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Pre-implantation culture conditions may influence stem cells used in arthritis treatment
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Osteoarthritis is a painful degradation of joint cartilage. Therapies that boost cartilage's limited ability to repair using adipose tissue-derived stem cells (ASCs) have shown promise in cell culture and animal studies, but that success has not carried over to clinical trials. This variability in clinical trials may come down to how the cells are cultured prior to implantation. To test this, a recent study examined a co-culture system combining ASCs taken from the fat pad behind the patella and cartilage cells (chondrocytes). Co-cultured ASCs and chondrocytes had higher expression of cartilage-associated genes than expected, and the effect was larger in cultures with a lower ratio of ASCs to chondrocytes. This gene expression change likely reflects changes in the ASCs and would suggest that the ASCs are starting to make the molecular changes needed to repair damaged cartilage, but increased expression in the chondrocytes, rather than the ASCs, cannot be ruled out without further experiments..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/18/2022
Principles of Microeconomics
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CC BY-NC-SA
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Principles of Microeconomics is an adaptation of the textbook, Microeconomics: Markets, Methods, and Models by D. Curtis and I. Irvine, which provides concise yet complete coverage of introductory microeconomic theory, application and policy in a Canadian and global environment.

Subject:
Economics
Social Science
Material Type:
Textbook
Provider:
Lyryx Learning
Author:
Doug Curtis
Ian Irvine
Date Added:
03/31/2017
Research Methods in Psychology
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CC BY-NC-SA
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Research Methods in Psychology is intended to provide a fundamental understanding of the basics of experimental research in the psychological sciences.

Research Methods in Psychology adapted by Michael G. Dudley is licensed under Creative Commons Attribution-NonCommercial-ShareAlike 4.0 license.
Research Methods in Psychology is adapted from a work produced and distributed under a Creative Commons license (CC BY-NC-SA) in 2010 by a publisher who has requested that they and the original author not receive attribution. This adapted edition is based on an adaptation produced by the University of Minnesota Libraries Publishing through the eLearning Support Initiative. This adapted edition was created by Michael G. Dudley with support from the Palomar College Foundation.
This adaptation has significantly altered the original 2010 text and removed images. This work is made available under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike license.

Subject:
Psychology
Social Science
Material Type:
Textbook
Date Added:
01/19/2019
Seminar in Historical Methods
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CC BY-NC-SA
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This course is designed to acquaint students with a variety of approaches to the past used by historians writing in the twentieth century. The books we read have all made significant contributions to their respective sub-fields and have been selected to give as wide a coverage in both field and methodology as possible in one semester’s worth of reading. We examine how historians conceive of their object of study, how they use primary sources as a basis for their accounts, how they structure the narrative and analytic discussion of their topic, and what are the advantages and drawbacks of their various approaches.

Subject:
Arts and Humanities
History
Material Type:
Full Course
Provider Set:
MIT OpenCourseWare
Author:
McCants, Anne
Date Added:
02/01/2004
Social Study of Science and Technology
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CC BY-NC-SA
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This course surveys canonical and recent theories and methods in science studies. We will organize our discussions around the concept of “reproduction,” referring variously to:

Scientific reproduction (how results are replicated in lab, field, disciplinary contexts)
Social reproduction (how social knowledge and relations are regenerated over time)
Biological reproduction (how organic substance is managed in the genetic age)
Electronic reproduction (how information is reassembled in techniques of transcription, simulation, computation).

Examining intersections and disruptions of these genres of reproduction, we seek to map relations among our social, biological, and electronic lives.

Subject:
Arts and Humanities
History
Philosophy
Social Science
Sociology
Material Type:
Full Course
Provider Set:
MIT OpenCourseWare
Author:
Helmreich, Stefan
Date Added:
02/01/2004
Survey of Educational Research Methods syllabus
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Syllabus for Survey of Educational Research Methods course that uses the open textbook Social Science Research: Principles, Methods, and Practices: https://scholarcommons.usf.edu/oa_textbooks/3/

Course description:
This course provides students with a survey of methods used in educational research, including qualitative, survey, quantitative group, correlational, single case, and action research. The role of systematic approaches to research in education is considered, and an overview of multiple ways of conducting research in education is provided. Emphasis will be placed on developing students’ competence in locating, evaluating and using published research to inform decision making in educational, clinical, and social settings. Guidelines for evaluating educational research that use the various methodologies are provided. Students will evaluate and critique published research articles.

Subject:
Education
Material Type:
Syllabus
Author:
Julie Alonzo
Date Added:
03/09/2020
Territorial Conflict
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This graduate seminar introduces an emerging research program within International Relations on territorial conflict. While scholars have recognized that territory has been one of the most frequent issues over which states go to war, territorial conflicts have only recently become the subject of systematic study. This course will examine why territorial conflicts arise in the first place, why some of these conflicts escalate to high levels of violence and why other territorial disputes reach settlement, thereby reducing the likelihood of war. Readings in the course draw upon political geography and history as well as qualitative and quantitative approaches to political science.

Subject:
Arts and Humanities
History
Political Science
Social Science
Material Type:
Full Course
Provider Set:
MIT OpenCourseWare
Author:
Fravel, M.
Date Added:
09/01/2004
Using mechanobiology and materials methods in epithelial-mesenchymal transition research
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Cancer-related mortality, a leading cause of death in the US, is driven by tumor invasion and metastasis. Implicated in these processes is epithelial-to-mesenchymal transition, or EMT. EMT drives invasion through a dramatic reorganization of a cell's cytoskeleton and the extracellular matrix. Because EMT is a rare event, undergone by a few abnormal cells, it is difficult to view directly in a patient. But new research methods are providing a lens into this critical process. Culturing cells on planar surfaces is revealing how their EMT behavior is coordinated and driven by leader cells. Research on the protein vimentin highlights its role in enabling cells to contort during migration or proliferation. Other studies examine how topographically patterning culture surfaces changes the behaviors of cells as they slip into and out of EMT. And 3D matrices are being used to examine the dissemination and disorganization of multicellular clusters..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
03/11/2021
pKa of Fluorescein
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Previously, we showed how different compounds absorb light. The chemical structure of a molecule determines exactly how much light it absorbs, as well as which wavelengths are absorbed. It stands to reason then, that by removing an atom from a molecule, we can change the way it absorbs light. In this experiment, we will relate these two concepts by measuring the absorbance of a molecule under acidic and basic conditions. The changing pH will allow us to find how strongly a specific hydrogen is attached to our molecule, and we will observe how the changing chemical structure affects the observed absorbance. Afterwards, using mathematical analysis, we can experimentally determine the pKa, or affinity of our hydrogen to our parent molecule.

Material Type:
Activity/Lab
Student Guide
Date Added:
02/06/2015