This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Our bodies are home to millions of microscopic organisms – our microbiome. While these microbes have many important functions that maintain our health and well-being, our microbiome changes as we age, which can cause infection or inflammation. Understanding these changes in humans is difficult due to our long lifespan and confounding factors such as healthcare and diet. A recent study used an animal model – free-ranging rhesus macaques – to better understand the changes that occur in our microbiomes with age, using a cross-sectional dataset of oral, rectal, and genital swabs collected from 105 macaques belonging to one social group. In contrast to adult macaques, researchers found that infant gut microbial communities had higher abundances of Bifidobacterium and Bacteroides, consistent with a milk-rich diet. The genital microbiome varied substantially between males and females, and while penile microbiomes changed with age, vaginal microbiomes did not..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Changes in the gut microbiota are associated with numerous ageing-related disorders. Microbiome rejuvenation through probiotic treatment or faecal microbiota transplantation can promote healthy ageing. However, in animal studies, it remains difficult to successfully prolong the health span of aged mice via gut microbiome manipulation. Researchers recently attempted several methods to rejuvenate the microbiomes of aged mice by co-housing young and old mice, injecting old mice with serum from young mice, and surgically combining young and old mice via their circulatory systems. As mice aged, the gut microbiota composition and gene abundance changed dynamically, but the rejuvenation procedures reversed the deterioration of microbe communities and intestinal immunity in aged mice. According to metagenomics, high abundance of Akkermansia (AK) bacteria and the activity of the butyrate synthesis pathway played key roles in the restorative effects..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This collection focuses on a rapidly evolving field in which the study of both species-specific and ubiquitous aging mechanisms informs the biological process of aging. Yet the field is not without substantial controversy, differing views arise as we come to understand aging across model systems - from bacteria to humans.

Open science practices are broadly applicable within the field of aging research. Across study types, these practices carry the potential to influence changes within research practices in aging science that can improve the integrity and reproducibility of studies. Resources on open science practices in aging research can, however, be challenging to discover due to the breadth of aging research and the range of resources available on the subject. By accumulating resources on open science and aging research and compiling them in a centralized location, we hope to facilitate the discoverability and use of these resources among researchers who study aging, and among any other interested parties.  Unfortunately, not all resources are openly available. The following list of resources, while not open access, provide valuable perspectives, information, and insight into the open science movement and its place in aging research. 

Anatomy and Physiology is a dynamic textbook for the two-semester human anatomy and physiology course for life science and allied health majors. The book is organized by body system and covers standard scope and sequence requirements. Its lucid text, strategically constructed art, career features, and links to external learning tools address the critical teaching and learning challenges in the course. The web-based version of Anatomy and Physiology also features links to surgical videos, histology, and interactive diagrams.

This book is written for anyone who could benefit from learning more about health, wellness, and fitness. Throughout the text, readers will learn about health and wellness, setting goals, physical activity and exercise, cardiovascular fitness, muscular strength and endurance, body composition, flexibility, nutrition, stress management, as well as self-care and sleep. In addition to providing important information about the above topics, the text also includes self assessment assignments and self-reflection opportunities. It is the aim of the author that readers increase their understanding regarding the idea that we are all dealt different hands in life, and we all have our history and our own experiences, but one thing we all have in common is that we can start now from wherever we are and make small changes to improve our health, wellness, and fitness.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Critical defects that compromise the nucleus during cell division could be the basis for the age-accelerating effects of people living with progeria. Hutchinson-Gilford progeria syndrome is a genetic disorder that causes premature aging. Affecting one in 8 million newborns worldwide, the disorder is extremely rare—and fatal. The rapid aging of the cardiovascular system causes death due to heart attack or stroke in patients by their mid-teens. Progeria is caused by a tiny point mutation in the lamin A gene. This gene is responsible for producing structural proteins called lamins, which form the scaffolding that holds the cell nucleus together. The mutated form of prelamin A called progerin destabilizes the cell nucleus—the genetic control center of cells. The result is the fast-aging effects observed in progeria. But the link from gene mutation to physical disorder has remained a mystery. Previous studies have looked only at models of progeria, not at actual patient cells..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The skin is the interface between the human body and the environment, and the different features in distinct skin regions, such as different temperatures, humidity levels, gland densities, and pH values, create a variety of niches that can support a diverse skin microbiome. This microbiome includes bacteria, archaea, viruses, fungi, and even mites. A healthy skin microbiome helps maintain skin homeostasis, protects against pathogens, communicates with and trains the immune system, and affects wound healing. However, the skin microbiome can be influenced by many factors, including intrinsic factors like aging and extrinsic factors like cosmetic. Recent advances in molecular biology techniques and next-generation sequencing have drastically increased our understanding of the microorganisms that live on our skin, but the microbes are often still difficult to culture and study..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This course is offered during the Independent Activities Period (IAP), which is a special 4-week term at MIT that runs from the first week of January until the end of the month.
This survey course is intended to review memory and its impact on our lives. Memories make us who we are, and make us what we are going to become. The loss of memory in amnesia can cause us to lose ourselves.
Memory provides a bridge between past and present. Through memory, past sensations, feelings, and ideas that have dropped from conscious awareness can be subsequently recovered to guide current thought and action. In this manner, memory allows us to locate our car in the parking lot at the end of the day or guides us to avoid retelling the same joke to the same friend. This seminar will focus on how memories are created and controlled such that we are able to remember the past. Recent insights from non-human electrophysiological and human brain imaging research will be emphasized.

The objectives of this kit are to improve student perceptions of older adults in terms of creativity, flexibility and competence, and to broaden their understanding of what constitutes "creative" expression. Both documentary and feature films were used in order to explore the differences in intent between these different media, as well as the issues of time period, race, gender, culture and nationality.

Sociology often looks at different age cohorts. A cohort is simply a group of people, but here we're looking specifically at different age groups or generations, because these people all lived through the same certain events through a certain time that affected their lives similarly.

Psychologists must be able to test both for the presence of an effect and for the absence of an effect. In addition to testing against zero, researchers can use the two one-sided tests (TOST) procedure to test for equivalence and reject the presence of a smallest effect size of interest (SESOI). The TOST procedure can be used to determine if an observed effect is surprisingly small, given that a true effect at least as extreme as the SESOI exists. We explain a range of approaches to determine the SESOI in psychological science and provide detailed examples of how equivalence tests should be performed and reported. Equivalence tests are an important extension of the statistical tools psychologists currently use and enable researchers to falsify predictions about the presence, and declare the absence, of meaningful effects.

Credit Hours: 3Lecture Hours: 27Lecture/Lab Hours: 0Lab Hours: 0Course DescriptionProvides an overview of the impact of nutrition on aging and the impact of aging on nutrient needs. Examines food access, procurement, preparation, and enjoyment using a socio-ecological framework of health and wellness. Evaluates age-associated psycho-social, economic, and environmental influences on individual food security and institutional program delivery. Emphasizes nutrition and food for healthy aging. Recommended: FN 110, PSY 236, or SOC 230. Prerequisites: WR 115, RD 115 and MTH 20 or equivalent placement test scores.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new study suggests that transferring gut microbes from aged to young adult mice has measurable effects on parts of the central nervous system, highlighting the importance of the gut–brain axis in aging. Researchers performed fecal transplants from aged or age-matched donors to younger adult mice. The two groups showed significant differences in their microbial profiles. After transplantation, young adult recipients showed no significant changes in markers of anxiety, explorative behavior, or locomotor activity. But recipients did show impaired spatial learning and memory, as measured by a maze test. These changes were paralleled by alterations in the expression of proteins associated with synaptic plasticity and neurotransmission and changes in microglial cells in the hippocampus — the learning and memory center of the brain..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This collection of six images captures the magnificence of human development -- the transformation from baby to woman.

Development of awareness and understanding of the aging process. Health and health-related needs of the aging. Preventive, restorative, and rehabilitative services for the aged.