Model. (The slide deck that accompanies this resource can be downloaded from the Introduction.)

Long Description:
A workshop and facilitation guide to support B.C. post-secondary institutions to prevent and respond to sexual violence and misconduct. Active Bystander Intervention is a 90-minute workshop for all members of the campus community: students, faculty, administrators, and staff.

This training helps learners acquire the knowledge and skills needed to recognize and intervene in an incident of sexual violence as well as discuss strategies for creating a safer campus community. Uses the 4D’s (Direct, Distract, Delegate, Delay) Active Bystander Intervention Model. (The slide deck that accompanies this resource can be downloaded from the Introduction.)

Word Count: 23063

ISBN: 978-1-77420-106-0

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Subject:
Applied Science
Career and Technical Education
Criminal Justice
Education
Ethnic Studies
Gender and Sexuality Studies
Health, Medicine and Nursing
Law
Psychology
Social Science
Social Work
Sociology
Special Education
Material Type:
Textbook
Provider:
BCcampus
Author:
Sexual Violence Training Development Team
Date Added:
05/03/2021
Active Calculus
Conditional Remix & Share Permitted
CC BY-NC-SA
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Active Calculus is different from most existing calculus texts in at least the following ways: the text is free for download by students and instructors in .pdf format; in the electronic format, graphics are in full color and there are live html links to java applets; the text is open source, and interested instructors can gain access to the original source files upon request; the style of the text requires students to be active learners — there are very few worked examples in the text, with there instead being 3-4 activities per section that engage students in connecting ideas, solving problems, and developing understanding of key calculus concepts; each section begins with motivating questions, a brief introduction, and a preview activity, all of which are designed to be read and completed prior to class; the exercises are few in number and challenging in nature.

Subject:
Calculus
Mathematics
Material Type:
Textbook
Provider:
Grand Valley State University
Author:
David Austin
Matt Boelkins
Steve Schlicker
Date Added:
02/19/2015
Active Calculus 2.0
Conditional Remix & Share Permitted
CC BY-NC-SA
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Active Calculus is different from most existing calculus texts in at least the following ways: the text is freely readable online in HTML format and is also available for in PDF; in the electronic format, graphics are in full color and there are live links to java applets; version 2.0 now contains WeBWorK exercises in each chapter, which are fully interactive in the HTML format and included in print in the PDF; the text is open source, and interested users can gain access to the original source files on GitHub; the style of the text requires students to be active learners — there are very few worked examples in the text, with there instead being 3-4 activities per section that engage students in connecting ideas, solving problems, and developing understanding of key calculus concepts; each section begins with motivating questions, a brief introduction, and a preview activity, all of which are designed to be read and completed prior to class; following the WeBWorK exercises in each section, there are several challenging problems that require students to connect key ideas and write to communicate their understanding.

Subject:
Calculus
Mathematics
Material Type:
Textbook
Provider:
Grand Valley State University
Author:
David Austin
Matt Boelkins
Steve Schlicker
Date Added:
12/01/2020
Active Calculus Multivariable
Conditional Remix & Share Permitted
CC BY-NC-SA
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Active Calculus Multivariable is the continuation of Active Calculus to multivariable functions. The Active Calculus texts are different from most existing calculus texts in at least the following ways: the texts are free for download by students and instructors in .pdf format; in the electronic format, graphics are in full color and there are live html links to java applets; the texts are open source, and interested instructors can gain access to the original source files upon request; the style of the texts requires students to be active learners — there are very few worked examples in the texts, with there instead being 3-4 activities per section that engage students in connecting ideas, solving problems, and developing understanding of key calculus concepts; each section begins with motivating questions, a brief introduction, and a preview activity, all of which are designed to be read and completed prior to class; the exercises are few in number and challenging in nature.

Subject:
Calculus
Mathematics
Material Type:
Textbook
Provider:
Grand Valley State University
Author:
David Austin
Matthew Boelkins
Steven Schlicker
Date Added:
07/01/2018
Active Learning Kit
Unrestricted Use
CC BY
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Engaging Ideas for Live Online Instruction

Short Description:
Active learning ideas for synchronous online class meetings.

Long Description:
Inside, you’ll find many ideas you can use to enliven your synchronous online class meetings with active learning activities. We have organized them into two parts: Web Apps: This part contains teaching ideas for web-based applications you can use with your students for active learning during your class meetings. Videoconference Tool Features: This part contains teaching ideas for using the built-in features of Google Meet, Webex Meetings, and Zoom for active learning during your class meetings.

Word Count: 13869

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Subject:
Education
Educational Technology
Material Type:
Textbook
Provider:
Glendale Community College
Provider Set:
Center for Teaching, Learning, and Engagement
Author:
Cheryl Colan
Date Added:
01/08/2021
Active Learning Worksheets to Pair with Openstax Astronomy
Unrestricted Use
CC BY
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These worksheets were developed by Bryanne McDonough (PhD Candidate, Boston University) for a 6 week summer AS101 course taught at Boston University using the Openstax Astronomy 2e textbook. Each lesson was two hours long, so modification may be necessary for using these worksheets in a shorter class format, although many are already split into two parts. I'm open to feedback and would love to hear if you decide to use this resource in anyway: please contact Bryanne McDonough (bnmcd@bu.edu).

Subject:
Astronomy
Space Science
Material Type:
Activity/Lab
Author:
Bryanne McDonough
Date Added:
08/17/2023
Active Participation: Ensuring Student Engagement
Conditional Remix & Share Permitted
CC BY-SA
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This article describes covert and overt active engagement strategies for use with elementary students. Find the Question templates are included for use with informational text.

Subject:
Applied Science
Computing and Information
Environmental Science
Geoscience
Physical Science
Technology
Material Type:
Lesson Plan
Provider:
Ohio State University College of Education and Human Ecology
Provider Set:
Beyond Penguins and Polar Bears: An Online Magazine for K-5 Teachers
Author:
Clarissa Reeson
Tracey Allen
Date Added:
10/17/2014
Active Participation: Using Math Templates
Read the Fine Print
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Using math templates during instruction keeps each student actively involved and allows the teacher to informally assess each student's proficiency with the skills and concepts addressed in the day's lesson. Many teachers regularly use whiteboards to have students record answers, write terms, draw pictures, etc. The use of templates in sheet protectors extends this practice and eliminates the time spent drawing diagrams, etc., allowing students more time to demonstrate mathematical proficiency. Teachers who regularly use math templates include planned task items that assess student proficiency. Careful observation of student responses allows teachers to form flexible small groups for additional instruction or enrichment and also better plan for instruction.

Material Type:
Teaching/Learning Strategy
Provider:
Mathwire
Author:
Terry Kawas
Date Added:
02/16/2011
Active Prelude to Calculus
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CC BY-SA
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This text is designed for college students who aspire to take calculus and who either need to take a course to prepare them for calculus or want to do some additional self-study. Many of the core topics of the course will be familiar to students who have completed high school. At the same time, we take a perspective on every topic that emphasizes how it is important in calculus.

Subject:
Calculus
Mathematics
Material Type:
Textbook
Author:
Matthew Boelkins
Date Added:
02/18/2022
Active Reading through Self-Assessment: The Student-Made Quiz
Read the Fine Print
Some Rights Reserved
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This recurring lesson encourages students to comprehend their reading through inquiry and collaboration. They choose important quotations from the text and work in groups to formulate "quiz" questions that their peers will answer.

Subject:
English Language Arts
Material Type:
Activity/Lab
Lesson Plan
Provider:
ReadWriteThink
Provider Set:
ReadWriteThink
Date Added:
09/25/2013
Active Recovery/Stretch Series
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CC BY
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This is a quick and easy to implement active recovery/stretch series to use with a PE class that is sore from a few intense workout sessions.  It could be used for a High School Aerobis Class, Lifetime Activities Class or even a Beginning/Advanced Strength Training Class.

Subject:
Education
Material Type:
Activity/Lab
Author:
Michelle Fisher
Date Added:
07/21/2020
Active Tectonics Field Trip
Conditional Remix & Share Permitted
CC BY-NC-SA
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By far most field trips in structural geology and regional tectonics do NOT take place in large urban centers with a trip focus on mitigation of hazards. What is described here is an example of the instructional and learning opportunities associated with active tectonic examination of large population centers.

ACTIVE TECTONICS, HAZARDS, ACTIVE TECTONICS AND SOCIETY, URBAN GEOLOGY, EARTHQUAKES

(Note: this resource was added to OER Commons as part of a batch upload of over 2,200 records. If you notice an issue with the quality of the metadata, please let us know by using the 'report' button and we will flag it for consideration.)

Subject:
Biology
Life Science
Physical Science
Physics
Material Type:
Activity/Lab
Provider:
Science Education Resource Center (SERC) at Carleton College
Provider Set:
Teach the Earth
Author:
George Davis, University of Arizona
Date Added:
09/01/2019
Active Transport - Physiology
Only Sharing Permitted
CC BY-NC-ND
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Active transport is reliant on carrier proteins and thus follows the same rules as facilitated diffusion in that they are specific have a maximum rate and are subject to competition. Crucially they transport substances against their concentration gradient and so require energy to work.

Subject:
Anatomy/Physiology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Anatomy & Physiology
Date Added:
02/05/2015
Active Viewing: 1877: The Grand Army of Starvation
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CC BY-NC-ND
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In this activity, students watch a short clip from the ASHP documentary 1877: The Grand Army of Starvationto learn about the impact of railroad expansion on Americans and the nation as a whole. After watching the clip, students complete the “Technological Turning Points and their Impact” worksheet in order to examine the positive and negative effects of the railroad.

Subject:
History
U.S. History
Material Type:
Activity/Lab
Provider:
City University of New York
Provider Set:
Social History for Every Classroom
Date Added:
11/21/2019
Active Viewing: Abraham and Mary Lincoln: A House Divided
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CC BY-NC-ND
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PBS American Experience’s Abraham and Mary Lincoln: A House Dividedis a 6 episode mini-series available as a 3 DVD set. The following activity focuses on the causes and consequences of Lincoln’s Emancipation Proclamation through an active viewing of Episode 4: The Dearest of All Things(Disc 2). There is a companion website to the series, The Time of the Lincolns, that contains a Teacher’s Guide, primary sources, and episode transcripts.

Subject:
History
U.S. History
Material Type:
Activity/Lab
Provider:
City University of New York
Provider Set:
Social History for Every Classroom
Date Added:
11/21/2019
Active Viewing: Becoming American: The Chinese Experience
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CC BY-NC-ND
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In this activity, students watch short clips of the PBS/A Bill Moyers Special production ofBecoming American: The Chinese Experience(2003). The documentary clips and accompanying materials cover the arrival of Chinese in California, their work on the transcontinental railroad, the passage of the 1882 Chinese Exclusion Act, and the Angel Island immigration facility. At the end of the activity, students complete a short writing task on whether not to immigrate to the United States from the perspective of a young Chinese man.

Subject:
History
U.S. History
Material Type:
Activity/Lab
Provider:
City University of New York
Provider Set:
Social History for Every Classroom
Date Added:
11/21/2019
Active Viewing: Daughters of Free Men
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CC BY-NC-ND
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In this activity, students watch short clips of the ASHP documentary Daughters of Free Mento learn about the experiences of Lowell mill girls in the 1830s. Students follow the life of Lucy, a young girl working in Lowell in 1836. After each clip, students reflect on what they have just learned and predict what Lucy will do next.

Subject:
History
U.S. History
Material Type:
Activity/Lab
Provider:
City University of New York
Provider Set:
Social History for Every Classroom
Date Added:
11/21/2019
Active Viewing: Eyes on the Prize "Awakenings"
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CC BY-NC-ND
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In this activity students analyze the reasons why the Montgomery Bus Boycott lasted so long and was successful. Students watch a short clip from the PBS documentary Eyes on the Prizeabout the Montgomery Bus Boycott. Then students analyze primary sources to determine who participated in the boycott, who organized it, and what challenges boycott supporters faced. The teacher will need access to the filmEyes on the Prize, which is widely available in school and public libraries.

Subject:
History
U.S. History
Material Type:
Activity/Lab
Provider:
City University of New York
Provider Set:
Social History for Every Classroom
Date Added:
11/21/2019