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Are TAM receptors friends or foes in glioblastoma?
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The TAM subfamily of receptor kinases has been implicated in tumor development and progression. Their roles in efferocytosis, regulation of immune cells, secretion of inflammatory factors, and epithelial-to-mesenchymal transition make them key players in tumor development and progression. But TAM signaling is not always beneficial to tumor growth. In glioblastoma (GBM), the most prevalent and lethal primary brain tumor in adults it appears that TAM receptors may also have anti-tumor effects. While upregulation of TAM signaling is usually associated with GBM development, progression, and poor prognosis, TAM receptors may also activate pathways that trigger anti-tumor immune responses and their immunosuppressive role in the tumor microenvironment may obstruct GBM progression..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
02/25/2021
Area and Perimeter of a square (Coordinate Geometry)
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An interactive applet and associated web page showing how to find the area and perimeter of a square from the coordinates of its vertices. The square can be either parallel to the axes or rotated. The grid and coordinates can be turned on and off. The area and perimeter calculation can be turned off to permit class exercises and then turned back on the verify the answers. The applet can be printed as it appears on the screen to make handouts. The web page has a full description of the method for determining area and perimeter, a worked example and has links to other pages relating to coordinate geometry. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

Subject:
Geometry
Mathematics
Material Type:
Reading
Simulation
Provider:
Math Open Reference
Author:
John Page
Date Added:
02/16/2011
Area enclosed by a circle
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An interactive applet and associated web page that demonstrate the area of a circle. A circle is shown with a point on the circumference that can be dragged to resize the circle. As the circle is resized, the radius and the area computation is shown changing in real time. The radius and formula can be hidden for class discussion. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

Subject:
Geometry
Mathematics
Material Type:
Reading
Simulation
Provider:
Math Open Reference
Author:
John Page
Date Added:
02/16/2011
Area enclosed by an ellipse
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An interactive applet and associated web page that demonstrate the area of an ellipse. The major and minor axes can be dragged and the area is continuously recalculated. The ellipse has a grid inside it so that students can estimate the area and compare the result to the calculated one. The web page has the formula for the area calculation. The web page also has links to other pages defining the various properties of an ellipse and to some ellipse constructions. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

Subject:
Geometry
Mathematics
Material Type:
Reading
Simulation
Provider:
Math Open Reference
Author:
John Page
Date Added:
02/16/2011
Area of a Kite
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An interactive applet and associated web page that deals with the area of a kite, (a quadrilateral with two distinct pairs of equal adjacent sides). The applet shows a kite and the user can reshape it by dragging any vertex. The other vertices move automatically to ensure it always remains a kite. As the vertices are dragged, the area is continuously recalculated and displayed. The kite is filled with a grid of unit squares so that the students can estimate the area. The on-screen calculation can be hidden until the estimates are done. The web page lists two different ways to compute the area of a kite. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

Subject:
Geometry
Mathematics
Material Type:
Reading
Simulation
Provider:
Math Open Reference
Author:
John Page
Date Added:
02/16/2011
Area of a parallelogram. Definition and formula
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A web page and interactive applet showing the ways to calculate the area of a parallelogram. The user can drag the vertices of the parallelogram and the other points change automatically to ensure it remains a parallelogram. A grid inside the shape allows students to estimate the area visually, then check against the actual computed area, which is continuously recomputed and displayed. The text on the page gives three different ways to calculate the area with a formula for each. The applet uses one of the methods to compute the area in real time, so it changes as the rhombus is reshaped with the mouse. A companion page is http://www.mathopenref.com/parallelogram.html showing the definition and properties of a parallelogram Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

Subject:
Geometry
Mathematics
Material Type:
Reading
Simulation
Provider:
Math Open Reference
Author:
John Page
Date Added:
02/16/2011
Area of a rectangle. Definition and formula
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A web page and interactive applet showing the ways to calculate the area of a rectangle. The user can drag the vertices of the rectangle and the other points change automatically to ensure it remains a rectangle. A grid inside the shape allows students to estimate the area visually, then check against the actual computed area. The text on the page gives three different ways to calculate the area with a formula for each. The applet uses one of the methods to compute the area in real time, so it changes as the rectangle is reshaped with the mouse. A companion page is http://www.mathopenref.com/rectangle.html showing the definition and properties of a rectangle Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

Subject:
Geometry
Mathematics
Material Type:
Reading
Simulation
Provider:
Math Open Reference
Author:
John Page
Date Added:
02/16/2011
Area of a square. Definition and formula
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An interactive applet and associated web page that demonstrate the area of a square. The applet shows a square with all vertices draggable. As you drag any one, the area id continuously calculated and shown on the applet. The square is filled with a unit grid to allow class estimation of area. The displayed calculation can be turned off. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

Subject:
Geometry
Mathematics
Material Type:
Reading
Simulation
Provider:
Math Open Reference
Author:
John Page
Date Added:
02/16/2011
Area of a trapezoid. Definition and formula
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A web page and interactive applet showing the ways to calculate the area of a trapezoid. The user can drag the vertices of the trapezoid and the other points change automatically to ensure it remains a trapezoid. A grid inside the shape allows students to estimate the area visually, then check against the actual computed area. The text on the page gives three different ways to calculate the area with a formula for each. The applet uses one of the methods to compute the area in real time, so it changes as the trapezoid is reshaped with the mouse. A companion page is http://www.mathopenref.com/trapezoid.html showing the definition and properties of a trapezoid. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

Subject:
Geometry
Mathematics
Material Type:
Reading
Simulation
Provider:
Math Open Reference
Author:
John Page
Date Added:
02/16/2011
Area of a triangle (Coordinate Geometry)
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An interactive applet and associated web page that calculate the area of a triangle using the formula method in coordinate geometry. The applet has a triangle with draggable vertices. As you drag them the triangle's area is recalculated from the vertex coordinates using the formula. The grid and coordinates can be turned on and off. The area calculation can be turned off to permit class exercises and then turned back on the verify the answers. The applet can be printed as it appears on the screen to make handouts. The web page has a full description of the method for determining area using the formula method, a worked example and has links to other pages relating to coordinate geometry. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

Subject:
Geometry
Mathematics
Material Type:
Reading
Simulation
Provider:
Math Open Reference
Author:
John Page
Date Added:
02/16/2011
Area of a triangle (conventional method)
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An interactive applet and associated web page that explain the area of a triangle. The applet shows a triangle that can be reshaped by dragging any vertex. As it changes, the area is continually recalculated using the 'half base times height' method. The triangle has a fixed square grid in its interior that can be used to visually estimate the area for later correlation with the calculated value. The calculation can be hidden while estimation is in progress. The text page has links to a similar page that uses Heron's Formula to compute the area. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

Subject:
Geometry
Mathematics
Material Type:
Reading
Simulation
Provider:
Math Open Reference
Author:
John Page
Date Added:
02/16/2011
Area of a triangle using the box method (Coordinate Geometry)
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An interactive applet and associated web page that calculate the area of a triangle using the box method in coordinate geometry. The applet has a triangle with draggable vertices. As you drag them the triangle's bounding box is shown and the area recalculated by subtracting the areas of the outside triangles. The grid and coordinates can be turned on and off. The area calculation can be turned off to permit class exercises and then turned back on the verify the answers. The applet can be printed as it appears on the screen to make handouts. The web page has a full description of the method for determining area using the box method, a worked example and has links to other pages relating to coordinate geometry. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

Subject:
Geometry
Mathematics
Material Type:
Reading
Simulation
Provider:
Math Open Reference
Author:
John Page
Date Added:
02/16/2011
Are choices based on conditional or conjunctive probabilities in a sequential risk-taking task?
Unrestricted Use
CC BY
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In this study, we examined participants' choice behavior in a sequential risk-taking task. We were especially interested in the extent to which participants focus on the immediate next choice or consider the entire choice sequence. To do so, we inspected whether decisions were either based on conditional probabilities (e.g., being successful on the immediate next trial) or on conjunctive probabilities (of being successful several times in a row). The results of five experiments with a simplified nine-card Columbia Card Task and a CPT-model analysis show that participants' choice behavior can be described best by a mixture of the two probability types. Specifically, for their first choice, the participants relied on conditional probabilities, whereas subsequent choices were based on conjunctive probabilities. This strategy occurred across different start conditions in which more or less cards were already presented face up. Consequently, the proportion of risky choices was substantially higher when participants started from a state with some cards facing up, compared with when they arrived at that state starting from the very beginning. The results, alternative accounts, and implications are discussed.

Subject:
Psychology
Social Science
Material Type:
Reading
Provider:
Journal of Behavioral Decision Making
Author:
Peter Haffke
Ronald Hübner
Date Added:
08/07/2020
Are your ChIP antibodies skewing your data?
Unrestricted Use
CC BY
Rating
0.0 stars

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"It’s a feared moment for every scientist: the discovery that years of painstaking research has led to results that can't be repeated. Many think that poorly characterized antibodies have contributed to this reproducibility crisis more than any other laboratory tool. A new study published in Molecular Cell supports this hypothesis, at least in the context of chromatin immunoprecipitation. Although accurate ChIP interpretation depends on near-perfect antibody specificity, the report shows that many of these reagents are far less capable than their advertising suggests, which calls into question several widely accepted paradigms on genomic regulation. The study focused on histone post-translational modifications; specifically all three methylation states of lysine 4 on histone H3. Through ChIP experiments, H3K4 methylation has been strongly linked to transcriptional control..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Chemistry
Life Science
Physical Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/20/2019
The Argumentative Research Project: A Step-by-Step Course
Conditional Remix & Share Permitted
CC BY-NC-SA
Rating
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This resource is designed to walk students through the process of completing a research project in any field of study. It covers the earliest stages of brainstorming and discussing, continues through researching and compiling sources; writing, documenting, revising, and polishing a paper; and finally presenting the research topic to a wider audience in a professional manner. The focus is on MLA format, though the course could be modified for other formats.

The first unit is an introduction to the project. It asks students to draw on knowledge of issues affecting their own community and world to help generate discussion that could eventually lead to a research topic.

Subject:
Arts and Humanities
Business and Communication
Social Science
Material Type:
Assessment
Full Course
Homework/Assignment
Lecture
Lesson Plan
Reading
Date Added:
07/23/2020